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  • 异山柰素

    Isokaempferide

    异山柰素
    产品编号 CFN93002
    CAS编号 1592-70-7
    分子式 = 分子量 C16H12O6 = 300.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Geranium wilfordii Maxim
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异山柰素 CFN93002 1592-70-7 1mg QQ客服:1148253675
    异山柰素 CFN93002 1592-70-7 5mg QQ客服:1148253675
    异山柰素 CFN93002 1592-70-7 10mg QQ客服:1148253675
    异山柰素 CFN93002 1592-70-7 20mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Imperial College London (United Kingdom)
  • Institute of Chinese Materia Medica (China)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Universidad Veracuzana (Mexico)
  • Shanghai University of TCM (China)
  • Harvard University (USA)
  • Aarhus University (Denmark)
  • Ateneo de Manila University (Philippines)
  • Monash University (Australia)
  • Florida International University (USA)
  • University of Leipzig (Germany)
  • University of Helsinki (Finland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Industrial Food Engineering2015, 19(4):408-413
  • Nat Plants.2016, 3:16205
  • African J. Agricultural Research 2017, 12(13):1164-1168
  • PLoS One.2017, 12(3):e0173585
  • Molecules.2017, 22(2)
  • Food Chem.2017, 228:301-314
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Oncotarget.2017, 8(64):108006-108019
  • Oncotarget.2017, 9(3):4161-4172
  • Int. J. of Food Properties2017, S108-S118
  • J of Engineering Science&Technology2018, 13(9):2820-2828
  • BMC Complement Altern Med.2018, 18(1):221
  • Chem Biol Interact.2018, 290:44-51
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • The Journal of Agromedicine and Medical Sciences2018, 4(1)
  • Front Microbiol.2019, 10:2806
  • Int J Mol Sci.2019, 20(21):E5488
  • Molecules.2019, 24(11):E2102
  • Chem Biol Interact.2019, 298:1-7
  • Academic J of Second Military Medical University2019, 40(1)
  • Appl Biol Chem2019, 62:46
  • TCI CO.2019, US20190151281A1
  • Food Research International2020, 108987
  • ...
  • 生物活性
    Description: Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by reducing neutrophil degranulation, myeloperoxidase activity, mediators as well as TNF-alpha secretion. Isokaempferide is used as a bronchodilator, can induce relaxation of guinea-pig isolated trachea.
    Targets: TNF-α | PGE | Calcium Channel | ATPase | Potassium Channel
    In vitro:
    Biol Pharm Bull. 2000 Apr;23(4):456-60.
    Hepatoprotective effect of Combretum quadrangulare and its constituents.[Pubmed: 10784427]
    The MeOH extract of leaves of Combretum quadrangulare showed significant hepatoprotective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced experimental liver injury in mice and on D-GalN/tumor necrosis factor-alpha (TNF-alpha)-induced cell death in primary cultured mouse hepatocytes.
    METHODS AND RESULTS:
    Phytochemical investigation led to the isolation of thirty cycloartane-type triterpenes together with betulinic acid, beta-sitosterol, beta-sitosterol glucoside, 4 flavones (34-37), and 3 flavone C-glucosides (38-40). These compounds showed various potencies of hepatoprotective effect on D-GalN/TNF-alpha-induced cell death in primary cultured mouse hepatocytes. Quadrangularol B (29), methyl quadrangularate I (33), kamatakenin (34), 5,7,4'-trihydroxy-3,3'-dimethoxyflavone (35), 5,4'-dihydroxy-3,7,3'-trimethoxyflavone (36) and isokaempferide (37) showed strong inhibitory effect on TNF-alpha-induced cell death with IC50 values of 34.3, 33.7, 13.3, 22.4, 13.4 and 22.8 microM, respectively, whereas clinically-used silibinin had an IC50 value of 39.6 microM and glycyrrhizin showed very weak inhibitory effect. Methyl quadrangularates A (30) and N (32), norquadrangularic acid B (31) and vitexin (40) also showed potent inhibition on TNF-alpha-induced cell death with IC50 values of 45.7, 89.3, 67.6 and 40.1 microM, respectively.
    CONCLUSIONS:
    The flavonoids and some of the cycloartane-type triterpenes appeared to be the hepatoprotective principles of the leaves of C. quadrangulare.
    Phytother Res. 2012 Jul;26(7):1023-8.
    Antiproliferative activity of flavonoids: influence of the sequential methoxylation state of the flavonoid structure.[Pubmed: 22184071]
    Dracocephalum kotschyi Boiss. has been used as part of an ethnobotanical remedy against many forms of human cancer in Iran. It has been demonstrated that a flavonoid named xanthomicrol from D. kotschyi contributes to its preferential antiproliferative activity against malignant cells.
    METHODS AND RESULTS:
    In the present study, the antiproliferative activity of its flavonoid fraction was further characterized. Using liquid-liquid extraction and a semi-preparative reversed-phase HPLC method, eight flavonoid aglycones were isolated from the aerial parts of the plant and their identities were confirmed through MS and NMR analyses as luteolin, naringenin, apigenin, isokaempferide, cirsimaritin, penduletin, xanthomicrol and calycopterin. The in vitro antiproliferative activity of each compound was evaluated against a panel of established normal and malignant cell lines using the MTT assay and some structure-activity relationships were observed. The hydroxyflavones (luteolin, apigenin and isokaempferide) exerted comparable antiproliferative activities against malignant and normal cells, while the methoxylated hydroxyflavones (cirsimaritin, penduletin, xanthomicrol and calycopterin) showed preferential activities against tumor cells.
    CONCLUSIONS:
    This activity may be of value in treating tumors as it would exert few side effects in normal tissues. Xanthomicrol selectively inhibited the growth of human gastric adenocarcinoma, while calycopterin selectively prevented human acute promyelocytic leukemia and human colon carcinoma cells proliferation.
    In vivo:
    Basic Clin Pharmacol Toxicol. 2009 Mar;104(3):198-205.
    Effects of amburoside A and isokaempferide, polyphenols from Amburana cearensis, on rodent inflammatory processes and myeloperoxidase activity in human neutrophils.[Pubmed: 19053991]
    The present study evaluated the anti-inflammatory activity of amburoside A (a phenol glucoside) and Isokaempferide (a flavonol) isolated from the trunk bark of Amburana cearensis, a medicinal plant used in northeast Brazil for the treatment of asthma.
    METHODS AND RESULTS:
    Animals (male Wistar rats or Swiss mice) pre-treated with amburoside A (25 and 50 mg/kg) or Isokaempferide (12.5, 25 and 50 mg/kg), orally or intraperitoneally, showed a significant inhibition of the paw oedema induced by carrageenan (1%), prostaglandin E(2) (30 nmol/paw), histamine (200 microg/paw) or serotonin (200 microg/paw). Histological and morphometric evaluations of the rat paw oedema induced by carrageenan showed that amburoside A and Isokaempferide also inhibited the accumulation of inflammatory cells. Amburoside A reduced significantly the paw oedema and the increase in vascular permeability induced by dextran, as related to the control group. Similar results were observed with the Isokaempferide pre-treatment. Furthermore, amburoside A or Isokaempferide inhibited both leucocyte and neutrophil migrations, in mouse peritoneal cavity, after the carrageenan injection. The polyphenols were not cytotoxic and blocked N-formyl-methyl-leucyl-phenylalanine-induced myeloperoxidase release and activity in human neutrophils. In addition, amburoside A and Isokaempferide at 50 and 100 microg/ml concentrations reduced significantly the lipopolysaccharide-mediated increase in tumour necrosis factor-alpha (TNF-alpha) levels.
    CONCLUSIONS:
    These results provide, for the first time, evidence to support the anti-inflammatory activity of amburoside A and Isokaempferide that seems to be related to an inhibition of inflammatory mediators, such as TNF-alpha, as well as histamine, serotonin and prostaglandin E(2), besides leucocyte infiltration in a dose- or concentration-dependent manner. These anti-inflammatory effects can be explained, at least in part, by the ability of these compounds to reduce neutrophil degranulation, myeloperoxidase activity, mediators as well as TNF-alpha secretion.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.33 mL 16.65 mL 33.3 mL 66.6001 mL 83.2501 mL
    5 mM 0.666 mL 3.33 mL 6.66 mL 13.32 mL 16.65 mL
    10 mM 0.333 mL 1.665 mL 3.33 mL 6.66 mL 8.325 mL
    50 mM 0.0666 mL 0.333 mL 0.666 mL 1.332 mL 1.665 mL
    100 mM 0.0333 mL 0.1665 mL 0.333 mL 0.666 mL 0.8325 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Eupalitin; Eupalitin CFN70334 29536-41-2 C17H14O7 = 330.3 5mg QQ客服:215959384
    3,6-二甲氧基芹菜素; 3,6-Dimethoxyapigenin CFN97961 22697-65-0 C17H14O7 = 330.3 5mg QQ客服:215959384
    4',5-二羟基- 3,6,7-三甲氧基黄酮; Penduletin CFN98957 569-80-2 C18H16O7 = 344.3 5mg QQ客服:1148253675
    草质素; Herbacetin CFN99778 527-95-7 C15H10O7 = 302.24 20mg QQ客服:2932563308
    8-甲氧基山奈酚; 8-甲氧基莰非醇; 8-Methoxykaempferol CFN92382 571-74-4 C16H12O7 = 316.3 5mg QQ客服:3257982914
    3,5,7-三羟基-8,4'-二甲氧基黄酮; Prudomestin CFN98453 3443-28-5 C17H14O7 = 330.3 5mg QQ客服:215959384
    5,7-二羟基-3,4',8-三甲氧基黄酮; 5,7-Dihydroxy-3,4',8-trimethoxyflavone CFN99666 1570-09-8 C18H16O7 = 344.3 5mg QQ客服:3257982914
    5,7-二乙酰氧基-3,4',8-三甲氧基黄酮; 5,7-Diacetoxy-3,4',8-trimethoxyflavone CFN98818 5128-43-8 C22H20O9 = 428.4 5mg QQ客服:215959384
    4',5,7-三羟基 3,6,8-三甲氧基黄酮; 4',5,7-Trihydroxy 3,6,8-trimethoxyflavone CFN70413 57393-71-2 C18H16O8 = 360.3 5mg QQ客服:2159513211
    Calycopterin; Calycopterin CFN70374 481-52-7 C19H18O8 = 374.4 5mg QQ客服:2159513211

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