丙位癸内酯

gamma-Decalactone

	产品编号	CFN70189
	CAS编号	706-14-9
	分子式 = 分子量	C₁₀H₁₈O₂ = 170.2
	产品纯度	>=98%
	物理属性	Oil
	化合物类型	Miscellaneous
	植物来源	From the peroxisomal beta-oxidation of ricinoleic acid by yeasts.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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丙位癸内酯	CFN70189	706-14-9	10mg	QQ客服：3004468091
丙位癸内酯	CFN70189	706-14-9	20mg	QQ客服：3004468091
丙位癸内酯	CFN70189	706-14-9	50mg	QQ客服：3004468091
丙位癸内酯	CFN70189	706-14-9	100mg	QQ客服：3004468091

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Chulalongkorn University (Thailand)

Agricultural Research Organization (ARO) (Israel)

Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)

University of Amsterdam (Netherlands)

University of Leipzig (Germany)

University of Melbourne (Australia)

John Innes Centre (United Kingdom)

University of Hertfordshire (United Kingdom)

Hamdard University (India)

Shanghai Institute of Biochemistry and Cell Biology (China)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

Sri Ramachandra University (India)

Anna University (India)

Funda??o Universitária de Desenvolvimento (Brazil)

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Description:

gamma-Decalactone is a valuable aroma compound.could be food industry.

In vitro:

Applied microbiology and biotechnology, 1998, 49(3):295.

Peroxisomal beta-oxidation activities and gamma-decalactone production by the yeast Yarrowia lipolytica.[Reference: WebLink]

gamma-Decalactone is a peachy aroma compound resulting from the peroxisomal beta-oxidation of ricinoleic acid by yeasts.
METHODS AND RESULTS:
The expression levels of acyl-CoA oxidase (gene deletion) and 3-ketoacyl-CoA thiolase activities (gene amplification on replicative plasmids) were modified in the yeast Yarrowia lipolytica. The effects of these modifications on beta-oxidation were measured. Overexpression of thiolase activity did not have any effect on the overall beta-oxidation activity. The disruption of one of the acyl-CoA oxidase genes resulted in an enhanced activity. The enhancement led to an increase of overall beta-oxidation activity but reduced the gamma-decalactone production rates. This seemed to indicate a non-rate-limiting role for beta-oxidation in the biotransformation of ricinoleic acid to gamma-decalactone by the yeast Yarrowia lipolytica. All strains produced and then consumed gamma-decalactone. We checked the ability of the different strains to consume gamma-decalactone in a medium containing the lactone as sole carbon source. The consumption of the strain overexpressing acyl-CoA oxidase activity was higher than that of the wild-type strain.
CONCLUSIONS:
We concluded that peroxisomal beta-oxidation is certainly involved in gamma-decalactone catabolism by the yeast Y. lipolytica. The observed production rates probably depend on an equilibrium between production and consumption of the lactone.

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.8754 mL	29.3772 mL	58.7544 mL	117.5088 mL	146.886 mL
5 mM	1.1751 mL	5.8754 mL	11.7509 mL	23.5018 mL	29.3772 mL
10 mM	0.5875 mL	2.9377 mL	5.8754 mL	11.7509 mL	14.6886 mL
50 mM	0.1175 mL	0.5875 mL	1.1751 mL	2.3502 mL	2.9377 mL
100 mM	0.0588 mL	0.2938 mL	0.5875 mL	1.1751 mL	1.4689 mL