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  • 补骨脂甲素

    Bavachin

    补骨脂甲素
    产品编号 CFN98007
    CAS编号 19879-32-4
    分子式 = 分子量 C20H20O4 = 324.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The fruits of Psoralea corylifolia L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    补骨脂甲素 CFN98007 19879-32-4 10mg QQ客服:1413575084
    补骨脂甲素 CFN98007 19879-32-4 20mg QQ客服:1413575084
    补骨脂甲素 CFN98007 19879-32-4 50mg QQ客服:1413575084
    补骨脂甲素 CFN98007 19879-32-4 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • University of Vienna (Austria)
  • University of Malaya (Malaysia)
  • Seoul National University (Korea)
  • Aveiro University (Portugal)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Indian Institute of Science (India)
  • University of Madras (India)
  • Chang Gung University (Taiwan)
  • University of Lodz (Poland)
  • Kyung Hee University (Korea)
  • National Research Council of Canada (Canada)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • University of Liège (Belgium)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Am J Chin Med.2015, 30:1-22
  • J Exp Bot.2016, 67(12):3777-88
  • Onco Targets Ther.2017, 10:3467-3474
  • Pharmacognosy Magazine2017, 13(52):868-874
  • Plant Methods.2017, 13:108
  • Research on Crops.2017, 18(2)
  • University of Central Lancashire2017, 20472
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • Front Pharmacol.2017, 8:205
  • Arch Toxicol.2017, 91(10):3225-3245
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Microchemical Journal2018, 137:168-173
  • Exp Parasitol.2018, 194:67-78
  • J Liq Chromatogr R T2018, 41(12):761-769
  • Eur J Pharmacol.2018, 832:96-103
  • J Adv Res.2019, 17:85-94
  • Int J Mol Sci.2019, 21(1):E265
  • Molecules.2019, 24(16):E3003
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • Food and Fermentation Industries2019, 45(7):45-51
  • Phytomedicine.2019, 62:152962
  • Planta Med.2019, 85(4):347-355
  • Antioxidants (Basel).2020, 9(2):E99
  • ...
  • 生物活性
    Description: Bavachin is a phytoestrogen that activates the estrogen receptors ERα and ERβ with EC50s of 320 and 680 nM, respectively. It is a cholesterol acyltransferase inhibitor, may have therapeutic potential for type 2 diabetes by activating insulin signaling pathways. Bavachin can stimulate the genetic expression of VEGF in PB,and directly help the fracture healing, and potentially protect cartilage from inflammation-mediated damage in joints of osteoarthritis patients through decreasing IL-1β-induced activation of IKK-IκBα-NF-κB signaling pathway. Bavachin has suppressive effects against pigmentation by melanin in the skin.
    Targets: NF-kB | p65 | IkB | VEGFR | IL Receptor | AP-1 | AMPK | PPAR | GLUT | Akt | IKK | Estrogen receptor α | Estrogen receptor β
    In vivo:
    Int J Mol Sci. 2016 Apr 8;17(4):527.
    Bavachin from Psoralea corylifolia Improves Insulin-Dependent Glucose Uptake through Insulin Signaling and AMPK Activation in 3T3-L1 Adipocytes.[Pubmed: 27070585]
    The fruit of Psoralea corylifolia L. (Fabaceae) (PC), known as "Bo-Gol-Zhee" in Korea has been used as traditional medicine. Ethanol and aqueous extracts of PC have an anti-hyperglycemic effect by increasing plasma insulin levels and decreasing blood glucose and total plasma cholesterol levels in type 2 diabetic rats.
    METHODS AND RESULTS:
    In this study, we purified six compounds from PC and investigated their anti-diabetic effect. Among the purified compounds, bavachin most potently accumulated lipids during adipocyte differentiation. Intracellular lipid accumulation was measured by Oil Red-O (ORO) cell staining to investigate the effect of compounds on adipogenesis. Consistently, bavachin activated gene expression of adipogenic transcriptional factors, proliferator-activated receptorγ (PPARγ) and CCAAT/enhancer binding protein-α (C/EBPα). Bavachin also increased adiponectin expression and secretion in adipocytes. Moreover, bavachin increased insulin-induced glucose uptake by differentiated adipocytes and myoblasts. In differentiated adipocytes, we found that bavachin enhanced glucose uptake via glucose transporter 4 (GLUT4) translocation by activating the Akt and 5'AMP-activated protein kinase (AMPK) pathway in the presence or absence of insulin.
    CONCLUSIONS:
    These results suggest that bavachin from Psoralea corylifolia might have therapeutic potential for type 2 diabetes by activating insulin signaling pathways.
    Journal of Emergency in Traditional Chinese Medicine, 2014,  23(9):1585-8.
    Effect of Brain Injury and Bavachin on 5-HT and VEGF of Rats with Tibial Fracture.[Reference: WebLink]
    To observe the influence of brain injury and Bavachin on 5-HT and VEGF during the healing of rats′ tibial fracture.
    METHODS AND RESULTS:
    42 healthy male SD rats were selected and randomly divided into 7groups.For normal control group,blood was drawn on the third day.For the other groups,blood was drawn on postoperative day 3,7,14,21,28,and 35.And then centrifuged supernatant was acquired to determine the amount of VEGF and 5-HT by ELISA.(1) 5-TH:The concentration in the brain injury group and facture +brain injury group peaked in the first week,before it gradually declined in the following week.It reached a plateau 3 weeks later.Comparisons between the three fracture + Bavachin groups(all three doses) and the fracture group in one and two weeks have shown no significance(P 0.05).(2)VEGF:The concentrations in all treatment groups were higher than those in the control group.The concentration in fracture + brain injury group was higher than that in fracture group or brain injury group.After a week,the concentration of VEGF was in direct proportion to those of the Bavachin in the 3 facture + Bavachin groups.5 weeks later,they headed to similar concentration.
    CONCLUSIONS:
    The brain injury can induce increased VEGF content in peripheral blood to promote fracture healing.Bavachin in the blood can stimulate the genetic expression of VEGF in PB,and directly help the fracture healing.Also,the high does and the middle dose have better healing efficacy.At the beginning of brain injury,5-HT increases and is released into the cerebrum capillaries,accelerating the healing of fracture.However later 5-HT goes through the blood cerebrospinal fluid barrier and its concentration in the nervous centralis declines,resulting in the slowdown of fracture healing.Bavachin has no significant influence on the 5-HT concentration during the fracture healing.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0826 mL 15.4131 mL 30.8261 mL 61.6523 mL 77.0654 mL
    5 mM 0.6165 mL 3.0826 mL 6.1652 mL 12.3305 mL 15.4131 mL
    10 mM 0.3083 mL 1.5413 mL 3.0826 mL 6.1652 mL 7.7065 mL
    50 mM 0.0617 mL 0.3083 mL 0.6165 mL 1.233 mL 1.5413 mL
    100 mM 0.0308 mL 0.1541 mL 0.3083 mL 0.6165 mL 0.7707 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6-异戊烯基樱花亭; 6-Prenylsakuranetin CFN92901 261776-61-8 C21H22O5 = 354.40 5mg QQ客服:1413575084
    8-异戊烯基柚皮素; 8-Prenylnaringenin CFN92016 53846-50-7 C20H20O5 = 340.4 10mg QQ客服:3257982914
    异黄腐醇; Isoxanthohumol CFN90768 70872-29-6 C21H22O5 = 354.4 10mg QQ客服:2159513211
    6-香叶草基柚皮素; 6-Geranylnaringenin CFN92019 97126-57-3 C25H28O5 = 408.5 5mg QQ客服:1148253675
    6,8-二异戊二烯基柚皮素; 6,8-Diprenylnaringenin CFN92018 68236-11-3 C25H28O5 = 408.5 5mg QQ客服:2932563308
    苦参醇A; Kushenol A CFN92000 99217-63-7 C25H28O5 = 408.5 5mg QQ客服:1413575084
    甲基补骨脂黄酮; Bavachinin CFN98006 19879-30-2 C21H22O4 = 338.4 20mg QQ客服:3257982914
    5-Dehydroxyparatocarpin K; 5-Dehydroxyparatocarpin K CFN96117 124858-37-3 C20H18O4 = 322.4 5mg QQ客服:1413575084
    异补骨脂黄酮; Isobavachin CFN98400 31524-62-6 C20H20O4 = 324.4 20mg QQ客服:3257982914
    光甘草宁; Glabranin CFN98659 41983-91-9 C20H20O4 = 324.4 5mg QQ客服:3257982914

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