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  • 1,5-二咖啡酰奎宁酸; 洋蓟素

    1,5-Dicaffeoylquinic acid

    1,5-二咖啡酰奎宁酸; 洋蓟素
    产品编号 CFN99123
    CAS编号 30964-13-7
    分子式 = 分子量 C25H24O12 = 516.45
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Phenolic Acids
    植物来源 The herbs of Lonicera japonica Thunb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    1,5-二咖啡酰奎宁酸; 洋蓟素 CFN99123 30964-13-7 10mg QQ客服:2159513211
    1,5-二咖啡酰奎宁酸; 洋蓟素 CFN99123 30964-13-7 20mg QQ客服:2159513211
    1,5-二咖啡酰奎宁酸; 洋蓟素 CFN99123 30964-13-7 50mg QQ客服:2159513211
    1,5-二咖啡酰奎宁酸; 洋蓟素 CFN99123 30964-13-7 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Malaya (Malaysia)
  • University of Hawaii Cancer Center (USA)
  • Monash University Malaysia (Malaysia)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Lund University (Sweden)
  • University of Vigo (Spain)
  • University of Helsinki (Finland)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • University of Mysore (India)
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  • Universidad Industrial de Santander (Colombia)
  • Institute of Chinese Materia Medica (China)
  • University of Cincinnati (USA)
  • Calcutta University (India)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Med.2015, 35(5):1237-45
  • Food Chem.2016, 191:81-90
  • J Pharm Anal.2016, 6(6):363-373
  • Onco Targets Ther.2017, 10:3467-3474
  • African J. Agricultural Research 2017, 12(13):1164-1168
  • Phytomedicine.2017, 24:77-86
  • Phytochemistry Letters2017, 449-455
  • Korean J of Food Science&Technology 2017, 49(2):146-150
  • J Sci Food Agric.2017, 97(5):1656-1662
  • Food Res Int.2018, 106:909-919
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Int J Mol Sci.2018, 19(2)
  • Molecules.2018, 23(7):E1817
  • Oncology Letters2018, 4690-4696
  • Sci Rep.2018, 8(1):12970
  • Virulence.2018, 9(1):588-603
  • Pharmacognosy Journal2019, 11,6:1235-1241
  • J Pharm Biomed Anal.2019, 164:119-127
  • Cardiovasc Toxicol.2019, 19(4):297-305
  • Molecules.2019, 24(4):E744
  • J Sep Sci.2019, 42(21):3352-3362
  • Food and Fermentation Industries2019, 45(7):45-51
  • J Sep Sci.2020, 201901140
  • ...
  • 生物活性
    Description: 1,5-Dicaffeoylquinic acid has neuroprotective, and antioxidant effects, it can prevent Aβ(42)-induced neurotoxicity through the activation of PI3K/Akt followed by the stimulation of Trk A, then the inhibition of GSK3β as well as the modulation of Bcl-2/Bax. 1,5-Dicaffeoylquinic acid has protective effects against MPP~+ induces neurotoxicity of PC12 Cells, it (50 umol/L) pretreatment can inhibit the MPP+-induced up-regulation of the expression of α-synuclein mRNA and protein.
    Targets: ERK | Trk receptor | Bcl-2/Bax | Beta Amyloid | PI3K | GSK-3 | ROS | Nrf2
    In vitro:
    Zhongguo Zhong Yao Za Zhi. 2014 Jun;39(12):2275-80.
    Regulation of syringin, chlorogenic acid and 1,5-dicaffeoylquinic acid biosynthesis in cell suspension cultures of Saussurea involucrata.[Pubmed: 25244758]
    Syringin, chlorogenic acid and 1,5-dicaffeoylquinic acid are three main bioactive ingredients in herbs of Saussurea involucrata with various pharmacological properties, while their contents are very low.
    METHODS AND RESULTS:
    In this study, the biosynthesis of syringin, chlorogenic acid and 1,5-dicaffeoylquinic acid in the cell suspension cultures of S. involucrata were regulated by feeding carbon sources and precursors, which resulted in a great increase of the contents and yields of the above three bioactive ingredients. After 16 days of fermentation, the yields of syringin, chlorogenic acid and 1,5-dicaffeoylquinic acid reached 339.0, 225.3, 512.7 mg x L(-1), respectively. Meanwhile, their contents increased up to 67.9, 1.9, 10.6 times of wild medicinal material, respectively.
    CONCLUSIONS:
    The results provided a solid basis for further studies on application of cell suspension cultures of S. involucrata for large-scale production of bioactive compounds syringin, chlorogenic acid and 1,5-dicaffeoylquinic acid.
    Organic. Chem., 1999, 72.
    1,5-Dicaffeoylquinic acid, an antioxidant component of Cynara cardunculus leaves[Reference: WebLink]

    METHODS AND RESULTS:
    This study describes the isolation, identification and some antioxidant properties of 1,5-Dicaffeoylquinic acid. This compound was isolated from a methanolic extract of Cynara cardunculus leaves. The isolation was based on a selective extraction of 1,5-Dicaffeoylquinic acid with diethylether from a weak acidic water-methanolic solution and on column chromatography. The compound structure was determined by 1D and 2D H-NMR spectroscopy. Inhibition of hemolysis induced by hydrogen peroxide and the anti-radical effect of both 1,5-Dicaffeoylquinic acid and cynarin (1,3-dicaffeoylquinic acid) were studied. Cynarin was formed from 1,5-Dicaffeoylquinic acid by trans-esterification during solvent extraction.
    CONCLUSIONS:
    The antioxidant activity of dicaffeoylquinic acids in both systems was found to be stronger than that of ascorbic acid.
    Brain Res. 2010 Aug 6;1347:142-8.
    1, 5-Dicaffeoylquinic acid-mediated glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytes.[Pubmed: 20513363 ]
    Oxidative stress plays an important role in pathological processes of cerebral ischemia followed by reperfusion.
    METHODS AND RESULTS:
    The effect of 1,5-Dicaffeoylquinic acid (1, 5-diCQA) on primary culture rat cortical astrocytes induced by oxygen and glucose deprivation (OGD)/reperfusion was evaluated in this study. Appropriate concentration of 1, 5-diCQA pretreatment significantly suppressed cell death, reduced the production of reactive oxygen species, prevented glutathione (GSH) depletion, increased the activity of glutamate-cysteine ligase (GCL), and triggered Nrf2 nuclear translocation in astrocytes induced by 4h of OGD and 20 h of reperfusion. Interestingly, these protective effects were greatly attenuated in Nrf2 siRNA-transfected cells.
    CONCLUSIONS:
    We conclude that 1, 5-diCQA has antioxidant signaling properties that upregulate GSH synthesis by stimulating the Nrf2 pathway in astrocytes and protects them from cell death in an in vitro model of ischemia/reperfusion.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9363 mL 9.6815 mL 19.363 mL 38.7259 mL 48.4074 mL
    5 mM 0.3873 mL 1.9363 mL 3.8726 mL 7.7452 mL 9.6815 mL
    10 mM 0.1936 mL 0.9681 mL 1.9363 mL 3.8726 mL 4.8407 mL
    50 mM 0.0387 mL 0.1936 mL 0.3873 mL 0.7745 mL 0.9681 mL
    100 mM 0.0194 mL 0.0968 mL 0.1936 mL 0.3873 mL 0.4841 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4,5-O-二咖啡酰基奎宁酸甲酯; 4,5-Di-O-caffeoylquinic acid methyl ester CFN90858 188742-80-5 C26H26O12 = 530.5 5mg QQ客服:2159513211
    3,4,5-三咖啡酰奎宁酸; 3,4,5-Tricaffeoylquinic acid CFN90238 86632-03-3 C34H30O15 = 678.59 5mg QQ客服:215959384
    单咖啡酰洒石酸; Caftaric acid CFN00384 67879-58-7 C13H12O9 = 312.2 10mg QQ客服:2932563308
    菊苣酸; Chicoric acid CFN99725 70831-56-0 C22H18O12 = 474.37 20mg QQ客服:3257982914
    1,5-二咖啡酰奎宁酸; 洋蓟素; 1,5-Dicaffeoylquinic acid CFN99123 30964-13-7 C25H24O12 = 516.45 20mg QQ客服:3257982914
    异绿原酸B; Isochlorogenic acid B CFN99119 14534-61-3 C25H24O12 = 516.45 20mg QQ客服:1148253675
    3,4-二咖啡酰奎宁酸乙酯; Ethyl 3,4-dicaffeoylquinate CFN91970 143051-73-4 C27H28O12 = 544.50 5mg QQ客服:3257982914
    3,4-O-二咖啡酰基奎宁酸甲酯; 3,4-Di-O-caffeoylquinic acid methyl ester CFN90856 114637-83-1 C26H26O12 = 530.5 5mg QQ客服:3257982914
    异绿原酸A; Isochlorogenic acid A CFN99118 2450-53-5 C25H24O12 = 516.45 20mg QQ客服:2159513211
    3,5-二咖啡酰-表-奎宁酸; 3,5-Dicaffeoyl-epi-quinic acid CFN91944 879305-14-3 C25H24O12 = 516.45 5mg QQ客服:2932563308

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