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  • 8-异戊烯基柚皮素

    8-Prenylnaringenin

    8-异戊烯基柚皮素
    产品编号 CFN92016
    CAS编号 53846-50-7
    分子式 = 分子量 C20H20O5 = 340.4
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Flavonoids
    植物来源 The herbs of Humulus lupulus.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    8-异戊烯基柚皮素 CFN92016 53846-50-7 1mg QQ客服:1413575084
    8-异戊烯基柚皮素 CFN92016 53846-50-7 5mg QQ客服:1413575084
    8-异戊烯基柚皮素 CFN92016 53846-50-7 10mg QQ客服:1413575084
    8-异戊烯基柚皮素 CFN92016 53846-50-7 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • University of East Anglia (United Kingdom)
  • Yale University (USA)
  • Griffith University (Australia)
  • University of Bordeaux (France)
  • Kamphaengphet Rajabhat University (Thailand)
  • University of Illinois (USA)
  • Univerzita Karlova v Praze (Czech Republic)
  • Michigan State University (USA)
  • Chulalongkorn University (Thailand)
  • Kazusa DNA Research Institute (Japan)
  • Rio de Janeiro State University (Brazil)
  • Mahatma Gandhi University (India)
  • University of Helsinki (Finland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • China Pharmacy2015, 26(27)
  • BMC Complement Altern Med.2016, 16:213
  • Chemistr of plant2016, 2016021195
  • Kor. J. Pharmacogn.2016, 47(1):62-72
  • Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36
  • Int J Mol Sci.2017, 18(5)
  • J Ethnopharmacol.2017, 209:305-316
  • Molecules.2017, 22(2)
  • Korean J. of Horticultural Sci. & Tech. 2017, 793-804
  • Int J Biol Macromol.2018, 112:1093-1103
  • Yakugaku Zasshi.2018, 138(4):571-579
  • BMC Plant Biol.2018, 18(1):122
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • BMC Complement Altern Med.2019, 19(1):367
  • Spectrochim Acta A2019, 210:372-380
  • Molecules.2019, 24(22):E4022
  • The Korea Journal of Herbology2019, 34(2):25-32
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • Academic J of Second Military Medical University2019, 40(1)
  • J Sep Sci.2019, 42(21):3352-3362
  • Phytomedicine.2019, 57:95-104
  • Plos One.2019, 15(2):e0220084
  • J Pharmaceut Biomed2020, 178:112894
  • ...
  • 生物活性
    Description: 8-Prenylnaringenin is a phytoestrogen with high estrogenic activity, it shows more potent effects on promoting osteoblastic bone formation and inhibiting osteoclastic bone resorption by ERα instead of ERβ than the two classic phytoestrogens: genistein and daidzein. 8-Prenylnaringenin at all assayed doses (0.001-20 µM) presumably improves mitochondrial function, whereas a high dose of XN (5 µM) worsens the functionality of this organelle.
    Targets: Estrogen receptor | NF-kB | ROS | Progestogen receptor
    In vitro:
    Strahlenther Onkol. 2015 May;191(5):429-36.
    8-prenylnaringenin and tamoxifen inhibit the shedding of irradiated epithelial cells and increase the latency period of radiation-induced oral mucositis : cell culture and murine model.[Pubmed: 25432325]
    The major component in the pathogenesis of oral radiation-induced mucositis is progressive epithelial hypoplasia and eventual ulceration. Irradiation inhibits cell proliferation, while cell loss at the surface continues. We conceived to slow down this desquamation by increasing intercellular adhesion, regulated by the E-cadherin/catenin complex. We investigated if 8-prenylnaringenin (8-PN) or tamoxifen (TAM) decrease the shedding of irradiated human buccal epithelial cells in vitro and thus delay the ulcerative phase of radiation-induced mucositis in vivo.
    METHODS AND RESULTS:
    In vitro, aggregates of buccal epithelial cells were irradiated and cultured in suspension for 11 days. 8-PN or TAM were investigated regarding their effect on cell shedding. In vivo, the lower tongue surface of mice was irradiated with graded single doses of 25 kV X-rays. The incidence, latency, and duration of the resulting mucosal ulcerations were analyzed after topical treatment with 8-PN, TAM or solvent. 8-PN or TAM prevented the volume reduction of the irradiated cell aggregates during the incubation period. This was the result of a higher residual cell number in the treated versus the untreated irradiated aggregates. In vivo, topical treatment with 8-PN or TAM significantly increased the latency of mucositis from 10.9 to 12.1 and 12.4 days respectively, while the ulcer incidence was unchanged.
    CONCLUSIONS:
    8-PN and TAM prevent volume reduction of irradiated cell aggregates in suspension culture. In the tongues of mice, these compounds increase the latency period. This suggests a role for these compounds for the amelioration of radiation-induced mucositis in the treatment of head and neck tumors.
    Planta Med. 2015 Mar;81(4):305-11.
    Neurodifferentiating potential of 8-prenylnaringenin and related compounds in neural precursor cells and correlation with estrogen-like activity.[Pubmed: 25714726]
    Neurodegenerative diseases are an increasing burden for our ageing societies; there is an as yet unmet need for the development of effective therapies. Neurogenesis, i.e., the generation of new neurons in the adult brain from neural stem cells, has received increasing attention since it offers the potential for endogenous brain repair and functional regeneration. Adult neurogenesis is partially under the control of sex hormones such as estradiol, and boosting neurogenesis with estradiol in animals correlates with cognitive improvement. 8-Prenylnaringenin imitates as highly potent phytoestrogen the effects of estradiol.
    METHODS AND RESULTS:
    Here, we studied the potential of 8-prenylnaringenin, 6-prenylnaringenin, and related compounds on differentiation induction in vitro using neural precursor cells transiently transfected with a doublecortin promoter luciferase construct, which was recently shown to indicate neuronal fate and differentiation. The flavanones 8-prenylnaringenin and 6-prenylnaringenin showed slight activity in this assay but significant activity by immunostaining. Although the estrogen-like activities of 8-prenylnaringenin and 6-prenylnaringenin are very different, the activity in differentiation induction is similar. Interestingly, also some prenylflavonoids with extended prenyl groups, e.g., a geranyl group, showed increased differentiation activity, while estrogen-like activity is decreased.
    CONCLUSIONS:
    This allows the conclusion that estrogen-like activity of prenylflavanones does not correlate directly with the activity of differentiation induction in neural precursor cells.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9377 mL 14.6886 mL 29.3772 mL 58.7544 mL 73.443 mL
    5 mM 0.5875 mL 2.9377 mL 5.8754 mL 11.7509 mL 14.6886 mL
    10 mM 0.2938 mL 1.4689 mL 2.9377 mL 5.8754 mL 7.3443 mL
    50 mM 0.0588 mL 0.2938 mL 0.5875 mL 1.1751 mL 1.4689 mL
    100 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.5875 mL 0.7344 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6-异戊二烯基柚皮素; 6-Prenylnaringenin CFN92017 68236-13-5 C20H20O5 = 340.4 5mg QQ客服:2932563308
    6-异戊烯基樱花亭; 6-Prenylsakuranetin CFN92901 261776-61-8 C21H22O5 = 354.40 5mg QQ客服:2932563308
    8-异戊烯基柚皮素; 8-Prenylnaringenin CFN92016 53846-50-7 C20H20O5 = 340.4 10mg QQ客服:1148253675
    异黄腐醇; Isoxanthohumol CFN90768 70872-29-6 C21H22O5 = 354.4 10mg QQ客服:3257982914
    6-香叶草基柚皮素; 6-Geranylnaringenin CFN92019 97126-57-3 C25H28O5 = 408.5 5mg QQ客服:215959384
    6,8-二异戊二烯基柚皮素; 6,8-Diprenylnaringenin CFN92018 68236-11-3 C25H28O5 = 408.5 5mg QQ客服:2932563308
    苦参醇A; Kushenol A CFN92000 99217-63-7 C25H28O5 = 408.5 5mg QQ客服:2932563308
    甲基补骨脂黄酮; Bavachinin CFN98006 19879-30-2 C21H22O4 = 338.4 20mg QQ客服:2159513211
    5-Dehydroxyparatocarpin K; 5-Dehydroxyparatocarpin K CFN96117 124858-37-3 C20H18O4 = 322.4 5mg QQ客服:215959384
    异补骨脂黄酮; Isobavachin CFN98400 31524-62-6 C20H20O4 = 324.4 20mg QQ客服:1148253675

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