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  • 灵芝酸A

    Ganoderic acid A

    灵芝酸A
    产品编号 CFN92051
    CAS编号 81907-62-2
    分子式 = 分子量 C30H44O7 = 516.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝酸A CFN92051 81907-62-2 10mg QQ客服:215959384
    灵芝酸A CFN92051 81907-62-2 20mg QQ客服:215959384
    灵芝酸A CFN92051 81907-62-2 50mg QQ客服:215959384
    灵芝酸A CFN92051 81907-62-2 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Maryland School of Medicine (USA)
  • Georgia Institute of Technology (USA)
  • Calcutta University (India)
  • University of Madras (India)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Subang Jaya Medical Centre (Malaysia)
  • Chang Gung University (Taiwan)
  • National Research Council of Canada (Canada)
  • Melbourne University (Australia)
  • Biotech R&D Institute (USA)
  • University of Wuerzburg (Germany)
  • Sanford Burnham Medical Research Institute (USA)
  • University of Leipzig (Germany)
  • Semmelweis Unicersity (Hungary)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Journal of Functional Foods2022, 98:105271.
  • Front Plant Sci.2021, 12:673337.
  • J Mater Chem B.2019, 7(39):5896-5919
  • The Catharanthus Genome2022,35-83.
  • Korean J of Food Science&Technology 2017, 49(2):146-150
  • J Sep Sci.2022, 45(18):3556-3566.
  • Molecules.2019, 24(16):E3003
  • J Biochem Mol Toxicol.2022, e23211.
  • Pharmaceutics2022, 14(2),376.
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • Clin Exp Pharmacol Physiol.2020, doi: 10.1111
  • Advances in Traditional Medicine2020, 10.1007
  • Int J Mol Sci.2015, 16(1):1232-51
  • Life Sci.2022, 311(Pt A):121157.
  • Chemistry of plant raw materials2021, 1:pp 139-150
  • Neuropharmacology.2018, 131:68-82
  • Chem Biol Interact.2019, 315:108910
  • Eur J Pharmacol.2022, 917:174744.
  • Heliyon2020, 6(6):e04337.
  • J Food Compos Anal2017, 62:197-204
  • Molecules.2018, 23(3):E615
  • Nutrients.2019, 12(1)
  • JMicrobiol Biotech Food Sci2021, e4289.
  • ...
  • 生物活性
    Description: Ganoderic acid A , a representative active triterpenoid from Ganoderma lucidum, exhibits antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities. It has a wide spectrum of targets including nuclear transcription factor-kappaB,activator protein-1,STAT,IL-6,JAK, and p38MAPK.
    Targets: NF-kB | AP-1 | STAT | JAK | p38MAPK | IL Receptor
    In vitro:
    Nan Fang Yi Ke Da Xue Xue Bao. 2015 May 20;35(5):619-24.
    Ganoderic acid A suppresses proliferation and invasion and induces apoptosis in human osteosarcoma cells.[Pubmed: 26018252]
    To investigate the effect of ganoderic acid A (GA-A) on the biological behaviors of human osteosarcoma cells in vitro.
    METHODS AND RESULTS:
    MG63 and HOS cells were treated with 0.1, 0.25, and 0.5 mmol/L GA-A, and the changes in cell proliferation, apoptosis and migration were evaluated using MTT assay, flow cytometry, and Transwell assay, respectively. The expressions of STAT3, p38, and NF-κB1 in the cells were analyzed by Western blotting. GA-A effectively inhibited the proliferation of human osteosarcoma HOS and MG-63 cells in a dose-dependent manner, and induced obvious cell apoptosis in both cells. Treatment with 0.5 mmol/L GA-A also resulted in significant inhibition of the invasion of both cells. The results of Western blotting showed that GA-A down-regulated the expression level of phosphorylated STAT3 and increased the phosphorylation level of p38 and NF-κB1 expression in both cells.
    CONCLUSIONS:
    GA-A can induce proliferation inhibition, apoptosis and suppression of invasion in human osteosarcoma HOS and MG-63 cells.
    Int J Med Mushrooms. 2013;15(2):175-82.
    Production of Ginkgo leaf-shaped basidiocarps of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes), containing high levels of α- and β-D-glucan and ganoderic acid A.[Pubmed: 23557369 ]

    METHODS AND RESULTS:
    Ganoderic acid A and α- and β-D-glucan content were compared among morphologically different basidiocarps of the medicinal mushroom Ganoderma lucidum. Ginkgo leaf-shaped basidiocarps gradually hardened from the base to the pileus and accumulated a higher amount of bioactive components than normal (kidney-shaped) and antler/deer horn-shaped basidiocarps. In the normal G. lucidum stipe, the outer context contained the highest amount of α- and β-D-glucan (approximately 55%) and the highest amount of ganoderic acid A (approximately 0.3%).
    CONCLUSIONS:
    Ginkgo leaf-shaped G. lucidum had a large area of outer layer and stout outer context, which contributed to their high α- and β-D-glucan and ganoderic acid A content.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9354 mL 9.6768 mL 19.3536 mL 38.7072 mL 48.384 mL
    5 mM 0.3871 mL 1.9354 mL 3.8707 mL 7.7414 mL 9.6768 mL
    10 mM 0.1935 mL 0.9677 mL 1.9354 mL 3.8707 mL 4.8384 mL
    50 mM 0.0387 mL 0.1935 mL 0.3871 mL 0.7741 mL 0.9677 mL
    100 mM 0.0194 mL 0.0968 mL 0.1935 mL 0.3871 mL 0.4838 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝酸LM2; Ganoderic acid LM2 CFN90297 508182-41-0 C30H42O7 = 514.66 10mg QQ客服:1457312923
    灵芝烯酸G; Ganoderenic acid G CFN95517 120481-73-4 C30H40O7 = 512.6 5mg QQ客服:2056216494
    灵芝酸 J; Ganoderic acid J CFN95516 100440-26-4 C30H42O7 = 514.7 10mg QQ客服:1413575084
    灵芝酸D; Ganoderic acid D CFN90292 108340-60-9 C30H42O7 = 514.66 20mg QQ客服:215959384
    灵芝酸D甲酯; Methyl ganoderate D CFN95581 97210-12-3 C31H44O7 = 528.7 5mg QQ客服:3257982914
    12-羟基灵芝酸D; 12-Hydroxyganoderic acid D CFN91921 942950-96-1 C30H42O8 = 530.65 5mg QQ客服:1457312923
    12-乙酰氧基灵芝酸D; 12-Acetoxy ganoderic acid D CFN95535 N/A C32H44O9 = 572.7 5mg QQ客服:1457312923
    12β-灵芝酸M; Ganoderic acid M CFN90747 100761-17-9 C30H42O8 = 530.7 10mg QQ客服:215959384
    灵芝酸Z; Ganoderic acid Z CFN90295 294674-09-2 C30H42O7 = 514.66 5mg QQ客服:215959384
    灵芝酸AM1; Ganoderic acid AM1 CFN90296 149507-55-1 C30H42O7 = 514.66 5mg QQ客服:1413575084

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