• 中药标准品生产商,产品定制服务
  • 松果菊苷

    Echinacoside

    松果菊苷
    产品编号 CFN98105
    CAS编号 82854-37-3
    分子式 = 分子量 C35H46O20 = 786.72
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The rhizomes of Cistanche tubulosa (Schenk) Wight
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    松果菊苷 CFN98105 82854-37-3 10mg QQ客服:2159513211
    松果菊苷 CFN98105 82854-37-3 20mg QQ客服:2159513211
    松果菊苷 CFN98105 82854-37-3 50mg QQ客服:2159513211
    松果菊苷 CFN98105 82854-37-3 100mg QQ客服:2159513211
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Uniwersytet Gdański (Poland)
  • University of Minnesota (USA)
  • Aveiro University (Portugal)
  • Texas A&M University (USA)
  • Amity University (India)
  • University of Cincinnati (USA)
  • Semmelweis Unicersity (Hungary)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Northeast Normal University Changchun (China)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Kitasato University (Japan)
  • Universidad de La Salle (Mexico)
  • Anna University (India)
  • Universidade Católica Portuguesa (Portugal)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytochem Anal.2013, 24(5):493-503
  • Sci. Rep.2015, 14-23
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • J Ethnopharmacol.2017, 209:305-316
  • Food Chem.2017, 228:301-314
  • Korean J of Food Science&Technology 2017, 49(2):146-150
  • Korean j.of Pharm.2017, 70-76
  • J Nat Med.2017, 71(2):380-388
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Journal of Ginseng Research2019, 10.1016
  • Analytical methods2019, 11(6)
  • ACS Chem Biol.2019, 14(5):873-881
  • Int J Mol Sci.2019, 20(16):E4015
  • Spectrochim Acta A2019, 210:372-380
  • Molecules.2019, 24(1):E159
  • Food and Fermentation Industries2019, 45(7):45-51
  • Metabolites.2019, 9(11):E271
  • Oxid Med Cell Longev2019, 9056845:13
  • Appl. Sci.2020, 10,1304
  • Front Plant Sci.2020, 10:1705
  • Plant Cell Tiss Org2020, 1-16
  • United States Patent Application2020, 20200038363
  • Antioxidants (Basel).2020, 9(2):E120
  • ...
  • 生物活性
    Description: Echinacoside is a natural polyphenolic compound, has various kinds of pharmacological activities, such as anti-senescence, anti-hypoxia, anti-cancer, anti-osteoporosis, antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative ones. Echinacoside can improve the hematopoietic function of bone marrow in 5-FU-induced myelosuppression mice, it induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1. Echinacoside inhibits cytochrome c release and caspase-3 activation caused by ensuing rotenone exposure via activating Trk-extracellular signal-regulated kinase (ERK) pathway in neuronal cells.
    Targets: ROS | PI3K | Trk receptor | Caspase | ERK | Beta Amyloid | HIF | Bcl-2/Bax | CDK | p21
    In vitro:
    Int J Biol Macromol. 2015 Jan;72:243-53.
    Echinacoside inhibits amyloid fibrillization of HEWL and protects against Aβ-induced neurotoxicity.[Pubmed: 25193102]
    We investigated the protection provided by echinacoside against neurotoxicity induced by β-amyloid protein (Aβ). Through spectroscopic analyses, electron microscopy, cell viability assay, and hemolysis assay, we found that echinacoside dose dependently inhibited HEWL aggregation, and this inhibition occurred in different fiber-forming stages. echinacoside could also scavenge the DPPH and OH free radicals in a concentration-dependent manner. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and 2',7'-dichlorodihydrofluoresceindiacetate (DCFH-DA) fluorescent measurement results indicated that echinacoside could increase viability of rat pheochromocytoma PC12 cells injured by Aβ and suppress the increase in intracellular reactive oxygen species (ROS) triggered by Aβ. The present study findings facilitate a better understanding of the interaction between echinacoside and amyloid-forming proteins and also shed light on the protection of echinacoside against amyloid fibril-induced neuronal cell death.
    J Pharmacol Sci. 2014;126(2):155-63.
    Antiproliferative effect of echinacoside on rat pulmonary artery smooth muscle cells under hypoxia.[Pubmed: 25341567]
    The main purpose of this study is to evaluate the effect of echinacoside (ECH) on hypoxia-induced proliferation of rat pulmonary artery smooth muscle cells (PASMCs) and the underlying mechanism.
    METHODS AND RESULTS:
    PASMCs were incubated under normoxia (nor), hypoxia (hyp), hypoxia + 0.35 mM ECH (hyp + ECH0.35), or hypoxia + 0.4 mM ECH (hyp + ECH0.4) for 24 h. Cell viability was assessed by MTS assays. The morphology of apoptosis was observed by DAPI staining, and apoptosis was quantified by flow cytometric analysis. Caspase-3 activity was determined by immunohistochemistry and real-time PCR, and the expressions of HIF-1α, Bax, Bcl-2, and Fas were determined by real-time PCR. Hypoxia induced significant proliferation of PASMCs, which could be inhibited by ECH in a concentration-dependent manner. This was associated with apoptosis of PASMCs. Z-DEVD-FMK could partly reduce the suppression effect of ECH; protein and gene expression of caspase-3 were significantly higher in the hyp + ECH0.4 and hyp + ECH0.35 groups. ECH significantly increased the expressions of Bax and Fas, but decreased the expressions of Bcl-2 and HIF-1α.
    CONCLUSIONS:
    ECH could inhibit hypoxia-induced proliferation of rat PASMCs, which is associated with apoptosis of PASMCs and improvement of hypoxia. ECH might be a potential agent for prevention and treatment of hypoxia-induced PAH.
    Onco Targets Ther. 2015 Dec 8;8:3649-64.
    Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1.[Pubmed: 26677335 ]
    Inhibition of the nucleotide pool sanitizing enzyme MTH1 causes extensive oxidative DNA damages and apoptosis in cancer cells and hence may be used as an anticancer strategy. As natural products have been a rich source of medicinal chemicals, in the present study, we used the MTH1-catalyzed enzymatic reaction as a high-throughput in vitro screening assay to search for natural compounds capable of inhibiting MTH1.
    METHODS AND RESULTS:
    Echinacoside, a compound derived from the medicinal plants Cistanche and Echinacea, effectively inhibited the catalytic activity of MTH1 in an in vitro assay. Treatment of various human cancer cell lines with Echinacoside resulted in a significant increase in the cellular level of oxidized guanine (8-oxoguanine), while cellular reactive oxygen species level remained unchanged, indicating that Echinacoside also inhibited the activity of cellular MTH1. Consequently, Echinacoside treatment induced an immediate and dramatic increase in DNA damage markers and upregulation of the G1/S-CDK inhibitor p21, which were followed by marked apoptotic cell death and cell cycle arrest in cancer but not in noncancer cells.
    CONCLUSIONS:
    Taken together, these studies identified a natural compound as an MTH1 inhibitor and suggest that natural products can be an important source of anticancer agents.
    In vivo:
    Scand J Gastroenterol. 2014 Aug;49(8):993-1000.
    Echinacoside ameliorates D-galactosamine plus lipopolysaccharide-induced acute liver injury in mice via inhibition of apoptosis and inflammation.[Pubmed: 24797709]
    This study aimed to investigate the protective effects of Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche salsa, a Chinese herbal medicine, on D-galactosamine (GalN) and lipopolysaccharide (LPS)-induced acute liver injury in mice.
    METHODS AND RESULTS:
    Pretreatment with Echinacoside remarkably improved the survival rate of GalN/LPS-treated mice and attenuated acute hepatotoxicity, as demonstrated by decreased ALT levels and improved histological signs. Echinacoside shows both anti-apoptotic and anti-inflammatory properties, characterized by a substantial inhibition of hepatocyte apoptosis and a significant reduction in the inflammatory markers, including myeloperoxidase, extracellular nucleosomes, high-mobility group box 1, and inflammatory cytokines in the plasma of mice, which may be important mechanisms related to its protective effect.
    CONCLUSIONS:
    Our results suggest that Echinacoside can provide a pronounced protection against GalN/LPS-induced acute liver injury in mice, which may complement the available strategies for management of acute liver damage in clinical settings.
    Life Sci. 2015 Feb 15;123:86-92.
    Echinacoside improves hematopoietic function in 5-FU-induced myelosuppression mice.[Pubmed: 25623854]
    We aimed to investigate the effects of echinacoside (ECH) on hematopoietic function in 5-FU-induced bone marrow depression mice.
    METHODS AND RESULTS:
    In vitro, after stimulation with ECH, the proliferation ability of bone marrow (BM) cells and bone marrow stromal cells (BMSCs) derived from myelosuppression mice were assessed by CCK8 assay and morphology, respectively. In vivo, 5-FU-induced myelosuppression or control mice were intragastrically administrated with either ECH at 15 mg/kg or the equal volume of normal saline daily for 12 days before BM cells were isolated for colony-forming cell assay. Meanwhile, BMSCs were cultured for 4 weeks before cells were observed for growth pattern, cell culture supernatants were collected for GM-CSF secretion by ELISA, and RNA of the cells were extracted for EPO and GM-CSF RT-PCR. BM cells or BMSCs stimulated with ECH for 24 h or 48 h were collected for protein extraction and Western blotting. ECH stimulated the growth of BM cells but not BMSCs derived from 5-FU treated mice. The intragastric administration of ECH in 5-FU treated mice could increase the number of total hematopoietic progenitor cells and GM progenitor cells to healthy control mice level, but not BFU progenitor cells. BMSCs from ECH treated myelosuppression mice grew more vigorously and expressed more GM-CSF, but not EPO. ECH activated the PI3K signaling pathway in 5-FU suppressed BM cells.
    CONCLUSIONS:
    ECH could improve the hematopoietic function of bone marrow in 5-FU-induced myelosuppression mice. ECH can be considered as an alternative effective therapy for patients during chemotherapy or HSC transplantation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2711 mL 6.3555 mL 12.711 mL 25.422 mL 31.7775 mL
    5 mM 0.2542 mL 1.2711 mL 2.5422 mL 5.0844 mL 6.3555 mL
    10 mM 0.1271 mL 0.6356 mL 1.2711 mL 2.5422 mL 3.1778 mL
    50 mM 0.0254 mL 0.1271 mL 0.2542 mL 0.5084 mL 0.6356 mL
    100 mM 0.0127 mL 0.0636 mL 0.1271 mL 0.2542 mL 0.3178 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Teupolioside; Teupolioside CFN70272 143617-02-1 C35H46O20 = 786.7 5mg QQ客服:3257982914
    6-O-(E)-咖啡酰基葡萄糖苷; 6-O-(E)-Caffeoylglucopyranose CFN95105 209797-79-5 C15H18O9 = 342.3 5mg QQ客服:2159513211
    6-O-阿魏酰葡萄糖; 6-O-Feruloylglucose CFN99431 137887-25-3 C16H20O9 = 356.3 5mg QQ客服:1148253675
    6'-O-阿魏酰蔗糖; Arillatose B CFN99432 137941-45-8 C22H30O14 = 518.5 5mg QQ客服:2932563308
    西伯利亚远志糖A5; Sibiricose A5 CFN90645 107912-97-0 C22H30O14 = 518.5 20mg QQ客服:2159513211
    西伯利亚远志糖A6; Sibiricose A6 CFN90646 241125-75-7 C23H32O15 = 548.5 20mg QQ客服:1148253675
    6-O-咖啡酰基熊果甙; 6-O-Caffeoylarbutin CFN99427 136172-60-6 C21H22O10 = 434.4 5mg QQ客服:1148253675
    灯盏花苷 I; Erigeside I CFN96865 224824-74-2 C20H20O11 = 436.36 5mg QQ客服:1148253675
    木通苯乙醇苷B; Calceolarioside B CFN90647 105471-98-5 C23H26O11 = 478.45 20mg QQ客服:1148253675
    木通苯乙醇苷A; Calceolarioside A CFN98522 84744-28-5 C23H26O11 = 478.44 5mg QQ客服:215959384

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产