
反式-4-羟基-2-壬烯酸
trans-4-Hydroxy-2-nonenoic acid
|
产品编号 |
CFN92983 |
CAS编号 |
95087-42-6 |
分子式 = 分子量 |
C9H16O3 = 172.22 |
产品纯度 |
>=98% |
物理属性 |
Powder |
化合物类型 |
Miscellaneous |
植物来源 |
The herbs of Sarcandra glabra |
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
反式-4-羟基-2-壬烯酸 |
CFN92983 |
95087-42-6 |
1mg |
QQ客服:2056216494 |
反式-4-羟基-2-壬烯酸 |
CFN92983 |
95087-42-6 |
5mg |
QQ客服:2056216494 |
反式-4-羟基-2-壬烯酸 |
CFN92983 |
95087-42-6 |
10mg |
QQ客服:2056216494 |
反式-4-羟基-2-壬烯酸 |
CFN92983 |
95087-42-6 |
20mg |
QQ客服:2056216494 |
1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。
2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。
3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
订购流程
1. 在线订购
请联系我们QQ客服
2. 电话订购
请拨打电话:
027-84237683 或 027-84237783
3. 邮件或传真订购
发送电子邮件到: manager@chemfaces.com 或
发送传真到:027-84254680
提供订购信息
为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
1. 产品编号(CAS No.或产品名称)
2. 发货地址
3. 联系方法 (联系人,电话)
4. 开票抬头 (如果需要发票的客户)
5. 发票地址(发货地址与发票地址不同)
发货时间
1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。
2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。
3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
Georgia Institute of Technology (USA)
Martin Luther University of Halle-Wittenberg (Germany)
Worcester Polytechnic Institute (USA)
University of Lodz (Poland)
University of Perugia (Italy)
University of Vigo (Spain)
University of Amsterdam (Netherlands)
Instituto Politécnico de Bragan?a (Portugal)
University of Wisconsin-Madison (USA)
Universita' Degli Studi Di Cagliari (Italy)
Monash University Sunway Campus (Malaysia)
University of Maryland School of Medicine (USA)
University of Leipzig (Germany)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
Description: |
trans-4-Hydroxy-2-nonenoic acid is a marker of lipid peroxidation resulting from the metabolism of trans-4-hydroxy-2-nonenal.It is a gamma-hydroxybutyrate receptor ligand in the cerebral cortex and hippocampus.
|
In vivo: |
J Neurochem. 2004 Jun;89(6):1462-70. | 4-Hydroxy-trans-2-nonenoic acid is a gamma-hydroxybutyrate receptor ligand in the cerebral cortex and hippocampus.[Pubmed: 15189349] | Elevated production of 4-hydroxy-trans-2-nonenal (HNE) occurs in numerous neurological disorders involving oxidative damage. HNE is metabolized to the non-toxic 4-hydroxy-trans-2-nonenoic acid (trans-4-Hydroxy-2-nonenoic acid,HNEAcid) by aldehyde dehydrogenases in the rat cerebral cortex. METHODS AND RESULTS: Based upon the structural similarity of HNEAcid to ligands of the gamma-hydroxybutyrate (GHB) receptor, we hypothesized that HNEAcid is an endogenous ligand for the GHB receptor. HNEAcid displaced the specific binding of the GHB receptor ligand (3)H-NCS382 (30 nm) in membrane preparations of human frontal cerebral cortex and whole rat cerebral cortex with IC(50s) of 3.9 +/- 1.1 and 5.6 +/- 1.2 micro m, respectively. Inhibition was attenuated when the carboxyl group of HNEAcid was replaced with an aldehyde or an alcohol. HNEAcid (300 micro m) did not displace the binding of beta-adrenergic receptor and GABA(B) receptor antagonists, demonstrating the selectivity of HNEAcid for the GHB receptor. HNEAcid is formed in homogenates of human frontal cortical gray matter in an NAD(+)-dependent (V(Max), 0.71 nmol/min/mg) and NADP(+)-dependent (V(Max), 0.12 nmol/min/mg) manner. Lastly, (3)H-NCS382 binding is elevated 2.7-fold with age in the cerebral cortex of rats. CONCLUSIONS: Our data demonstrate that an HNE metabolite, formed in rat and human brain, is a signaling molecule analogous to other bioactive lipid peroxidation products. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
5.8065 mL |
29.0326 mL |
58.0653 mL |
116.1305 mL |
145.1632 mL |
5 mM |
1.1613 mL |
5.8065 mL |
11.6131 mL |
23.2261 mL |
29.0326 mL |
10 mM |
0.5807 mL |
2.9033 mL |
5.8065 mL |
11.6131 mL |
14.5163 mL |
50 mM |
0.1161 mL |
0.5807 mL |
1.1613 mL |
2.3226 mL |
2.9033 mL |
100 mM |
0.0581 mL |
0.2903 mL |
0.5807 mL |
1.1613 mL |
1.4516 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
部分图片展示
联系方式
电机:027-84237783
传真:027-84254680
在线QQ: 1413575084
E-Mail:manager@chemfaces.com
湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房

ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证
天然化合物与对照品的研发和生产。