| In vitro: |
| Biosci Biotechnol Biochem. 2001 Jun;65(6):1395-8. | | Four polyoxygenated cyclohexenes from the Chinese tree, Uvaria purpurea.[Pubmed: 11471741 ] |
METHODS AND RESULTS:
Two novel polyoxygenated cyclohexenes, 6-methoxyZeylenol (3) and 2-acetoxyzeylenone (4), together with two known compounds, Zeylenol (1) and zeylenone (2), were isolated from the heartwood of the Chinese tree, Uvaria purpurea.
CONCLUSIONS:
Zeylenol (1) and zeylenone (2) both showed inhibitory activity toward the root growth of Lactuca sativa. Their structures were established by spectroscopic and chemical methods. |
|
| In vivo: |
| Scienceasia, 2013, 39(6):610-614. | | Anti-inflammatory and anticancer activities of (-)-zeylenol from stems of Uvaria grandiflora.[Reference: WebLink] | Uvaria grandiflora has stimulated rigorous phytochemical investigation aimed at determining chemical structures and biological activities. In recent years, many polyoxygenated cyclohexenes have been isolated from this genus. This study reports that Zeylenol isolated from the stems of U. grandiflora possess potential anti-inflammatory, anticancer, and caspase-3 activities.
METHODS AND RESULTS:
The structure of this compound was elucidated from spectroscopic analysis, particularly 2D NMR techniques. The anti-inflammatory effect and toxicity of Zeylenol were evaluated in animal models and compared to that of reference drugs. In addition, the cytotoxicity of the isolated compound against human breast cancer MDA-MB231 and hepatocellular carcinoma HepG2 cell lines were studied. The test (-)-Zeylenol at the dose of 1 mg/ear significantly inhibited oedema formation by 90%, 69%, 52%, and 52% after 15, 30, 60, and 120 min, respectively. Zeylenol was found to be toxic to both MDA-MB231 and HepG2 cells in a dose response manner with IC50 values of 54 +/- 10 and > 80 mu M, respectively. The compound induced MDA-MB231 cell apoptosis via caspase-3 activation.
CONCLUSIONS:
Zeylenol probably possesses anti-inflammatory activity by inhibiting the synthesis or release of various inflammatory mediators and might be used to induce human breast cancer MDA-MB231 cell apoptosis. |
|
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)
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