• 中药标准品生产商,产品定制服务
  • 环安坦-3,24,25-三醇

    Cycloartane-3,24,25-triol

    环安坦-3,24,25-三醇
    产品编号 CFN98972
    CAS编号 57576-29-1
    分子式 = 分子量 C30H52O3 = 460.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The barks of Aphanamixis polystachya
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    环安坦-3,24,25-三醇 CFN98972 57576-29-1 1mg QQ客服:2159513211
    环安坦-3,24,25-三醇 CFN98972 57576-29-1 5mg QQ客服:2159513211
    环安坦-3,24,25-三醇 CFN98972 57576-29-1 10mg QQ客服:2159513211
    环安坦-3,24,25-三醇 CFN98972 57576-29-1 20mg QQ客服:2159513211
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Center for protein Engineering (CIP) (Belgium)
  • Monash University (Australia)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Universiti Sains Malaysia (Malaysia)
  • Nanjing University of Chinese Medicine (China)
  • Universit?t Basel (Switzerland)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Northeast Normal University Changchun (China)
  • University of Sao Paulo (Brazil)
  • Periyar University (India)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • MTT Agrifood Research Finland (Finland)
  • National Research Council of Canada (Canada)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nat Prod Sci.2014, 20(3):182-190
  • J Pharm Biomed Anal.2016, 129:50-59
  • Br J Pharmacol.2016, 173(2):396-410
  • Mediators Inflamm.2016, 2016:7216912
  • Mol Immunol. 2016, 78:121-132
  • Exp Parasitol.2017, 183:160-166
  • J Ethnopharmacol.2017, 206:73-77
  • Food Chem.2017, 228:301-314
  • J Nat Med.2017, 71(2):457-462
  • Anal Chim Acta.2018, 1039:162-171
  • Neurochem Int.2018, 121:114-124
  • PLoS One.2018, 13(3):e0193386
  • Int J Mol Sci.2019, 20(8):E1855
  • J Ethnopharmacol.2019, 241:112025
  • J Ethnopharmacol.2019, 244:112074
  • Journal of Third Military Medical University2019, 41(2):110-115
  • Oncol Rep.2019, 41(4):2453-2463
  • Phytomedicine.2019, 56:48-56
  • Phytomedicine.2019, 57:95-104
  • Phytomedicine.2019, 59:152785
  • Planta Med.2019, 85(4):347-355
  • Industrial Crops and Products2020, 146:112186
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • ...
  • 生物活性
    Description: Cycloartane-3,24,25-triol has potential for development as an anti-cancer agent against prostate cancer. It reduces the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively.
    Targets: ATPase
    In vitro:
    Cancer Cell Int. 2012 Nov 14;12(1):46.
    Cycloartane-3,24,25-triol inhibits MRCKα kinase and demonstrates promising anti prostate cancer activity in vitro.[Pubmed: 23151005]
    Given the high occurrence of prostate cancer worldwide and one of the major sources of the discovery of new lead molecules being medicinal plants, this research undertook to investigate the possible anti-cancer activity of two natural cycloartanes; cycloartane-3,24,25-diol (extracted in our lab from Tillandsia recurvata) and Cycloartane-3,24,25-triol (purchased). The inhibition of MRCKα kinase has emerged as a potential solution to restoring the tight regulation of normal cellular growth, the loss of which leads to cancer cell formation.
    METHODS AND RESULTS:
    Kinase inhibition was investigated using competition binding (to the ATP sites) assays which have been previously established and authenticated and cell proliferation was measured using the WST-1 assay. Cycloartane-3,24,25-triol demonstrated strong selectivity towards the MRCKα kinase with a Kd50 of 0.26 μM from a total of 451 kinases investigated. Cycloartane-3,24,25-triol reduced the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively.
    CONCLUSIONS:
    These results will prove useful in drug discovery as Cycloartane-3,24,25-triol has shown potential for development as an anti-cancer agent against prostate cancer.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1706 mL 10.853 mL 21.7061 mL 43.4122 mL 54.2652 mL
    5 mM 0.4341 mL 2.1706 mL 4.3412 mL 8.6824 mL 10.853 mL
    10 mM 0.2171 mL 1.0853 mL 2.1706 mL 4.3412 mL 5.4265 mL
    50 mM 0.0434 mL 0.2171 mL 0.4341 mL 0.8682 mL 1.0853 mL
    100 mM 0.0217 mL 0.1085 mL 0.2171 mL 0.4341 mL 0.5427 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    升麻酮醇-3-O-α-L-吡喃阿拉伯糖苷; Cimicidanol 3-O-alpha-L-arabinoside CFN90863 161207-05-2 C35H52O9 = 616.8 20mg QQ客服:215959384
    黑升麻苷H-1; Cimicifugoside H1 CFN92973 163046-73-9 C35H52O9 = 616.78 5mg QQ客服:2932563308
    23-O-Acetylshengmanol 3-O-beta-D-xyloside; 23-O-Acetylshengmanol 3-O-beta-D-xyloside CFN92970 62498-88-8 C37H58O10 = 662.85 5mg QQ客服:2159513211
    (3beta,23E)-9,19-环羊毛甾-23-烯-3,25-二醇; Cycloart-23-ene-3,25-diol CFN90498 14599-48-5 C30H50O2 = 442.72 5mg QQ客服:1148253675
    (3beta,22E)-9,19-环羊毛甾-22-烯-3,25-二醇; Cycloart-22-ene-3,25-diol CFN97555 97456-49-0 C30H50O2 = 442.7 5mg QQ客服:2932563308
    环羊毛甾-24-烯-1alpha,2alpha,3beta-三醇; Cycloart-24-ene-1alpha,2alpha,3beta-triol CFN91991 942407-97-8 C30H50O3 = 458.72 5mg QQ客服:215959384
    29-去甲羊毛甾-8,24-二烯-1alpha,2alpha,3beta-三醇; 29-Norlanosta-8,24-diene-1alpha,2alpha,3beta-triol CFN91990 119765-92-3 C29H48O3 = 444.69 5mg QQ客服:215959384
    25-羟基环木菠萝-23-烯-3-酮; 25-Hydroxycycloart-23-en-3-one CFN99613 148044-47-7 C30H48O2 = 440.7 5mg QQ客服:1148253675
    29-去甲环安坦-23-烯-3,25-二醇; 29-Norcycloart-23-ene-3,25-diol CFN97849 115040-04-5 C29H48O2 = 428.7 5mg QQ客服:1413575084
    环安坦-3,24,25-三醇; Cycloartane-3,24,25-triol CFN98972 57576-29-1 C30H52O3 = 460.7 5mg QQ客服:2932563308

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产