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  • 环安坦-3,24,25-三醇

    Cycloartane-3,24,25-triol

    环安坦-3,24,25-三醇
    产品编号 CFN98972
    CAS编号 57576-29-1
    分子式 = 分子量 C30H52O3 = 460.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The barks of Aphanamixis polystachya
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    环安坦-3,24,25-三醇 CFN98972 57576-29-1 1mg QQ客服:1148253675
    环安坦-3,24,25-三醇 CFN98972 57576-29-1 5mg QQ客服:1148253675
    环安坦-3,24,25-三醇 CFN98972 57576-29-1 10mg QQ客服:1148253675
    环安坦-3,24,25-三醇 CFN98972 57576-29-1 20mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Universita' Degli Studi Di Cagliari (Italy)
  • University of Pretoria (South Africa)
  • National Cancer Institute (USA)
  • University of Illinois (USA)
  • John Innes Centre (United Kingdom)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Celltrion Chemical Research Institute (Korea)
  • S.N.D.T. Women's University (India)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Shanghai University of TCM (China)
  • Universidade Católica Portuguesa (Portugal)
  • Sant Gadge Baba Amravati University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Asian Journal of Chemistry2014, 26(8):2425
  • Inflammation2015, 38(1):445-55
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • University of Limpopo2016, 1777
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • Universidade Estadual Paulista2017, 42785
  • Phytochemistry Letters2017, 449-455
  • Evid Based Complement Alternat Med.2018, 2018:4580627
  • Molecules.2018, 23(11):E2837
  • Molecules.2018, 23(2)
  • Food Chem.2018, 262:78-85
  • Biofactors.2018, 44(2):168-179
  • Toxicol In Vitro.2018, 52:94-105
  • Biochemical Systematics and Ecology2018, 81
  • Molecules.2019, 24(22):E4022
  • Food Chem.2019, 279:80-87
  • Planta Med.2019, 85(4):347-355
  • Sci Rep.2019, 9(1):4342
  • Biomolecules.2019, 9(11):E696
  • Food Research International2020, 108987
  • Food Chem Toxicol.2020, 135:110863
  • ...
  • 生物活性
    Description: Cycloartane-3,24,25-triol has potential for development as an anti-cancer agent against prostate cancer. It reduces the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively.
    Targets: ATPase
    In vitro:
    Cancer Cell Int. 2012 Nov 14;12(1):46.
    Cycloartane-3,24,25-triol inhibits MRCKα kinase and demonstrates promising anti prostate cancer activity in vitro.[Pubmed: 23151005]
    Given the high occurrence of prostate cancer worldwide and one of the major sources of the discovery of new lead molecules being medicinal plants, this research undertook to investigate the possible anti-cancer activity of two natural cycloartanes; cycloartane-3,24,25-diol (extracted in our lab from Tillandsia recurvata) and Cycloartane-3,24,25-triol (purchased). The inhibition of MRCKα kinase has emerged as a potential solution to restoring the tight regulation of normal cellular growth, the loss of which leads to cancer cell formation.
    METHODS AND RESULTS:
    Kinase inhibition was investigated using competition binding (to the ATP sites) assays which have been previously established and authenticated and cell proliferation was measured using the WST-1 assay. Cycloartane-3,24,25-triol demonstrated strong selectivity towards the MRCKα kinase with a Kd50 of 0.26 μM from a total of 451 kinases investigated. Cycloartane-3,24,25-triol reduced the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively.
    CONCLUSIONS:
    These results will prove useful in drug discovery as Cycloartane-3,24,25-triol has shown potential for development as an anti-cancer agent against prostate cancer.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1706 mL 10.853 mL 21.7061 mL 43.4122 mL 54.2652 mL
    5 mM 0.4341 mL 2.1706 mL 4.3412 mL 8.6824 mL 10.853 mL
    10 mM 0.2171 mL 1.0853 mL 2.1706 mL 4.3412 mL 5.4265 mL
    50 mM 0.0434 mL 0.2171 mL 0.4341 mL 0.8682 mL 1.0853 mL
    100 mM 0.0217 mL 0.1085 mL 0.2171 mL 0.4341 mL 0.5427 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    环羊毛甾-24-烯-1alpha,2alpha,3beta-三醇; Cycloart-24-ene-1alpha,2alpha,3beta-triol CFN91991 942407-97-8 C30H50O3 = 458.72 5mg QQ客服:2159513211
    29-去甲羊毛甾-8,24-二烯-1alpha,2alpha,3beta-三醇; 29-Norlanosta-8,24-diene-1alpha,2alpha,3beta-triol CFN91990 119765-92-3 C29H48O3 = 444.69 5mg QQ客服:1148253675
    25-羟基环木菠萝-23-烯-3-酮; 25-Hydroxycycloart-23-en-3-one CFN99613 148044-47-7 C30H48O2 = 440.7 5mg QQ客服:1413575084
    29-去甲环安坦-23-烯-3,25-二醇; 29-Norcycloart-23-ene-3,25-diol CFN97849 115040-04-5 C29H48O2 = 428.7 5mg QQ客服:1413575084
    环安坦-3,24,25-三醇; Cycloartane-3,24,25-triol CFN98972 57576-29-1 C30H52O3 = 460.7 5mg QQ客服:2159513211
    (24S)-环安坦-3,24,25-三醇24,25-缩丙酮; (24S)-Cycloartane-3,24,25-triol 24,25-acetonide CFN98973 57576-31-5 C33H56O3 = 500.8 5mg QQ客服:1413575084
    24,25-二羟基环木菠萝烷-3-酮; 24,25-Dihydroxycycloartan-3-one CFN99653 155060-48-3 C30H50O3 = 458.7 5mg QQ客服:2932563308
    栀子花乙酸; Gardenolic acid B CFN96838 108864-53-5 C30H46O5 = 486.69 5mg QQ客服:1413575084
    黑升麻苷H-2; Cimicifugoside H2 CFN92972 161097-77-4 C35H54O10 = 634.8 5mg QQ客服:1413575084
    升麻酮醇-3-O-α-L-吡喃阿拉伯糖苷; Cimicidanol 3-O-alpha-L-arabinoside CFN90863 161207-05-2 C35H52O9 = 616.8 20mg QQ客服:3257982914

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