黄色当归醇B

Xanthoangelol B

	产品编号	CFN93557
	CAS编号	132998-81-3
	分子式 = 分子量	C₂₅H₂₈O₅ = 408.49
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Chalcones
	植物来源	The roots of Angelica keiskei.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
黄色当归醇B	CFN93557	132998-81-3	1mg	QQ客服：2056216494
黄色当归醇B	CFN93557	132998-81-3	5mg	QQ客服：2056216494
黄色当归醇B	CFN93557	132998-81-3	10mg	QQ客服：2056216494
黄色当归醇B	CFN93557	132998-81-3	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Korea Food Research Institute(KFRI) (Korea)

Osmania University (India)

University of Amsterdam (Netherlands)

University of Parma (Italy)

Georgia Institute of Technology (USA)

Wageningen University (Netherlands)

University of Limpopo (South Africa)

University of Mysore (India)

FORTH-IMBB (Greece)

Universidade do Porto (Portugal)

Massachusetts General Hospital (USA)

Harvard University (USA)

Stanford University (USA)

Cancer Research Initatives Foundation(CARIF) (Malaysia)

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Description:

Xanthoangelol B and its derivative PM-56 were shown to bind directly to SaeS and inhibit its histidine kinase activity, which suggests a possibility of a broad spectrum inhibitor of histidine kinases. Xanthoangelol B inhibited the phenylephrine-induced vasoconstriction most strongly, and the inhibitory mechanism of it on phenylephrine-induced vasoconstriction might involve the direct inhibition of smooth muscle functions through the reduction of [Ca2+]i elevation without affecting EDRF/NO production.

Targets:

Calcium Channel | NO | NMDA receptor

In vitro:

Planta Med. 2001 Apr;67(3):230-5.

Artery relaxation by chalcones isolated from the roots of Angelica keiskei.[Pubmed: 11345693 ]

METHODS AND RESULTS:
An EtOAc-soluble fraction from a 50% EtOH extract of the roots of Angelica keiskei inhibited phenylephrine-induced vasoconstriction in rat aortic rings, while an EtOAc-insoluble fraction had no effect at 100 micrograms/ml. Five active substances isolated from the EtOAc-soluble fraction of the roots were identified as xanthoangelol (1), 4-hydroxyderricin (2), and xanthoangelol B (3), xanthoangelol E (4) and xanthoangelol F (5), which inhibited phenylephrine-induced vasoconstriction at the concentrations of 10-100 micrograms/ml. It was found that xanthoangelol (1), 4-hydroxyderricin (2), and xanthoangelols E (4) and F (5) inhibited the phenylephrine-induced vasoconstriction through endothelium-dependent endothelium-derived relaxing factor (EDRF) production and/or nitric oxide (NO) production. Among the five chalcones, xanthoangelol B (3) inhibited the phenylephrine-induced vasoconstriction most strongly, and it inhibited the phenylephrine-induced vasoconstriction in the presence or absence of endothelium and in the presence or absence of NG-monomethyl-L-arginine (L-NMMA) (an NO synthetase inhibitor). Furthermore, 4-hydroxyderricin (2) and xanthoangelol B (3) at concentrations of 10-100 micrograms/ml concentration-dependently inhibited the elevation of intracellular free calcium [Ca2+]i induced by phenylephrine.
CONCLUSIONS:
These results demonstrate that compounds 1, 2, 4 and 5 inhibit phenylephrine-induced vasoconstriction through endothelium-dependent production of EDRF/NO and/or through the reduction of the [Ca2+]i elevation induced by phenylephrine. On the other hand, the inhibitory mechanism of compound 3 on phenylephrine-induced vasoconstriction might involve the direct inhibition of smooth muscle functions through the reduction of [Ca2+]i elevation without affecting EDRF/NO production.

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.448 mL	12.2402 mL	24.4804 mL	48.9608 mL	61.201 mL
5 mM	0.4896 mL	2.448 mL	4.8961 mL	9.7922 mL	12.2402 mL
10 mM	0.2448 mL	1.224 mL	2.448 mL	4.8961 mL	6.1201 mL
50 mM	0.049 mL	0.2448 mL	0.4896 mL	0.9792 mL	1.224 mL
100 mM	0.0245 mL	0.1224 mL	0.2448 mL	0.4896 mL	0.612 mL

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Pilloin; Pilloin	CFN96503	32174-62-2	C₁₇H₁₄O₆ = 314.29	10mg	QQ客服：215959384
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Nemoralisin; Nemoralisin	CFN97516	942480-13-9	C₂₀H₂₈O₄ = 332.4	5mg	QQ客服：3257982914
款冬碱; Tussilagine	CFN00272	80151-77-5	C₁₀H₁₇NO₃ = 199.25	5mg	QQ客服：1413575084