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  • 连翘酯苷B

    Forsythoside B

    连翘酯苷B
    产品编号 CFN99715
    CAS编号 81525-13-5
    分子式 = 分子量 C34H44O19 = 756.70
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The fruits of Forsythia suspensa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    连翘酯苷B CFN99715 81525-13-5 10mg QQ客服:215959384
    连翘酯苷B CFN99715 81525-13-5 20mg QQ客服:215959384
    连翘酯苷B CFN99715 81525-13-5 50mg QQ客服:215959384
    连翘酯苷B CFN99715 81525-13-5 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • University Medical Center Mainz (Germany)
  • Nanjing University of Chinese Medicine (China)
  • Ain Shams University (Egypt)
  • The University of Newcastle (Australia)
  • Subang Jaya Medical Centre (Malaysia)
  • University of Eastern Finland (Finland)
  • Seoul National University of Science and Technology (Korea)
  • Kyushu University (Japan)
  • Cornell University (USA)
  • Florida International University (USA)
  • University of Virginia (USA)
  • University of East Anglia (United Kingdom)
  • Massachusetts General Hospital (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules. 2013, 18(7):7376-88
  • Phytomedicine.2015, 22(14):1262-8
  • Universidade Estadual Paulista2017, 11449
  • Acta horticulturae2017, 1158:257-268
  • Molecules.2017, 22(2)
  • Molecules.2018, 23(10):E2638
  • Nat Prod Sci.2018, 24(2):109-114
  • Food and Fermentation Industries2018, 44(371)
  • BMB Rep.2018, 51(5):249-254
  • Biomol Ther (Seoul).2019, 10.4062
  • Pharmacognosy Journal2019, 11(2): 369-373
  • Nutr Res Pract2019, 13:e45
  • Life Sci.2019, 216:259-270
  • J Ethnopharmacol.2019, 241:112025
  • FASEB J.2019, 33(8):9685-9694
  • Pharmaceutical Chemistry Journal2019, 52(12):986-991
  • Phytomedicine.2019, 59:152785
  • Sci Rep.2019, 9(1):4646
  • Oxid Med Cell Longev2019, 9056845:13
  • TCI CO.2019, US20190151257A1
  • Genes Genomics.2020, 10.1007
  • J Mol Recognit.2020, 33(2):e2819
  • Cell Metab.2020, S1550-4131(20)30002-4
  • ...
  • 生物活性
    Description: Forsythoside B inhibits inflammatory response, has antioxidant, antisepsis properties, and also has potent neuroprotective effects with a favorable therapeutic time-window, reduce of cerebral ischemia and reperfusion injury degree, attenuating blood-brain barrier (BBB) breakdown. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.
    Targets: TNF-α | IL Receptor | NF-kB | HMGB1 | MPO
    In vivo:
    Phytother Res. 2012 Jul;26(7):981-7.
    Forsythoside B protects against experimental sepsis by modulating inflammatory factors.[Pubmed: 22147417]

    METHODS AND RESULTS:
    The present study investigated the effects of Forsythoside B on an experimental model of sepsis induced by caecal ligation and puncture (CLP) in rats and elucidated the potential mechanism in cultured RAW 264.7 cells. Results showed that Forsythoside B concentration-dependently down-regulated the levels of TNF-α, IL-6 and high-mobility group-box 1 protein (HMGB1) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, inhibited the IκB kinase (IKK) pathway and modulated nuclear factor (NF)- κB. Intravenous injection (i.v.) of Forsythoside B alone or plus Imipenem reduced serum levels of TNF-α, IL-6, HMGB1, triggering receptor expressed on myeloid cells (TREM-1) and endotoxin, while the serum level of IL-10 was up-regulated and myeloperoxidase (MPO) in lung, liver and small intestine was reduced. Meanwhile, i.v. of Forsythoside B alone or plus Imipenem reduced CLP-induced lethality in rats. These data indicated that the antisepsis effect of Forsythoside B is mediated by decreasing local and systemic levels of a wide spectrum of inflammatory mediators. Its antisepsis mechanism may be that Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activition.
    CONCLUSIONS:
    Our studies enhance the case for the use of Forsythoside B in sepsis. Forsythoside B itself has promise as a therapy for the treatment of sepsis in humans.
    Phytomedicine. 2010 Jul;17(8-9):635-9.
    Cardioprotection with forsythoside B in rat myocardial ischemia-reperfusion injury: relation to inflammation response.[Pubmed: 19959348]
    The present study was undertaken to examine the effect of forsythoside B (FB) on rat myocardial ischemia-reperfusion (I/R) model and elucidate the potential mechanism.
    METHODS AND RESULTS:
    Left ventricular systolic pressure (LVSP) and +/-dp/dt(max) were detected. Blood samples were collected to determine serum levels of troponin T (Tn-T), TNF-alpha and IL-6. Hearts were harvested to assess histopathological change and infarct size, determine content of MDA, myeloperoxidase (MPO), SOD and GPx activities, analyze expression of high-mobility group box 1 (HMGB1), phosphor-I kappaB-alpha and phosphor-nuclear factor kappaB (NF-kappaB) in ischemic myocardial tissue by Western blot. Compared with control group, rats treatment with FB showed a significant recovery in myocardial function with improvement of LVSP and +/-dp/dt(max). The myocardial infarct volume, serum levels of Tn-T, TNF-alpha and IL-6, content of MDA and MPO activity in myocardial tissue were all reduced, protein expression of HMGB1, phosphor-I kappaB-alpha and phosphor-NF-kappaB were down-regulated, while attenuated the decrease of SOD and GPx activities. Besides, the infiltration of polymorph nuclear leukocytes (PMNs) and histopathological damages in myocardium were decreased in FB treated groups.
    CONCLUSIONS:
    These findings suggested that FB rescued cardiac function from I/R injury by limiting inflammation response and its antioxidant properties.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3215 mL 6.6076 mL 13.2153 mL 26.4306 mL 33.0382 mL
    5 mM 0.2643 mL 1.3215 mL 2.6431 mL 5.2861 mL 6.6076 mL
    10 mM 0.1322 mL 0.6608 mL 1.3215 mL 2.6431 mL 3.3038 mL
    50 mM 0.0264 mL 0.1322 mL 0.2643 mL 0.5286 mL 0.6608 mL
    100 mM 0.0132 mL 0.0661 mL 0.1322 mL 0.2643 mL 0.3304 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    木通苯乙醇苷B; Calceolarioside B CFN90647 105471-98-5 C23H26O11 = 478.45 20mg QQ客服:2159513211
    木通苯乙醇苷A; Calceolarioside A CFN98522 84744-28-5 C23H26O11 = 478.44 5mg QQ客服:215959384
    去鼠李糖地黄苷; Desrhamnosylmartynoside CFN89370 136055-64-6 C25H30O11 = 506.49 5mg QQ客服:2932563308
    连翘酯苷B; Forsythoside B CFN99715 81525-13-5 C34H44O19 = 756.70 20mg QQ客服:1413575084
    金石蚕苷; Poliumoside CFN99714 94079-81-9 C35H46O19 = 770.73 20mg QQ客服:1148253675
    2'-乙酰基金石蚕苷; Brandioside CFN90882 133393-81-4 C37H48O20 = 812.8 10mg QQ客服:2159513211
    松果菊苷; Echinacoside CFN98105 82854-37-3 C35H46O20 = 786.72 20mg QQ客服:1413575084
    2'-鼠李糖松果菊苷; 2'-Rhamnoechinacoside CFN95035 1422390-59-7 C41H56O24 = 932.9 10mg QQ客服:2932563308
    紫地黄甙C; Purpureaside C CFN93410 108648-07-3 C35H46O20 = 786.7 5mg QQ客服:215959384
    焦地黄苯乙醇甙A1; Jionoside A1 CFN90809 120444-60-2 C36H48O20 = 800.8 10mg QQ客服:1413575084

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