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    环羊毛甾-24-烯-1alpha,2alpha,3beta-三醇

    Cycloart-24-ene-1alpha,2alpha,3beta-triol

    环羊毛甾-24-烯-1alpha,2alpha,3beta-三醇
    产品编号 CFN91991
    CAS编号 942407-97-8
    分子式 = 分子量 C30H50O3 = 458.72
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Pongamia pinnata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    环羊毛甾-24-烯-1alpha,2alpha,3beta-三醇 CFN91991 942407-97-8 1mg QQ客服:1413575084
    环羊毛甾-24-烯-1alpha,2alpha,3beta-三醇 CFN91991 942407-97-8 5mg QQ客服:1413575084
    环羊毛甾-24-烯-1alpha,2alpha,3beta-三醇 CFN91991 942407-97-8 10mg QQ客服:1413575084
    环羊毛甾-24-烯-1alpha,2alpha,3beta-三醇 CFN91991 942407-97-8 20mg QQ客服:1413575084
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
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    IF=13.297(2019)

    PMID: 28005066

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  • Braz J Med Biol Res. 2016, 49(7)
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  • Ulm University Medical Center2020, doi: 10.18725.
  • ...
  • 生物活性
    Description: Cycloartan-24-ene-1α,2α,3β-triol, as a potential anticancer drug, it exerts significantly pro-apoptotic activity against human hormone-independent prostatic cancer.
    Targets: Bcl-2/Bax | Caspase
    In vitro:
    Oncology Reports, 2015, 33(3):1107-1114.
    Cycloartan-24-ene-1α,2α,3β-triol, a cycloartane-type triterpenoid from the resinous exudates of Commiphora myrrha, induces apoptosis in human prostatic cancer PC-3 cells.[Reference: WebLink]
    Plant-derived antitumor drugs are currently used in chemotherapy. Cycloartane triterpenoids have shown a cytotoxic effect on human prostate cancer cells. The aim of the present study was to isolate a cycloartane triterpenoid from Commiphora myrrha and evaluate its anticancer potential.
    METHODS AND RESULTS:
    Cycloartan-24-ene-1α,2α,3β-triol (Cycloart-24-ene-1alpha,2alpha,3beta-triol ,MY-1) was isolated from Commiphora myrrha, and its structure was determined through 1H and 13C nuclear magnetic resonance spectroscopy. The cytotoxic and apoptotic effects of MY-1 on human prostatic cancer PC-3 cells were estimated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometric analysis and terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) staining assay, and the expression of apoptotic-related proteins were evaluated by western blotting. MY-1 showed cytotoxic activity on PC-3 cells in a concentration-dependent manner with an IC50 value of 9.6 µM at 24 h. MY-1 induced cell cycle arrest and apoptosis. Western blot analysis revealed that MY-1 regulated the expression levels of B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), p53 and caspase-3 in the PC-3 cells.
    CONCLUSIONS:
    These findings indicate that MY-1 exerts significantly pro-apoptotic activity against human hormone-independent prostatic cancer and support MY-1 as a potential anticancer drug.
    Journal of Chinese medicinal materials, 2013, 36(10):1640-1643.
    Antiproliferative effect of cycloartane-type triterpenoid from myrrh against human prostate cancer cells.[Pubmed: 24761675]
    To investigate the antiproliferative effect of cycloartan-24-ene-1alpha, 2alpha, 3beta-triol(Cycloart-24-ene-1alpha,2alpha,3beta-triol ) from Myrrh against human prostate cancer cells.
    METHODS AND RESULTS:
    Morphological changes of compound-treated human prostate PC3 cells were determined by staining cells with Hoechst. The cell cycle progression and apoptosis were evaluated using flow cytometry assay. Apoptosis related protein levels were analyzed using Western blotting. Treatment of PC3 cells with cycloartan-24-ene-1alpha,2alpha,3beta-triol caused an increase ratio of apoptotic cells, which was verified by flow cytometry. It was also found that cycloartan-24-ene-1alpha,2alpha, 3beta-triol arrested cell cycle at the G0/G1 phase. Apoptosis related proteins, such as BCL-2, BAX, Caspase-3 and Caspase-9 were changed.
    CONCLUSIONS:
    These observes data indicate that cycloartan-24-ene-1alpha,2alpha,3beta-triol inhibit the proliferation of PC3 cells via induction of apoptosis and cell cycle arrest.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.18 mL 10.8999 mL 21.7998 mL 43.5996 mL 54.4995 mL
    5 mM 0.436 mL 2.18 mL 4.36 mL 8.7199 mL 10.8999 mL
    10 mM 0.218 mL 1.09 mL 2.18 mL 4.36 mL 5.4499 mL
    50 mM 0.0436 mL 0.218 mL 0.436 mL 0.872 mL 1.09 mL
    100 mM 0.0218 mL 0.109 mL 0.218 mL 0.436 mL 0.545 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (3beta,23E)-9,19-环羊毛甾-23-烯-3,25-二醇; Cycloart-23-ene-3,25-diol CFN90498 14599-48-5 C30H50O2 = 442.72 5mg QQ客服:2159513211
    (3beta,22E)-9,19-环羊毛甾-22-烯-3,25-二醇; Cycloart-22-ene-3,25-diol CFN97555 97456-49-0 C30H50O2 = 442.7 5mg QQ客服:2932563308
    环羊毛甾-24-烯-1alpha,2alpha,3beta-三醇; Cycloart-24-ene-1alpha,2alpha,3beta-triol CFN91991 942407-97-8 C30H50O3 = 458.72 5mg QQ客服:2932563308
    29-去甲羊毛甾-8,24-二烯-1alpha,2alpha,3beta-三醇; 29-Norlanosta-8,24-diene-1alpha,2alpha,3beta-triol CFN91990 119765-92-3 C29H48O3 = 444.69 5mg QQ客服:2056216494
    25-羟基环木菠萝-23-烯-3-酮; 25-Hydroxycycloart-23-en-3-one CFN99613 148044-47-7 C30H48O2 = 440.7 5mg QQ客服:2056216494
    29-去甲环安坦-23-烯-3,25-二醇; 29-Norcycloart-23-ene-3,25-diol CFN97849 115040-04-5 C29H48O2 = 428.7 5mg QQ客服:1457312923
    环安坦-3,24,25-三醇; Cycloartane-3,24,25-triol CFN98972 57576-29-1 C30H52O3 = 460.7 5mg QQ客服:2159513211
    (24S)-环安坦-3,24,25-三醇24,25-缩丙酮; (24S)-Cycloartane-3,24,25-triol 24,25-acetonide CFN98973 57576-31-5 C33H56O3 = 500.8 5mg QQ客服:2932563308
    24,25-二羟基环木菠萝烷-3-酮; 24,25-Dihydroxycycloartan-3-one CFN99653 155060-48-3 C30H50O3 = 458.7 5mg QQ客服:2056216494
    栀子花乙酸; Gardenolic acid B CFN96838 108864-53-5 C30H46O5 = 486.69 5mg QQ客服:2932563308

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