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  • 金石蚕苷

    Poliumoside

    金石蚕苷
    产品编号 CFN99714
    CAS编号 94079-81-9
    分子式 = 分子量 C35H46O19 = 770.73
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Phenylpropanoids
    植物来源 The herbs of Callicarpa dichotoma
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    金石蚕苷 CFN99714 94079-81-9 10mg QQ客服:1148253675
    金石蚕苷 CFN99714 94079-81-9 20mg QQ客服:1148253675
    金石蚕苷 CFN99714 94079-81-9 50mg QQ客服:1148253675
    金石蚕苷 CFN99714 94079-81-9 100mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Lodz University of Technology (Poland)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Universidad Veracuzana (Mexico)
  • University of Vigo (Spain)
  • The Vancouver Prostate Centre (VPC) (Canada)
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  • University of Hawaii Cancer Center (USA)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • FORTH-IMBB (Greece)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Scientific World Journal.2014, 2014:654193
  • J Pharm Biomed Anal.2016, 129:50-59
  • Asian J Beauty Cosmetol2016, 14(3):249-257
  • Phytochem Anal.2016, 27(5):296-303
  • Biomed Chromatogr.2016, 30(10):1573-81
  • Am J Chin Med.2016, 44(8):1719-1735
  • Kor. J. Pharmacogn.2016, 47(1):62-72
  • Int J Mol Sci.2017, 18(12)
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • Sci Rep.2017, 7:40345
  • Korean j.of Pharm.2017, 70-76
  • J Sci Food Agric.2017, 97(5):1656-1662
  • Pharmacognosy Magazine2018, 14(56):418-424
  • Food Quality and Safety2018, 2:213-219
  • Biosci Rep.2018, 38(4)
  • Oncology Letters2018, 4690-4696
  • Nutrients.2019, 11(4):E936
  • APMIS.2019, 127(10):688-695
  • Int J Mol Sci.2019, 20(14):E3538
  • Environ Toxicol.2019, 34(12):1354-1362
  • J Sep Sci.2019, 42(21):3352-3362
  • Korean Journal of Pharmacognosy2019, 50(4):285-290
  • Planta Med.2019, 85(9-10):766-773
  • ...
  • 生物活性
    Description: Poliumoside is a natural compound which exhibits significant inhibition of advanced glycation end product formation with IC50 value of 4.6-25.7 μM, it also exhibits great inhibitory effects on rat lens aldose reductase with IC50 values of 0.85 μM.Poliumoside has oxidant scavenging, antibacterial and hemostasis capacities, it can inhibit Biofilm-forming Staphylococcus aureus in mice.
    Targets: Antifection | Lens aldose reductase
    In vitro:
    Biol Pharm Bull. 2009 Dec;32(12):1952-6.
    Total peroxynitrite scavenging capacity of phenylethanoid and flavonoid glycosides from the flowers of Buddleja officinalis.[Pubmed: 19952410]

    METHODS AND RESULTS:
    Nine compounds, including six phenylethanoid glycosides: acteoside (1); bioside (2); echinacoside (3); poliumoside (4); phenylethyl glycoside (5); salidroside (6) and three flavonoids; linarin (7); apigenin (8); isorhoifolin (9), were isolated from the flowers of Buddleja officinalis MAXIM. (Buddlejaceae). Chemical structures were confirmed by (1)H-, and (13)C-NMR, and MS spectral methods and compared with those reported in the literature. Antioxidant activities of the methanol and water extracts, and all isolated compounds were evaluated using the total oxidant scavenging capacity (TOSC) assay against peroxynitrite.
    CONCLUSIONS:
    Results of the assay showed that the phenylethanoid glycosides, a major class of compounds of the flowers of B. officinalis, possess strong antioxidant activity. Of these, acteoside, echinacoside and poliumoside have 9.9-, 9.8- and 9.5-fold TOSC value, respectively, compared with the positive control, Trolox.
    Planta Med. 2013 Dec;79(18):1705-9.
    Caffeoylated phenylpropanoid glycosides from Brandisia hancei inhibit advanced glycation end product formation and aldose reductase in vitro and vessel dilation in larval zebrafish in vivo.[Pubmed: 24288293]
    In our continuing efforts to identify effective naturally sourced agents for diabetic complications, five caffeoylated phenylpropanoid glycosides, acteoside (1), isoacteoside (2), poliumoside (3), brandioside (4), and pheliposide (5) were isolated from the 80% EtOH extract of Brandisia hancei stems and leaves. These isolates (1-5) were subjected to an in vitro bioassay evaluating their inhibitory activity on advanced glycation end product formation and rat lens aldose reductase activity.
    METHODS AND RESULTS:
    All tested compounds exhibited significant inhibition of advanced glycation end product formation with IC50 values of 4.6-25.7 μM, compared with those of aminoguanidine (IC50=1,056 μM) and quercetin (IC50=28.4 μM) as positive controls. In the rat lens aldose reductase assay, acteoside, isoacteoside, and poliumoside exhibited greater inhibitory effects on rat lens aldose reductase with IC50 values of 0.83, 0.83, and 0.85 μM, respectively, than those of the positive controls, 3,3-tetramethyleneglutaric acid (IC50=4.03 μM) and quercetin (IC50=7.2 μM). In addition, the effect of acteoside on the dilation of hyaloid-retinal vessels induced by high glucose in larval zebrafish was investigated. Acteoside reduced the diameters of high glucose-induced hyaloid-retinal vessels by 69% at 10 μM and 81% at 20 μM, compared to the high glucose-treated control group.
    CONCLUSIONS:
    These results suggest that B. hancei and its active components might be beneficial in the treatment and prevention of diabetic vascular complications.
    In vivo:
    International Eurasia Pharmacy Congress. 2015, 9.
    Poliumoside from Teucrium polium Inhibit Biofilm-forming Staphylococcus aureus in Mice.[Reference: WebLink]
    Previous studies have demonstrated the therapeutic efficacy of Teucrium species, family Lamiaceae, as antibacterial. T. polium has been used for wound healing and the extract has shown a marked antibacterial activity against both Gram-positive and Gram-negative bacteria.
    METHODS AND RESULTS:
    The focus of this study was to mine for T. polium secondary metabolites with antibiotic activity against the biofilm forming S. aureus. Purification and structural elucidation were based on chromatographic and spectroscopic IR, UV, 1D and 2D NMR, and ESI-MS data analysis. The stereochemistry was established by X-ray crystallography and modified Mosher’s method. Antibacterial activity was assessed based on Biofilm Inhibition Assay and confocal laser scanning microscopy. Four new sesquiterpenes together with twelve known were characterized. Antibacterial activity of three metabolites was observed in μMol range against biofilm forming S. aureus.
    CONCLUSIONS:
    In vivo study using mice, Poliumoside inhibited the biofilm forming S. aureus infections. The potential application of these compounds is preventing biofilm development by coating susceptible surfaces such as urinary and/or intravenous catheters, or dental sealing.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2975 mL 6.4874 mL 12.9747 mL 25.9494 mL 32.4368 mL
    5 mM 0.2595 mL 1.2975 mL 2.5949 mL 5.1899 mL 6.4874 mL
    10 mM 0.1297 mL 0.6487 mL 1.2975 mL 2.5949 mL 3.2437 mL
    50 mM 0.0259 mL 0.1297 mL 0.2595 mL 0.519 mL 0.6487 mL
    100 mM 0.013 mL 0.0649 mL 0.1297 mL 0.2595 mL 0.3244 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2'-乙酰基金石蚕苷; Brandioside CFN90882 133393-81-4 C37H48O20 = 812.8 10mg QQ客服:1413575084
    松果菊苷; Echinacoside CFN98105 82854-37-3 C35H46O20 = 786.72 20mg QQ客服:3257982914
    2'-鼠李糖松果菊苷; 2'-Rhamnoechinacoside CFN95035 1422390-59-7 C41H56O24 = 932.9 10mg QQ客服:215959384
    紫地黄甙C; Purpureaside C CFN93410 108648-07-3 C35H46O20 = 786.7 5mg QQ客服:2159513211
    焦地黄苯乙醇甙A1; Jionoside A1 CFN90809 120444-60-2 C36H48O20 = 800.8 10mg QQ客服:215959384
    焦地黄苯乙醇甙B1; Jionoside B1 CFN90729 120406-37-3 C37H50O20 = 814.78 10mg QQ客服:1413575084
    管花苷A; Tubuloside A CFN90669 112516-05-9 C37H48O21 = 828.76 20mg QQ客服:2932563308
    管花肉苁蓉苷C1; Cistantubuloside C1 CFN95121 620632-36-2 C35H46O21 = 802.7 10mg QQ客服:2159513211
    肉苁蓉苷A; Cistanoside A CFN90526 93236-42-1 C36H48O20 = 800.75 10mg QQ客服:2159513211
    安格洛苷C; 安格洛甙C; Angoroside C CFN98149 115909-22-3 C36H48O19 = 784.75 20mg QQ客服:3257982914

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