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  • Withanone

    Withanone

    Withanone
    产品编号 CFN70327
    CAS编号 27570-38-3
    分子式 = 分子量 C28H38O6 = 470.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Withania somnifera
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Withanone CFN70327 27570-38-3 1mg QQ客服:215959384
    Withanone CFN70327 27570-38-3 5mg QQ客服:215959384
    Withanone CFN70327 27570-38-3 10mg QQ客服:215959384
    Withanone CFN70327 27570-38-3 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Yale University (USA)
  • University of Maryland (USA)
  • Gyeongsang National University (Korea)
  • University of Stirling (United Kingdom)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • University of Lodz (Poland)
  • Weizmann Institute of Science (Israel)
  • Nicolaus Copernicus Uniwersity (Poland)
  • University of Illinois at Chicago (USA)
  • Kamphaengphet Rajabhat University (Thailand)
  • Charles University in Prague (Czech Republic)
  • University of Maryland School of Medicine (USA)
  • Universiti Sains Malaysia (Malaysia)
  • Universidad Veracuzana (Mexico)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Oncotarget.2015, 6(31):30831-49
  • Molecules.2022, 27(13):4227.
  • Molecules2022, 27(9):2613.
  • J of Archaeological Science:Reports2024, 53:104298
  • Int J Pharm.2022, 618:121636.
  • Foods2023, 12(23), 4342.
  • Applied Biological Chemistry2022, 65(77).
  • Molecules.2022, 27(19):6681.
  • Phytomedicine.2019, 57:95-104
  • Front Cell Infect Microbiol.2018, 8:292
  • Eur J Pharmacol.2023, 960:176121.
  • Microchemical Journal2024: 196:109676.
  • Front Pharmacol.2020, 11:683.
  • Kor. J. Herbol.2022, 37(5): 89-96.
  • Plant Physiol.2024, 194(4):2580-2599.
  • Biomolecules.2023, 13(2):227.
  • BMC Plant Biol.2022, 22(1):128.
  • Biomed Pharmacother.2023, 166:115329.
  • J Mol Med (Berl).2018, 96(7):661-672
  • Drug Dev Res.2022, 83(7):1673-1682.
  • Molecules.2022, 27(7):2116.
  • Nutrients2020, 12(3):811.
  • J Biochem Mol Toxicol.2017, 31(9)
  • ...
  • 生物活性
    Description: Withanone can affords protection against NMDA-induced excitotoxicity in neuron-like cells, it may serve as potential neuroprotective agent, it shows promise in Alzheimer's disease treatment because of cognitive benefits. Withanone as a potential candidate molecule in cancer therapy.
    Targets: MCP-1 | IL Receptor | NO | TNF-α | NMDA receptor | ROS | Bcl-2/Bax | DNA | p53 | PARP | Beta Amyloid
    In vitro:
    Dar N J , Bhat J A Molecular Neurobiology, 2017, 54(7):5061-5073.
    Withanone, an Active Constituent from Withania somnifera, Affords Protection Against NMDA-Induced Excitotoxicity in Neuron-Like Cells.[Reference: WebLink]
    Withania somnifera has immense pharmacologic and clinical uses. Owing to its similar pharmacologic activity as that of Korean Ginseng tea, it is popularly called as Indian ginseng. In most cases, extracts of this plant have been evaluated against various diseases or models of disease. However, little efforts have been made to evaluate individual constituents of this plant for neurodegenerative disorders.
    METHODS AND RESULTS:
    Present study was carried out to evaluate Withanone, one of the active constituents of Withania somnifera against NMDA-induced excitotoxicity in retinoic acid, differentiated Neuro2a cells. Cells were pre-treated with 5, 10 and 20 μM doses of Withanone and then exposed to 3-mM NMDA for 1 h. MK801, a specific NMDA receptor antagonist, was used as positive control. The results indicated that NMDA induces significant death of cells by accumulation of intracellular Ca2+, generation of reactive oxygen species (ROS), loss of mitochondrial membrane potential, crashing of Bax/Bcl-2 ratio, release of cytochrome c, increased caspase expression, induction of lipid peroxidation as measured by malondialdehyde levels and cleavage of poly(ADP-ribose) polymerase-1 (Parp-1), which is indicative of DNA damage. All these parameters were attenuated with various doses of Withanone pre-treatment.
    CONCLUSIONS:
    These results suggest that Withanone may serve as potential neuroprotective agent.
    Journal of Biotechnology, 2013, 168(2):229-233.
    Withanone as an inhibitor of survivin: A potential drug candidate for cancer therapy.[Reference: WebLink]
    Survivin, the smallest inhibitor of apoptosis protein, which has been reported to be highly expressed in almost all known cancers, plays a dual role in survival as well as the proliferation of cancer cells. It inhibits apoptosis by inhibiting caspases as well as facilitating mitosis by becoming a part of chromosomal passenger complex through its BIR5 domain.
    METHODS AND RESULTS:
    Docking studies carried out with herbal ligand withanone derived from roots of Withania somnifera have shown strong binding affinity of −19.1088 kJ/mol with BIR5 domain of survivin and in turn interferes with inhibitory action against caspases and may lead to apoptosis. Binding of withanone at BIR5 domain of survivin may also interfere with chromosomal passenger complex and lead to halt the mitotic process within the cancer cell.
    CONCLUSIONS:
    Docking studies support various experimental outcomes and suggest withanone as a potential candidate molecule in cancer therapy.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1249 mL 10.6247 mL 21.2495 mL 42.4989 mL 53.1237 mL
    5 mM 0.425 mL 2.1249 mL 4.2499 mL 8.4998 mL 10.6247 mL
    10 mM 0.2125 mL 1.0625 mL 2.1249 mL 4.2499 mL 5.3124 mL
    50 mM 0.0425 mL 0.2125 mL 0.425 mL 0.85 mL 1.0625 mL
    100 mM 0.0212 mL 0.1062 mL 0.2125 mL 0.425 mL 0.5312 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    反式-桂皮酸酐; trans-Cinnamic anhydride CFN92934 21947-71-7 C18H14O3 = 278.30 5mg QQ客服:215959384
    3,5-二甲氧基苯酚; 3,5-Dimethoxyphenol CFN96891 500-99-2 C8H10O3 = 154.16 20mg QQ客服:2159513211
    Pterocarpadiol D; Pterocarpadiol D CFN89484 2055882-23-8 C16H16O6 = 304.29 5mg QQ客服:2159513211
    8-表-密花豚草素; 8-epi-Confertin CFN95509 110115-60-1 C15H20O3 = 248.3 5mg QQ客服:2159513211

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