牡荆素-2''-O-鼠李糖苷

Vitexin-2''-O-rhamnoside

	产品编号	CFN98177
	CAS编号	64820-99-1
	分子式 = 分子量	C₂₇H₃₀O₁₄ = 578.52
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Flavonoids
	植物来源	The leaves of Crataegus pinnatifida Bunge
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
牡荆素-2''-O-鼠李糖苷	CFN98177	64820-99-1	10mg	QQ客服：1413575084
牡荆素-2''-O-鼠李糖苷	CFN98177	64820-99-1	20mg	QQ客服：1413575084
牡荆素-2''-O-鼠李糖苷	CFN98177	64820-99-1	50mg	QQ客服：1413575084
牡荆素-2''-O-鼠李糖苷	CFN98177	64820-99-1	100mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Funda??o Universitária de Desenvolvimento (Brazil)

Universit?t Basel (Switzerland)

Johannes Gutenberg University Mainz (JGU) (Germany)

University of East Anglia (United Kingdom)

Wroclaw Medical University (Poland)

Sapienza University of Rome (Italy)

Universidade Federal de Santa Catarina (Brazil)

Martin Luther University of Halle-Wittenberg (Germany)

University of Bonn (Germany)

University of Helsinki (Finland)

Uniwersytet Jagielloński w Krakowie (Poland)

Sanford Burnham Medical Research Institute (USA)

Universidad Industrial de Santander (Colombia)

Universidad de Buenos Aires (Argentina)

More...

Description:

Vitexin-2''-O-rhamnoside contributes to the protection against H₂O₂ -mediated oxidative stress damage and could be safely used for a wide range of concentrations.It has low bioavailability, mainly related to its poor absorption in the intestine.

Targets:

P450 (e.g. CYP17) | P-gp

In vitro:

J Pharm Pharmacol. 2014 Jul;66(7):988-97.

Effects of vitexin-2"-O-rhamnoside and vitexin-4"-O-glucoside on growth and oxidative stress-induced cell apoptosis of human adipose-derived stem cells.[Pubmed: 24533889]

Vitexin-2''-O-rhamnoside(VOR) and vitexin-4"-O-glucoside (VOG) are the two main flavonoid glycosides of the leaves of Cratagus pinnatifida Bge. var. major N. E. Br. that has been widely used for the treatment of cardiovascular system diseases. In this study, we simultaneously investigated the influence of Vitexin-2''-O-rhamnoside and VOG on human adipose-derived stem cells (hADSCs) injury induced by hydrogen peroxide (H2 O2 ) to further characterize their anti-oxidative and anti-apoptotic activity.
METHODS AND RESULTS:
hADSCs were isolated, cultured in vitro and pretreated with 62.5 μm Vitexin-2''-O-rhamnoside or 120 μm VOG for 24 h and then exposed to 500 μm H2 O2 for an additional 4 h.Pretreatment of hADSCs with Vitexin-2''-O-rhamnoside and VOG was demonstrated to significantly ameliorate the toxicity and apoptosis effects, such as morphological distortion, nuclear condensation, decreased intracellular caspase-3 activity and percentage of cells in apoptosis/necrosis by using morphological assay, immunocytochemistry and flow cytometric evaluation. In addition, Vitexin-2''-O-rhamnoside and VOG caused no cytotoxic effect on hADSCs at concentrations up to 250 and 480 μm, respectively.
CONCLUSIONS:
Our results indicated that both Vitexin-2''-O-rhamnoside and VOG contribute to the protection against H2 O2 -mediated oxidative stress damage and could be safely used for a wide range of concentrations.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Fimepinostat (CUDC-907); Fimepinostat (CUDC-907)	CFN60286	1339928-25-4	C₂₃H₂₄N₈O₄S = 508.55	5mg	QQ客服：215959384
右旋香芹酮; (+)-Carvone	CFN70085	2244-16-8	C₁₀H₁₄O = 150.2	20mg	QQ客服：1457312923
8beta-马豆酰所基木香烃内酯; 8beta-Tigloyloxycostunolide	CFN96813	96850-21-4	C₂₀H₂₆O₄ = 330.42	5mg	QQ客服：1457312923
Moellendorffilin; Moellendorffilin	CFN92638	105099-87-4	C₂₆H₂₀O₁₀ = 492.4	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7285 mL	8.6427 mL	17.2855 mL	34.571 mL	43.2137 mL
5 mM	0.3457 mL	1.7285 mL	3.4571 mL	6.9142 mL	8.6427 mL
10 mM	0.1729 mL	0.8643 mL	1.7285 mL	3.4571 mL	4.3214 mL
50 mM	0.0346 mL	0.1729 mL	0.3457 mL	0.6914 mL	0.8643 mL
100 mM	0.0173 mL	0.0864 mL	0.1729 mL	0.3457 mL	0.4321 mL