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  • 甲基补骨脂黄酮

    Bavachinin

    甲基补骨脂黄酮
    产品编号 CFN98006
    CAS编号 19879-30-2
    分子式 = 分子量 C21H22O4 = 338.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The seeds of Psoralea corylifolia L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    甲基补骨脂黄酮 CFN98006 19879-30-2 10mg QQ客服:1148253675
    甲基补骨脂黄酮 CFN98006 19879-30-2 20mg QQ客服:1148253675
    甲基补骨脂黄酮 CFN98006 19879-30-2 50mg QQ客服:1148253675
    甲基补骨脂黄酮 CFN98006 19879-30-2 100mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Mendel University in Brno (Czech Republic)
  • Ateneo de Manila University (Philippines)
  • Osmania University (India)
  • The Institute of Cancer Research (United Kingdom)
  • Lodz University of Technology (Poland)
  • FORTH-IMBB (Greece)
  • Universidad Veracuzana (Mexico)
  • Cornell University (USA)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Rio de Janeiro State University (Brazil)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Siksha O Anusandhan University (India)
  • CSIRO - Agriculture Flagship (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nat Prod Sci.2014, 20(3):182-190
  • Anticancer Res.2014, 34(7):3505-9
  • Int J Mol Sci.2015, 16(8):18396-411
  • J Pharm Biomed Anal2016, 118:183-194
  • BMC Complement Altern Med.2016, 16:213
  • Molecules.2016, 21(6)
  • Nat Prod Sci.2016, 22(2)
  • Semyung University2017, 149407
  • J Ethnopharmacol.2017, 206:327-336
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • Lab Chip.2018, 18(6):971-978
  • Exp Parasitol.2018, 194:67-78
  • Front Pharmacol.2018, 9:756
  • Wageningen University & Research2018, January 2018
  • Nat Commun.2019, 10(1):5169
  • World J Mens Health.2019, 10.5534
  • Nutr Metab (Lond).2019, 16:31
  • Chem Biol Interact.2019, 315:108910
  • Oncol Rep.2019, 41(4):2453-2463
  • Phytomedicine.2019, 55:229-237
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Food and Chemical Toxicology2020, 111221
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • ...
  • 生物活性
    Description: Bavachinin is a novel natural pan-PPAR agonist , it shows stronger activities with PPAR-γ than with PPAR-α and PPAR-β/δ (EC50 = 0.74 μmol/l, 4.00 μmol/l and 8.07 μmol/l in 293T cells, respectively). Bavachinin possesses anti-asthma, anti-angiogenic , anti-inflammatory, antipyretic and analgesic properties, it also exhibits glucose-lowering properties without inducing weight gain and hepatotoxicity.
    Targets: PPAR | HIF | VEGFR | GLUT | Immunology & Inflammation related
    In vitro:
    Indian J. Exp. Biol., 1978, 16(11):1216-7.
    Antiinflamatory, antipyretic & analgesic properties of bavachinin-a flavanone isolated from seeds of Psoralea corylifolia Linn. (Babchi).[Pubmed: 312274]
    Antiinflamatory, antipyretic & analgesic properties of bavachinin-a flavanone isolated from seeds of Psoralea corylifolia Linn. (Babchi).
    In vivo:
    Eur J Pharmacol. 2012 Sep 15;691(1-3):28-37.
    Anti-angiogenic and anti-tumor activity of Bavachinin by targeting hypoxia-inducible factor-1α.[Pubmed: 22760073]
    Hypoxia-inducible factor-1 (HIF-1) consists of two subunits, the HIF-1β, which is constitutively expressed, and HIF-1α, which is oxygen-responsive. HIF-1α is over-expressed in response to hypoxia, increasing transcriptional activity linked to tumor progression, angiogenesis, metastasis, and invasion. This study aimed to demonstrate that the natural compound, Bavachinin, has potent anti-angiogenic activity in vitro and in vivo.
    METHODS AND RESULTS:
    Bavachinin inhibited increases in HIF-1α activity in human KB carcinoma (HeLa cell derivative) and human HOS osteosarcoma cells under hypoxia in a concentration-dependent manner, probably by enhancing the interaction between von Hippel-Lindau (VHL) and HIF-1α. Furthermore, Bavachinin decreased transcription of genes associated with angiogenesis and energy metabolism that are regulated by HIF-1, such as vascular endothelial growth factors (VEGF), Glut 1 and Hexokinase 2. Bavachinin also inhibited tube formation in human umbilical vein endothelial cells (HUVECs) as well as in vitro migration of KB cells. In vivo studies showed that injecting Bavachinin thrice weekly for four weeks significantly reduced tumor volume and CD31 expression in nude mice with KB xenografts.
    CONCLUSIONS:
    These data indicate that Bavachinin could be used as a therapeutic agent for inhibiting tumor angiogenesis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9551 mL 14.7754 mL 29.5508 mL 59.1017 mL 73.8771 mL
    5 mM 0.591 mL 2.9551 mL 5.9102 mL 11.8203 mL 14.7754 mL
    10 mM 0.2955 mL 1.4775 mL 2.9551 mL 5.9102 mL 7.3877 mL
    50 mM 0.0591 mL 0.2955 mL 0.591 mL 1.182 mL 1.4775 mL
    100 mM 0.0296 mL 0.1478 mL 0.2955 mL 0.591 mL 0.7388 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5-Dehydroxyparatocarpin K; 5-Dehydroxyparatocarpin K CFN96117 124858-37-3 C20H18O4 = 322.4 5mg QQ客服:215959384
    异补骨脂黄酮; Isobavachin CFN98400 31524-62-6 C20H20O4 = 324.4 20mg QQ客服:1148253675
    光甘草宁; Glabranin CFN98659 41983-91-9 C20H20O4 = 324.4 5mg QQ客服:1148253675
    二氢倒卵灰毛豆素; Dihydroobovatin CFN96075 104055-79-0 C20H20O4 = 324.4 5mg QQ客服:215959384
    二氢柠檬黄烷酮 ; Dihydrocitflavanone CFN96562 70897-14-2 C20H20O5 = 340.38 5mg QQ客服:1148253675
    6-异戊二烯基柚皮素; 6-Prenylnaringenin CFN92017 68236-13-5 C20H20O5 = 340.4 5mg QQ客服:1148253675
    6-异戊烯基樱花亭; 6-Prenylsakuranetin CFN92901 261776-61-8 C21H22O5 = 354.40 5mg QQ客服:2159513211
    8-异戊烯基柚皮素; 8-Prenylnaringenin CFN92016 53846-50-7 C20H20O5 = 340.4 10mg QQ客服:2159513211
    异黄腐醇; Isoxanthohumol CFN90768 70872-29-6 C21H22O5 = 354.4 10mg QQ客服:3257982914
    6-香叶草基柚皮素; 6-Geranylnaringenin CFN92019 97126-57-3 C25H28O5 = 408.5 5mg QQ客服:3257982914

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