反式-4-羟基-2-壬烯酸
trans-4-Hydroxy-2-nonenoic acid
|
|
产品编号 |
CFN92983 |
| CAS编号 |
95087-42-6 |
| 分子式 = 分子量 |
C9H16O3 = 172.22 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Miscellaneous |
| 植物来源 |
The herbs of Sarcandra glabra |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 反式-4-羟基-2-壬烯酸 |
CFN92983 |
95087-42-6 |
1mg |
QQ客服：2056216494 |
| 反式-4-羟基-2-壬烯酸 |
CFN92983 |
95087-42-6 |
5mg |
QQ客服：2056216494 |
| 反式-4-羟基-2-壬烯酸 |
CFN92983 |
95087-42-6 |
10mg |
QQ客服：2056216494 |
| 反式-4-羟基-2-壬烯酸 |
CFN92983 |
95087-42-6 |
20mg |
QQ客服：2056216494 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
Georgia Institute of Technology (USA)
Martin Luther University of Halle-Wittenberg (Germany)
Worcester Polytechnic Institute (USA)
University of Lodz (Poland)
University of Perugia (Italy)
University of Vigo (Spain)
University of Amsterdam (Netherlands)
Instituto Politécnico de Bragan?a (Portugal)
University of Wisconsin-Madison (USA)
Universita' Degli Studi Di Cagliari (Italy)
Monash University Sunway Campus (Malaysia)
University of Maryland School of Medicine (USA)
University of Leipzig (Germany)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
trans-4-Hydroxy-2-nonenoic acid is a marker of lipid peroxidation resulting from the metabolism of trans-4-hydroxy-2-nonenal.It is a gamma-hydroxybutyrate receptor ligand in the cerebral cortex and hippocampus.
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| In vivo: |
| J Neurochem. 2004 Jun;89(6):1462-70. | | 4-Hydroxy-trans-2-nonenoic acid is a gamma-hydroxybutyrate receptor ligand in the cerebral cortex and hippocampus.[Pubmed: 15189349] | Elevated production of 4-hydroxy-trans-2-nonenal (HNE) occurs in numerous neurological disorders involving oxidative damage. HNE is metabolized to the non-toxic 4-hydroxy-trans-2-nonenoic acid (trans-4-Hydroxy-2-nonenoic acid,HNEAcid) by aldehyde dehydrogenases in the rat cerebral cortex.
METHODS AND RESULTS:
Based upon the structural similarity of HNEAcid to ligands of the gamma-hydroxybutyrate (GHB) receptor, we hypothesized that HNEAcid is an endogenous ligand for the GHB receptor. HNEAcid displaced the specific binding of the GHB receptor ligand (3)H-NCS382 (30 nm) in membrane preparations of human frontal cerebral cortex and whole rat cerebral cortex with IC(50s) of 3.9 +/- 1.1 and 5.6 +/- 1.2 micro m, respectively. Inhibition was attenuated when the carboxyl group of HNEAcid was replaced with an aldehyde or an alcohol. HNEAcid (300 micro m) did not displace the binding of beta-adrenergic receptor and GABA(B) receptor antagonists, demonstrating the selectivity of HNEAcid for the GHB receptor. HNEAcid is formed in homogenates of human frontal cortical gray matter in an NAD(+)-dependent (V(Max), 0.71 nmol/min/mg) and NADP(+)-dependent (V(Max), 0.12 nmol/min/mg) manner. Lastly, (3)H-NCS382 binding is elevated 2.7-fold with age in the cerebral cortex of rats.
CONCLUSIONS:
Our data demonstrate that an HNE metabolite, formed in rat and human brain, is a signaling molecule analogous to other bioactive lipid peroxidation products. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
5.8065 mL |
29.0326 mL |
58.0653 mL |
116.1305 mL |
145.1632 mL |
| 5 mM |
1.1613 mL |
5.8065 mL |
11.6131 mL |
23.2261 mL |
29.0326 mL |
| 10 mM |
0.5807 mL |
2.9033 mL |
5.8065 mL |
11.6131 mL |
14.5163 mL |
| 50 mM |
0.1161 mL |
0.5807 mL |
1.1613 mL |
2.3226 mL |
2.9033 mL |
| 100 mM |
0.0581 mL |
0.2903 mL |
0.5807 mL |
1.1613 mL |
1.4516 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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