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    23-O-Acetylshengmanol 3-O-beta-D-xyloside

    23-O-Acetylshengmanol 3-O-beta-D-xyloside

    23-O-Acetylshengmanol 3-O-beta-D-xyloside
    产品编号 CFN92970
    CAS编号 62498-88-8
    分子式 = 分子量 C37H58O10 = 662.85
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Curculigo orchioides
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    23-O-Acetylshengmanol 3-O-beta-D-xyloside CFN92970 62498-88-8 1mg QQ客服:1413575084
    23-O-Acetylshengmanol 3-O-beta-D-xyloside CFN92970 62498-88-8 5mg QQ客服:1413575084
    23-O-Acetylshengmanol 3-O-beta-D-xyloside CFN92970 62498-88-8 10mg QQ客服:1413575084
    23-O-Acetylshengmanol 3-O-beta-D-xyloside CFN92970 62498-88-8 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

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    doi: 10.1021/acsnano.7b08969.
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    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

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  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • China Pharmacy2015, 26(27)
  • Tumour Biol.2015, 36(9):7027-34
  • Nat Plants.2016, 3:16205
  • Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36
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  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
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  • Front Pharmacol.2018, 9:756
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  • Int J Mol Sci.2019, 20(16):E4015
  • Chemistry of Plant Materials.2019, 215-222
  • Molecules.2019, 24(10):E1930
  • Molecules.2019, 24(6):E1155
  • Pharmaceutical Chemistry Journal2019, 52(12):986-991
  • Dent Mater J.2020, 39(4):690-695
  • Appl. Sci.2020, 10(20), 7323.
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  • Front Immunol. 2020, 11:62.
  • BMC Complement Med Ther. 2020, 20(1):91.
  • Horticulturae2020, 6(4),76.
  • Phytochemistry.2021, 181:112539.
  • J Ethnopharmacol.2021, 267:113615.
  • ...
  • 生物活性
    Description: 23-O-Actylshengmanol-3-xyloside selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.
    Targets: TNF-α | PPAR-γ | ERK | PI3K | PKC
    In vitro:
    Journal of Ethnopharmacology, 2011, 133(2):0-344.
    Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae Rhizome inhibit TNF-α-induced VCAM-1 expression in human endothelial cells: Involvement of PPAR-γ upregulation and PI3K, ERK1/2, and PKC signal pathways.[Reference: WebLink]
    The methanol extract of Cimicifugae Rhizome has been traditionally used in various disorders including inflammation.
    METHODS AND RESULTS:
    The aim of the study is to explore whether anti-inflammatory action of 3 active compounds, two triterpenoid glycosides (cimiside E, 23-O-actylshengmanol-3-xyloside(23-O-Acetylshengmanol 3-O-beta-D-xyloside)) and one furanocoumarin (isoimperatorin), isolated from Cimicifugae Rhizome is related with peroxisome proliferator-activated receptor-γ (PPAR-γ) expression in human umbilical endothelial cell line, EA.hy926 cells. Cell viability and production of reactive oxygen species were performed. In addition, adhesion of monocyte into endothelial cells and western blot for expression of adhesion molecules and signal proteins were investigated in tumor necrosis factor-α (TNF-α)-activated cells. Pretreatment of test compounds significantly reduced reactive oxygen species (ROS) production and expression of vascular cell adhesion molecule-1 (VCAM-1), but not intercellular cell adhesion molecule-1 (ICAM-1). Three compounds all dose-dependently increased not only PPAR-γ expression in EA.hy926 cells but inhibited TNF-α-induced phosphorylation of Akt, extracellular-signal-regulated kinase (ERK) and protein kinase C (PKC) with different specificity. Finally, they prevented TNF-α-induced adhesion of U937 monocytic cells to EA.hy926 cells.
    CONCLUSIONS:
    The present results show that cimiside E, 23-O-actylshengmanol-3-xyloside, isoimperatorin isolated from Cimicifugae Rhizome selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5086 mL 7.5432 mL 15.0864 mL 30.1727 mL 37.7159 mL
    5 mM 0.3017 mL 1.5086 mL 3.0173 mL 6.0345 mL 7.5432 mL
    10 mM 0.1509 mL 0.7543 mL 1.5086 mL 3.0173 mL 3.7716 mL
    50 mM 0.0302 mL 0.1509 mL 0.3017 mL 0.6035 mL 0.7543 mL
    100 mM 0.0151 mL 0.0754 mL 0.1509 mL 0.3017 mL 0.3772 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (3beta,22E)-9,19-环羊毛甾-22-烯-3,25-二醇; Cycloart-22-ene-3,25-diol CFN97555 97456-49-0 C30H50O2 = 442.7 5mg QQ客服:1457312923
    环羊毛甾-24-烯-1alpha,2alpha,3beta-三醇; Cycloart-24-ene-1alpha,2alpha,3beta-triol CFN91991 942407-97-8 C30H50O3 = 458.72 5mg QQ客服:1413575084
    29-去甲羊毛甾-8,24-二烯-1alpha,2alpha,3beta-三醇; 29-Norlanosta-8,24-diene-1alpha,2alpha,3beta-triol CFN91990 119765-92-3 C29H48O3 = 444.69 5mg QQ客服:1457312923
    25-羟基环木菠萝-23-烯-3-酮; 25-Hydroxycycloart-23-en-3-one CFN99613 148044-47-7 C30H48O2 = 440.7 5mg QQ客服:2159513211
    29-去甲环安坦-23-烯-3,25-二醇; 29-Norcycloart-23-ene-3,25-diol CFN97849 115040-04-5 C29H48O2 = 428.7 5mg QQ客服:1413575084
    环安坦-3,24,25-三醇; Cycloartane-3,24,25-triol CFN98972 57576-29-1 C30H52O3 = 460.7 5mg QQ客服:3257982914
    (24S)-环安坦-3,24,25-三醇24,25-缩丙酮; (24S)-Cycloartane-3,24,25-triol 24,25-acetonide CFN98973 57576-31-5 C33H56O3 = 500.8 5mg QQ客服:2159513211
    24,25-二羟基环木菠萝烷-3-酮; 24,25-Dihydroxycycloartan-3-one CFN99653 155060-48-3 C30H50O3 = 458.7 5mg QQ客服:1413575084
    栀子花乙酸; Gardenolic acid B CFN96838 108864-53-5 C30H46O5 = 486.69 5mg QQ客服:2932563308
    黑升麻苷H-2; Cimicifugoside H2 CFN92972 161097-77-4 C35H54O10 = 634.8 5mg QQ客服:2159513211

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