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  • 灵芝酸C1

    Ganoderic acid C1

    灵芝酸C1
    产品编号 CFN92053
    CAS编号 95311-97-0
    分子式 = 分子量 C30H42O7 = 514.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝酸C1 CFN92053 95311-97-0 1mg QQ客服:3257982914
    灵芝酸C1 CFN92053 95311-97-0 5mg QQ客服:3257982914
    灵芝酸C1 CFN92053 95311-97-0 10mg QQ客服:3257982914
    灵芝酸C1 CFN92053 95311-97-0 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Monash University Malaysia (Malaysia)
  • Texas A&M University (USA)
  • Seoul National University of Science and Technology (Korea)
  • University of Hertfordshire (United Kingdom)
  • Florida International University (USA)
  • University of Maryland (USA)
  • University of Indonesia (Indonesia)
  • University of Malaya (Malaysia)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Osmania University (India)
  • Weizmann Institute of Science (Israel)
  • University of the Basque Country (Spain)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Fitoterapia.2015, 100:179-86
  • Nat Plants.2016, 3:16205
  • Tea Res. Ins. Of China2017, 1-12
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • J of L. Chroma.&Related Tech2017, 252-258
  • Front Immunol.2017, 8:1542
  • Oncotarget.2017, 9(3):4161-4172
  • J Sci Food Agric.2017, 97(5):1656-1662
  • J Hematol Oncol.2018, 11(1):112
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • Molecules.2018, 23(2)
  • J Sep Sci.2018, 41(11):2488-2497
  • Oncology Letters2018, 4690-4696
  • Front Cell Infect Microbiol.2018, 8:292
  • Front Microbiol.2019, 10:2806
  • APMIS.2019, 127(10):688-695
  • Food and Agriculture Org. Of the UN2019, 151-160
  • Molecules.2019, 24(16):E3003
  • Phytother Res.2019, 33(3):676-689
  • Environ Toxicol.2019, 34(12):1354-1362
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • Biomolecules.2020, 10(2):E184
  • J Nat Med.2020, 74(1):65-75
  • ...
  • 生物活性
    Description: Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α mediated inflammation in asthma and other inflammatory diseases. Ganoderic acid C1 has anti-tumor-promoting activity. It is moderately active inhibitors against HIV-1 protease.
    Targets: NF-kB | MAPK | AP-1 | TNF-α | IFN-γ | IL Receptor | HIV
    In vitro:
    Inflamm Bowel Dis. 2015 May 19.
    Anti-inflammatory Effects of Ganoderma lucidum Triterpenoid in Human Crohn's Disease Associated with Downregulation of NF-κB Signaling.[Pubmed: 25993687]

    METHODS AND RESULTS:
    Triterpene Ganoderic acid C1 (GAC1) was isolated from G. lucidum. Stimulated RAW 264.7 macrophages were treated with Ganoderic acid C1. Human PBMCs and colonic biopsies were obtained from children with CD and cultured with or without Ganoderic acid C1. TNF-α and other proinflammatory cytokine levels were measured in the culture supernatant. NF-κB signaling was investigated in PBMCs and colonic mucosa treated with Ganoderic acid C1 by In-Cell Western and Western blot analysis. GAC1 decreased TNF-α production by macrophages and PBMCs from CD subjects. Ganoderic acid C1 significantly decreased TNF-α, IFN-γ, and IL-17A production by inflamed colonic biopsies from CD subjects. These effects were due to downregulation of the NF-κB signaling pathway.
    CONCLUSIONS:
    Ganoderic acid C1 inhibited production of TNF-α and other proinflammatory cytokines by PBMCs and inflamed CD colonic mucosa due to blockage of NF-κB activation. Ganoderic acid C1 is a key beneficial constituent in G. lucidum and the Food Allergy Herbal Formula-2 in suppressing the inflammatory cytokines found in CD and warrants clinical investigation for the treatment of CD.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9429 mL 9.7144 mL 19.4288 mL 38.8576 mL 48.572 mL
    5 mM 0.3886 mL 1.9429 mL 3.8858 mL 7.7715 mL 9.7144 mL
    10 mM 0.1943 mL 0.9714 mL 1.9429 mL 3.8858 mL 4.8572 mL
    50 mM 0.0389 mL 0.1943 mL 0.3886 mL 0.7772 mL 0.9714 mL
    100 mM 0.0194 mL 0.0971 mL 0.1943 mL 0.3886 mL 0.4857 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝酸B; Ganoderic acid B CFN92052 81907-61-1 C30H44O7 = 516.7 10mg QQ客服:1148253675
    灵芝烯酸B; Ganoderenic acid B CFN92991 100665-41-6 C30H42O7 = 514.65 5mg QQ客服:1413575084
    灵芝酸C2; Ganoderic acid C2 CFN92054 103773-62-2 C30H46O7 = 518.7 10mg QQ客服:2159513211
    灵芝酸A; Ganoderic acid A CFN92051 81907-62-2 C30H44O7 = 516.7 20mg QQ客服:3257982914
    赤芝酸G甲酯; Methyl lucidente G CFN95058 102607-20-5 C28H42O7 = 490.6 5mg QQ客服:215959384
    灵芝酸C1; Ganoderic acid C1 CFN92053 95311-97-0 C30H42O7 = 514.7 5mg QQ客服:215959384
    灵芝酸LM2; Ganoderic acid LM2 CFN90297 508182-41-0 C30H42O7 = 514.66 5mg QQ客服:1148253675
    灵芝酸D; Ganoderic acid D CFN90292 108340-60-9 C30H42O7 = 514.66 10mg QQ客服:2932563308
    12-羟基灵芝酸D; 12-Hydroxyganoderic acid D CFN91921 942950-96-1 C30H42O8 = 530.65 10mg QQ客服:2159513211
    12β-灵芝酸M; Ganoderic acid M CFN90747 100761-17-9 C30H42O8 = 530.7 5mg QQ客服:2932563308

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