(+)-beta-柏木烯

(+)-beta-Cedrene

	产品编号	CFN91636
	CAS编号	546-28-1
	分子式 = 分子量	C₁₅H₂₄ = 204.35
	产品纯度	>=98%
	物理属性	Oil
	化合物类型	Sesquiterpenoids
	植物来源	The heartwoods of Platycladus orientalis
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
(+)-beta-柏木烯	CFN91636	546-28-1	1mg	QQ客服：2056216494
(+)-beta-柏木烯	CFN91636	546-28-1	5mg	QQ客服：2056216494
(+)-beta-柏木烯	CFN91636	546-28-1	10mg	QQ客服：2056216494
(+)-beta-柏木烯	CFN91636	546-28-1	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Vienna (Austria)

University of South Australia (Australia)

Mendel University in Brno (Czech Republic)

University of Indonesia (Indonesia)

Universidade Federal de Goias (UFG) (Brazil)

Universidad de Buenos Aires (Argentina)

University of Padjajaran (Indonesia)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

University of Wisconsin-Madison (USA)

Institute of Chinese Materia Medica (China)

Michigan State University (USA)

University of Liège (Belgium)

Sant Gadge Baba Amravati University (India)

University of Illinois (USA)

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Description:

β-cedrene are bioactive sesquiterpenes found in cedar essential oil and exert antiseptic, anti-inflammatory, antispasmodic, tonic, astringent, diuretic, sedative, insecticidal, and antifungal activities. β-Cedrene is a potent and competitive inhibitor of CYP2B6-mediated bupropion hydroxylase, and β-cedrene moderately blocks CYP3A4.

In vivo:

Physiol Behav . 2018 May 15;189:50-58.

The anxiolytic effect of Juniperus virginiana L. essential oil and determination of its active constituents[Pubmed: 29326032]

Essential oil from Juniperus virginiana L. (eastern red cedarwood essential oil, CWO) has been used to relax mind and enhance comfort for medical purposes. Few reports showed its effect on anxiety behaviors in animal models. The present study investigated the anxiolytic effect of CWO using two anxiety tests in mice, then determined the major active constituents, examined the change of neurotransmitters after intraperitoneal (i.p.) administration. Analysis using GC/MS revealed that the CWO contained (-)-α-cedrene (28.11%), (+)-β-cedrene (7.81%), (-)-thujopsene (17.71%) and (+)-cedrol (24.58%). CWO at 400-800mg/kg increased the percentage of open arm entries and the percentage of the time spent in open arms in the elevated plus maze (EPM), suggesting that the oil has anxiolytic effect. However, it didn't show anxiolytic effect in the light-dark box (LDB) test. Tests of the cedrene did not show anxiolytic effect in either test, but rather induced anxiety-related behaviors and inhibited the locomotor activity in EPM and LDB. Cedrol produced significant anxiolytic effect in both EPM and LDB tests at 400-1600mg/kg and 800-1600mg/kg, respectively. A more significant increase in locomotor activity was observed in cedrol at 200-1600mg/kg administration than CWO. CWO increased the 5-hydroxytryptamine (5-HT) concentration at 800mg/kg, whereas it didn't affect the dopamine (DA) concentration. Cedrol significantly reduced the DA level at 100-200mg/kg and elevated the 5-HT level at 1200-1600mg/kg. Moreover, it changed the ratio of 5-hydroxyindoleacetic acid/5-HT and 3, 4-dihydroxyphenyl acetic acid/DA at 1200-1600mg/kg. CWO and cedrol, in particular might act in an anxiolytic effect through the 5-HTnergic and DAnergic pathways.

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.8936 mL	24.4678 mL	48.9356 mL	97.8713 mL	122.3391 mL
5 mM	0.9787 mL	4.8936 mL	9.7871 mL	19.5743 mL	24.4678 mL
10 mM	0.4894 mL	2.4468 mL	4.8936 mL	9.7871 mL	12.2339 mL
50 mM	0.0979 mL	0.4894 mL	0.9787 mL	1.9574 mL	2.4468 mL
100 mM	0.0489 mL	0.2447 mL	0.4894 mL	0.9787 mL	1.2234 mL