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  • 异补骨脂黄酮

    Isobavachin

    异补骨脂黄酮
    产品编号 CFN98400
    CAS编号 31524-62-6
    分子式 = 分子量 C20H20O4 = 324.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The fruits of Psoralea corylifolia L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    异补骨脂黄酮 CFN98400 31524-62-6 10mg QQ客服:2159513211
    异补骨脂黄酮 CFN98400 31524-62-6 20mg QQ客服:2159513211
    异补骨脂黄酮 CFN98400 31524-62-6 50mg QQ客服:2159513211
    异补骨脂黄酮 CFN98400 31524-62-6 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Toulouse (France)
  • University of Minnesota (USA)
  • National Cancer Center Research Institute (Japan)
  • University of Oslo (Norway)
  • Periyar University (India)
  • University of Amsterdam (Netherlands)
  • National Chung Hsing University (Taiwan)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Kyoto University (Japan)
  • University of Medicine and Pharmacy (Romania)
  • Mahidol University (Thailand)
  • Chang Gung University (Taiwan)
  • Wroclaw Medical University (Poland)
  • Universit?t Basel (Switzerland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacogn Mag.2015, 11(43):562-6
  • Evid Based Complement Alternat Med.2015, 2015:165457
  • Chemistry of Plant Materials.2016, 33-46
  • Biochem Systematics and Ecology2017, 11-18
  • Free Radic Biol Med.2017, 112:191-199
  • Biochem Biophys Res Commun.2017, 482(4):1095-1101
  • J Nat Med.2017, 71(2):457-462
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • Biochem Biophys Res Commun.2018, 505(1):194-200
  • The Japan Society for Analytical Chemistry2018, 67(4):201-206
  • Sci Rep.2018, 8:9267
  • Eur J Pharmacol.2018, 832:96-103
  • Cancer Manag Res.2019, 11:483-500
  • Int J Biol Macromol.2019, 126:653-661
  • International J of Green Pharmacy2019, 13(3)
  • J of Physics Conference Series2019, 1349(1)
  • Nutr Metab (Lond).2019, 16:31
  • BMC Complement Altern Med.2019, 19(1):367
  • BMC Microbiol.2019, 19(1):78
  • Anal Biochem.2019, 569:10-15
  • Food Res Int.2020, 128:108778
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • Antioxidants (Basel).2020, 9(2):E99
  • ...
  • 生物活性
    Description: Isobavachin can stimulate osteoblasts proliferation and differentiation; it also can facilitate mouse embryonic stem cells differentiating into neuronal cells, the mechanism involved protein prenylation and, subsequently, phos-ERK activation and the phos-p38 off pathway. Isobavachin possesses estrogen-like activity in MCF-7/BOS cells, it can significantly stimulate the proliferation of MCF-7/BOS cells in a dose-dependent manner. Isobavachin has cytotoxic effects on H4IIE hepatoma and metabolically poorly active C6 glioma cells.
    Targets: ERK | p38MAPK | Caspase
    In vitro:
    Acta Pharmacol Sin. 2011 Apr;32(4):425-32.
    Promoting effects of isobavachin on neurogenesis of mouse embryonic stem cells were associated with protein prenylation.[Pubmed: 21441946]
    Some small molecules can induce mouse embryonic stem (ES) cells to differentiate into neuronal cells. Here, we explored the effect of Isobavachin (IBA), a compound with a prenyl group at position 8 of ring A, on promoting neuronal differentiation and the potential role of its protein prenylation.
    METHODS AND RESULTS:
    The hanging drop method was employed for embryonic body (EB) formation to mimic embryo development in vivo. The EBs were treated with Isobavachin at a final concentration of 10(-7) mol/L from EB stage (d 4) to d 8+10. Geranylgeranyltransferase I inhibitor GGTI-298 was subsequently used to disrupt protein prenylation. Neuronal subtypes, including neurons and astrocytes, were observed by fluorescence microscopy. Gene and protein expression levels were detected using RT-PCR and Western blot analysis, respectively. With Isobavachin treatment, nestin was highly expressed in the neural progenitors generated from EBs (d 4, d 8+0). EBs then further differentiated into neurons (marked by β-tubulin III) and astrocytes (marked by GFAP), which were both up-regulated in a time-dependent manner on d 8+5 and d 8+10. Co-treatment with GGTI-298 selectively abolished the Isobavachin-induced neuronal differentiation. Moreover, in the MAPK pathway, p38 and JNK phosphorylation were down-regulated, while ERK phosphorylation was up-regulated after Isobavachin treatment at different neuronal differentiation passages.
    CONCLUSIONS:
    Isobavachin can facilitate mouse ES cells differentiating into neuronal cells. The mechanism involved protein prenylation and, subsequently, phos-ERK activation and the phos-p38 off pathway.
    Food Chem Toxicol. 2007 Jan;45(1):119-24.
    Prenylation enhances cytotoxicity of apigenin and liquiritigenin in rat H4IIE hepatoma and C6 glioma cells.[Pubmed: 17045382 ]
    Antioxidative as well as cytotoxic effects of the prenylated flavonoids licoflavone C (8-prenylapigenin) and isobavachin (8-prenylliquiritigenin) were investigated in comparison to the corresponding non-prenylated flavonoids (apigenin, liquiritigenin) and vitexin (apigenin-C8-glucoside) using metabolically active H4IIE hepatoma and metabolically poorly active C6 glioma cells.
    METHODS AND RESULTS:
    None of the substances showed radical scavenging activities in the 2,2-diphenyl-1-picrylhydrazyl (DPPH)-assay nor were they effective in protection against H2O2-induced intracellular 2',7'-dichlorodihydrofluorescein (H2DCF) oxidation (fluorescent probe for oxidative stress) in H4IIE and C6 cells. When the intrinsic effects of the substances were investigated, licoflavone C and isobavachin exerted a pronounced toxicity in both H4IIE (IC50 values of 42+/-5 and 96+/-19 micromol/L) and C6 cells (IC50 values of 37+/-6 and 69+/-3 micromol/L) while the non-prenylated analogues as well as the glycosylated derivate vitexin showed almost no cytotoxic effect up to 250 micromol/L. In H4IIE cells the induction of apoptotic cell death by licoflavone C and icobavachin was detected as an activation of caspase 3/7 (6- and 3.3-fold, respectively).
    CONCLUSIONS:
    Based on these experiments we suggest that C8-prenylation of a flavonoid enhances the cytotoxicity inducing an apoptotic cell death in H4IIE cells without affecting antioxidative properties.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0826 mL 15.4131 mL 30.8261 mL 61.6523 mL 77.0654 mL
    5 mM 0.6165 mL 3.0826 mL 6.1652 mL 12.3305 mL 15.4131 mL
    10 mM 0.3083 mL 1.5413 mL 3.0826 mL 6.1652 mL 7.7065 mL
    50 mM 0.0617 mL 0.3083 mL 0.6165 mL 1.233 mL 1.5413 mL
    100 mM 0.0308 mL 0.1541 mL 0.3083 mL 0.6165 mL 0.7707 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    8-异戊烯基柚皮素; 8-Prenylnaringenin CFN92016 53846-50-7 C20H20O5 = 340.4 10mg QQ客服:215959384
    异黄腐醇; Isoxanthohumol CFN90768 70872-29-6 C21H22O5 = 354.4 10mg QQ客服:1413575084
    6-香叶草基柚皮素; 6-Geranylnaringenin CFN92019 97126-57-3 C25H28O5 = 408.5 5mg QQ客服:2932563308
    6,8-二异戊二烯基柚皮素; 6,8-Diprenylnaringenin CFN92018 68236-11-3 C25H28O5 = 408.5 5mg QQ客服:2159513211
    苦参醇A; Kushenol A CFN92000 99217-63-7 C25H28O5 = 408.5 5mg QQ客服:2932563308
    甲基补骨脂黄酮; Bavachinin CFN98006 19879-30-2 C21H22O4 = 338.4 20mg QQ客服:2159513211
    5-Dehydroxyparatocarpin K; 5-Dehydroxyparatocarpin K CFN96117 124858-37-3 C20H18O4 = 322.4 5mg QQ客服:3257982914
    异补骨脂黄酮; Isobavachin CFN98400 31524-62-6 C20H20O4 = 324.4 20mg QQ客服:215959384
    光甘草宁; Glabranin CFN98659 41983-91-9 C20H20O4 = 324.4 5mg QQ客服:215959384
    二氢倒卵灰毛豆素; Dihydroobovatin CFN96075 104055-79-0 C20H20O4 = 324.4 5mg QQ客服:1148253675

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