灵芝酸B

Ganoderic acid B

	产品编号	CFN92052
	CAS编号	81907-61-1
	分子式 = 分子量	C₃₀H₄₄O₇ = 516.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The fruit body of Ganoderma lucidum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
灵芝酸B	CFN92052	81907-61-1	10mg	QQ客服：3257982914
灵芝酸B	CFN92052	81907-61-1	20mg	QQ客服：3257982914
灵芝酸B	CFN92052	81907-61-1	50mg	QQ客服：3257982914
灵芝酸B	CFN92052	81907-61-1	100mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Ganoderic acid B is a chemical marker in quality control of G. lucidum and related products. Ganoderic acid B-containing herbs has potential influence towards therapeutic window of trifluoperazine.Ganoderic acid B has antinociceptive effect; it is moderately active inhibitors against HIV-1 protease with a 50% inhibitory concentration of 0.17-0.23 mM.

Targets:

In vitro:

Int J Med Mushrooms . 2018;20(9):859-871.

Triterpenes and Soluble Polysaccharide Changes in Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), During Fruiting Growth[Pubmed: 30317980]

Abstract We analyzed the changes in triterpenes and soluble polysaccharides in Ganoderma lucidum strain G0119 during 4 growth phases in 3 regions of the fruiting bodies using reversed-phase high-performance liquid chromatography, and we also analyzed the soluble polysaccharides using high-performance size-exclusion chroma-tography-multiple-angle laser-light scattering refractive index analysis. The strong polar triterpenes decreased while weak polar triterpenes increased during the growth cycle of G. lucidum. The highest contents of ganoderic acid B, ganoderic acid A, and ganoderenic acid B were detected in the stipe during phase II, and ganoderic acid S, ganoderic acid T, and ganoderiol B peaked in the base during phase IV. The total content of soluble polysaccharides in samples decreased after the primordium developed into a fruiting body. Two high-molecular-weight fractions were detected in the soluble polysaccharide samples: α-l,4-glucan and β-l,3-glucan, respectively. They were primarily distributed in the pileus during phase II, and both decreased after this phase. These results led us to select a more suitable growth phase and region for harvesting to obtain extracts with higher contents of triterpenes and soluble polysaccharides.

In vivo:

Biomed Chromatogr. 2013 Sep;27(9):1177-87.

Structural identification of the metabolites of ganoderic acid B from Ganoderma lucidum in rats based on liquid chromatography coupled with electrospray ionization hybrid ion trap and time-of-flight mass spectrometry.[Pubmed: 23723086]

Ganoderic acid B (GAB), a representative triterpenoid in Ganoderma lucidum, possesses various pharmaceutical effects and has been used as a chemical marker in quality control of G. lucidum and related products.
METHODS AND RESULTS:
The metabolites of GAB in vivo after its oral administration to rats were investigated by liquid chromatography coupled with electrospray ionization hybrid ion trap and time-of-flight mass spectrometry. A total of 14 metabolites of GAB in rat plasma, bile and various organs were detected and identified by direct comparison with the authentic compounds and their characteristic mass fragmentation patterns. The results showed that oxidization and hydroxylation were the common metabolic pathways for GAB in rats. Moreover, some reduction metabolites of GAB were detected in rat kidney and stomach and glucuronidation only appeared in rat bile.
CONCLUSIONS:
This is the first report on the metabolites of GAB in vivo.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
灵芝酸C2; Ganoderic acid C2	CFN92054	103773-62-2	C₃₀H₄₆O₇ = 518.7	20mg	QQ客服：2056216494
灵芝酸A; Ganoderic acid A	CFN92051	81907-62-2	C₃₀H₄₄O₇ = 516.7	20mg	QQ客服：3257982914
灵芝酸A甲酯; Methyl ganoderate A	CFN95550	105742-78-7	C₃₁H₄₆O₇ = 530.7	5mg	QQ客服：1413575084
赤芝酸G甲酯; Methyl lucidenate G	CFN95058	102607-20-5	C₂₈H₄₂O₇ = 490.6	5mg	QQ客服：3257982914
灵芝酸C1; Ganoderic acid C1	CFN92053	95311-97-0	C₃₀H₄₂O₇ = 514.7	5mg	QQ客服：2159513211
灵芝酸LM2; Ganoderic acid LM2	CFN90297	508182-41-0	C₃₀H₄₂O₇ = 514.66	10mg	QQ客服：2056216494
灵芝烯酸G; Ganoderenic acid G	CFN95517	120481-73-4	C₃₀H₄₀O₇ = 512.6	5mg	QQ客服：1457312923
灵芝酸 J; Ganoderic acid J	CFN95516	100440-26-4	C₃₀H₄₂O₇ = 514.7	10mg	QQ客服：2056216494
灵芝酸D; Ganoderic acid D	CFN90292	108340-60-9	C₃₀H₄₂O₇ = 514.66	20mg	QQ客服：1457312923
灵芝酸D甲酯; Methyl ganoderate D	CFN95581	97210-12-3	C₃₁H₄₄O₇ = 528.7	5mg	QQ客服：215959384

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9354 mL	9.6768 mL	19.3536 mL	38.7072 mL	48.384 mL
5 mM	0.3871 mL	1.9354 mL	3.8707 mL	7.7414 mL	9.6768 mL
10 mM	0.1935 mL	0.9677 mL	1.9354 mL	3.8707 mL	4.8384 mL
50 mM	0.0387 mL	0.1935 mL	0.3871 mL	0.7741 mL	0.9677 mL
100 mM	0.0194 mL	0.0968 mL	0.1935 mL	0.3871 mL	0.4838 mL

灵芝酸B

Ganoderic acid B

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