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  • 25-环木菠萝烯-3,24-二醇

    Cycloart-25-ene-3,24-diol

    25-环木菠萝烯-3,24-二醇
    产品编号 CFN99054
    CAS编号 10388-48-4
    分子式 = 分子量 C30H50O2 = 442.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Euphorbia segetalis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    25-环木菠萝烯-3,24-二醇 CFN99054 10388-48-4 1mg QQ客服:2159513211
    25-环木菠萝烯-3,24-二醇 CFN99054 10388-48-4 5mg QQ客服:2159513211
    25-环木菠萝烯-3,24-二醇 CFN99054 10388-48-4 10mg QQ客服:2159513211
    25-环木菠萝烯-3,24-二醇 CFN99054 10388-48-4 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
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  • Imperial College London (United Kingdom)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci. 2014, 15(5):8443-57
  • Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
  • J Separation Science & Technology2016, 51:1579-1588
  • Acta Pharmaceutica Hungarica2016, 86:35-40
  • J Ethnopharmacol.2017, 209:305-316
  • Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
  • RSC Advances2017, 86
  • Industrial Crops and Products2017, 95:286-295
  • BMC Plant Biol.2018, 18(1):122
  • BMC Complement Altern Med.2018, 18(1):303
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • Molecules.2018, 23(7):E1659
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • Front Microbiol.2019, 10:2806
  • Pharmacognosy Journal2019, 11,6:1235-1241
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1126-1127:121743
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • Int J Mol Sci.2019, 21(1):E265
  • Phytother Res.2019, 33(3):676-689
  • Biomed Chromatogr.2019, 8:e4774
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • Genes Genomics.2020, 10.1007
  • Food Research International2020, 108987
  • ...
  • 生物活性
    Description: (24R)-Cycloart-25-ene-3beta,24-diol may be an anti-tumor promoter, it exhibits inhibitory effects on both Epstein-Barr virus early antigen (EBV-EA) and (+/-)-(E)-methtyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3- hexemide (NOR 1) activation.
    Targets: NOR 1
    In vitro:
    J Nat Prod. 2007 Jun;70(6):918-22.
    Cancer chemopreventive effects of cycloartane-type and related triterpenoids in in vitro and in vivo models.[Pubmed: 17503850 ]

    METHODS AND RESULTS:
    Forty-eight natural and semisynthetic cycloartane-type and related triterpenoids have been evaluated for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells as a primary screening test for anti-tumor promoters. In addition, these triterpenoids have been tested for their inhibitory effects on activation of (+/-)-(E)-methtyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor, as a primary screening test for anti-tumor initiators. All of the compounds tested exhibited inhibitory effects on both EBV-EA and NOR 1 activation.
    CONCLUSIONS:
    Six of these compounds having a C-24 hydroxylated side chain, viz., (24R)-cycloart-25-ene-3beta,24-diol (Cycloart-25-ene-3,24-diol ,9), (24R)-cycloartane-3beta,24,25-triol (11), (24S)-cycloartane-3beta,24,25-triol (12), (24xi)-24-methylcycloartane-3beta,24,241-triol (14), (24xi)-241-methoxy-24-methylcycloartane-3beta,24-diol (15), and (24xi)-24,25-dihydroxycycloartan-3-one (27), showed higher inhibitory effects than the others tested on both EBV-EA (IC50 values of 6.1-7.4 nM) and NOR 1 activation. Furthermore, compounds 14 and 15 exhibited inhibitory effects on skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2589 mL 11.2943 mL 22.5887 mL 45.1773 mL 56.4717 mL
    5 mM 0.4518 mL 2.2589 mL 4.5177 mL 9.0355 mL 11.2943 mL
    10 mM 0.2259 mL 1.1294 mL 2.2589 mL 4.5177 mL 5.6472 mL
    50 mM 0.0452 mL 0.2259 mL 0.4518 mL 0.9035 mL 1.1294 mL
    100 mM 0.0226 mL 0.1129 mL 0.2259 mL 0.4518 mL 0.5647 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    黑升麻苷H-2; Cimicifugoside H2 CFN92972 161097-77-4 C35H54O10 = 634.8 5mg QQ客服:2932563308
    升麻酮醇-3-O-α-L-吡喃阿拉伯糖苷; Cimicidanol 3-O-alpha-L-arabinoside CFN90863 161207-05-2 C35H52O9 = 616.8 20mg QQ客服:1148253675
    黑升麻苷H-1; Cimicifugoside H1 CFN92973 163046-73-9 C35H52O9 = 616.78 5mg QQ客服:1413575084
    23-O-Acetylshengmanol 3-O-beta-D-xyloside; 23-O-Acetylshengmanol 3-O-beta-D-xyloside CFN92970 62498-88-8 C37H58O10 = 662.85 5mg QQ客服:215959384
    (3beta,23E)-9,19-环羊毛甾-23-烯-3,25-二醇; Cycloart-23-ene-3,25-diol CFN90498 14599-48-5 C30H50O2 = 442.72 5mg QQ客服:1148253675
    (3beta,22E)-9,19-环羊毛甾-22-烯-3,25-二醇; Cycloart-22-ene-3,25-diol CFN97555 97456-49-0 C30H50O2 = 442.7 5mg QQ客服:2932563308
    环羊毛甾-24-烯-1alpha,2alpha,3beta-三醇; Cycloart-24-ene-1alpha,2alpha,3beta-triol CFN91991 942407-97-8 C30H50O3 = 458.72 5mg QQ客服:1413575084
    29-去甲羊毛甾-8,24-二烯-1alpha,2alpha,3beta-三醇; 29-Norlanosta-8,24-diene-1alpha,2alpha,3beta-triol CFN91990 119765-92-3 C29H48O3 = 444.69 5mg QQ客服:3257982914
    25-羟基环木菠萝-23-烯-3-酮; 25-Hydroxycycloart-23-en-3-one CFN99613 148044-47-7 C30H48O2 = 440.7 5mg QQ客服:1148253675
    29-去甲环安坦-23-烯-3,25-二醇; 29-Norcycloart-23-ene-3,25-diol CFN97849 115040-04-5 C29H48O2 = 428.7 5mg QQ客服:1148253675

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