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  • 灵芝酸B

    Ganoderic acid B

    灵芝酸B
    产品编号 CFN92052
    CAS编号 81907-61-1
    分子式 = 分子量 C30H44O7 = 516.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝酸B CFN92052 81907-61-1 1mg QQ客服:2932563308
    灵芝酸B CFN92052 81907-61-1 5mg QQ客服:2932563308
    灵芝酸B CFN92052 81907-61-1 10mg QQ客服:2932563308
    灵芝酸B CFN92052 81907-61-1 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Rio de Janeiro State University (Brazil)
  • University of Sao Paulo (Brazil)
  • Ateneo de Manila University (Philippines)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Kamphaengphet Rajabhat University (Thailand)
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  • University of Parma (Italy)
  • Donald Danforth Plant Science Center (USA)
  • Sri Ramachandra University (India)
  • Colorado State University (USA)
  • University of Bonn (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Scientific World Journal.2014, 2014:654193
  • J Breast Cancer.2015, 18(2):112-118
  • Inflammation.2015, 38(4):1502-16
  • Br J Pharmacol.2016, 173(2):396-410
  • Chemistr of plant2016, 2016021195
  • Mol Pharm.2017, 14(9):3164-3177
  • J Ethnopharmacol.2017, 206:327-336
  • Cell Physiol Biochem.2017, 44(4):1381-1395
  • LWT-Food Science and Technology2017, 75:488-496
  • PLoS One.2018, 13(4):e0195642
  • Sci Rep.2018, 8:15059
  • J Nat Prod.2018, 81(4):966-975
  • Journal of Life Science2018, 917-922
  • Front Microbiol.2019, 10:2806
  • Chemistry of Plant Materials.2019, 129-136
  • J Pharm Biomed Anal.2019, 172:268-277
  • J Ethnopharmacol.2019, 236:31-41
  • Chinese Pharmacological Bulletin2019, 35(8):1120-1125
  • Phytomedicine.2019, 59:152785
  • Appl Biol Chem2019, 62:46
  • Planta Med.2019, 85(3):217-224
  • Br J Pharmacol.2020, 10.1111
  • Appl Biochem Biotechnol.2020, 190(2):732-744
  • ...
  • 生物活性
    Description: Ganoderic acid B is a chemical marker in quality control of G. lucidum and related products. Ganoderic acid B-containing herbs has potential influence towards therapeutic window of trifluoperazine.Ganoderic acid B has antinociceptive effect; it is moderately active inhibitors against HIV-1 protease with a 50% inhibitory concentration of 0.17-0.23 mM.
    Targets: JAK | STAT | IL Receptor | p38MAPK | NF-kB | HIV-1
    In vivo:
    Biomed Chromatogr. 2013 Sep;27(9):1177-87.
    Structural identification of the metabolites of ganoderic acid B from Ganoderma lucidum in rats based on liquid chromatography coupled with electrospray ionization hybrid ion trap and time-of-flight mass spectrometry.[Pubmed: 23723086]
    Ganoderic acid B (GAB), a representative triterpenoid in Ganoderma lucidum, possesses various pharmaceutical effects and has been used as a chemical marker in quality control of G. lucidum and related products.
    METHODS AND RESULTS:
    The metabolites of GAB in vivo after its oral administration to rats were investigated by liquid chromatography coupled with electrospray ionization hybrid ion trap and time-of-flight mass spectrometry. A total of 14 metabolites of GAB in rat plasma, bile and various organs were detected and identified by direct comparison with the authentic compounds and their characteristic mass fragmentation patterns. The results showed that oxidization and hydroxylation were the common metabolic pathways for GAB in rats. Moreover, some reduction metabolites of GAB were detected in rat kidney and stomach and glucuronidation only appeared in rat bile.
    CONCLUSIONS:
    This is the first report on the metabolites of GAB in vivo.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9354 mL 9.6768 mL 19.3536 mL 38.7072 mL 48.384 mL
    5 mM 0.3871 mL 1.9354 mL 3.8707 mL 7.7414 mL 9.6768 mL
    10 mM 0.1935 mL 0.9677 mL 1.9354 mL 3.8707 mL 4.8384 mL
    50 mM 0.0387 mL 0.1935 mL 0.3871 mL 0.7741 mL 0.9677 mL
    100 mM 0.0194 mL 0.0968 mL 0.1935 mL 0.3871 mL 0.4838 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝烯酸B; Ganoderenic acid B CFN92991 100665-41-6 C30H42O7 = 514.65 5mg QQ客服:2932563308
    灵芝酸C2; Ganoderic acid C2 CFN92054 103773-62-2 C30H46O7 = 518.7 10mg QQ客服:2159513211
    灵芝酸A; Ganoderic acid A CFN92051 81907-62-2 C30H44O7 = 516.7 20mg QQ客服:2159513211
    赤芝酸G甲酯; Methyl lucidente G CFN95058 102607-20-5 C28H42O7 = 490.6 5mg QQ客服:215959384
    灵芝酸C1; Ganoderic acid C1 CFN92053 95311-97-0 C30H42O7 = 514.7 5mg QQ客服:215959384
    灵芝酸LM2; Ganoderic acid LM2 CFN90297 508182-41-0 C30H42O7 = 514.66 5mg QQ客服:2932563308
    灵芝酸D; Ganoderic acid D CFN90292 108340-60-9 C30H42O7 = 514.66 10mg QQ客服:2932563308
    12-羟基灵芝酸D; 12-Hydroxyganoderic acid D CFN91921 942950-96-1 C30H42O8 = 530.65 10mg QQ客服:2159513211
    12β-灵芝酸M; Ganoderic acid M CFN90747 100761-17-9 C30H42O8 = 530.7 5mg QQ客服:2932563308
    灵芝酸Z; Ganoderic acid Z CFN90295 294674-09-2 C30H42O7 = 514.66 5mg QQ客服:2932563308

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