别一叶萩碱

Viroallosecurinine

	产品编号	CFN96450
	CAS编号	1857-30-3
	分子式 = 分子量	C₁₃H₁₅NO₂ = 217.27
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The roots of Securinega virosa
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
别一叶萩碱	CFN96450	1857-30-3	1mg	QQ客服：1457312923
别一叶萩碱	CFN96450	1857-30-3	5mg	QQ客服：1457312923
别一叶萩碱	CFN96450	1857-30-3	10mg	QQ客服：1457312923
别一叶萩碱	CFN96450	1857-30-3	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Aarhus University (Denmark)

Utah State University (USA)

University of the Basque Country (Spain)

University of South Australia (Australia)

Biotech R&D Institute (USA)

University of Stirling (United Kingdom)

Kyoto University (Japan)

Leibniz Institute of Plant Biochemistry (Germany)

University of Minnesota (USA)

Utrecht University (Netherlands)

University of Melbourne (Australia)

Universidade Católica Portuguesa (Portugal)

Uniwersytet Gdański (Poland)

Texas A&M University (USA)

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Description:

Virosecurinine and viroallosecurinine were isolated as two cytotoxic alkaloids from the leaves of Securinega virosa. Viroallosecurinine exhibits a MIC of 0.48 micrograms/ml for Pseudomonas aeruginosa and Staphylococcus aureus.

Targets:

Antifection

In vitro:

Nat Prod Res. 2007 Mar;21(3):234-42.

Callus of Securinega suffruticosa, a cell line accumulates dextro Securinega alkaloids.[Pubmed: 17365714 ]

Investigations on callus cultures of Securinega suffruticosa indicated that the cell line of S. suffruticosa callus was able to accumulate four known Securinega alkaloids with dextro rotation but not levo rotation as reported before: virosecurinine (1), viroallosecurinine (2), 14,15-dihydrovirosecurinine (3) and ent-phyllanthidine (4). Time course studies on the growth of callus cultures were carried out. The effects of different plant growth regulators, sucrose concentrations on callus growth and virosecurinine production were also reported.

J Ethnopharmacol. 1990 Feb;28(1):129-33.

Antibacterial activity of the leaves of Phyllanthus discoideus.[Pubmed: 2156112]

The lyophilized aqueous extract (LWE) from the leaves of Phyllanthus discoideus was found to show an antibacterial activity.
METHODS AND RESULTS:
The alkaloid fraction obtained from LWE inhibited the growth of Escherichia coli and Enterococcus faecium (MIC = 1.6 mg/ml), Pseudomonas aeruginosa (MIC = 0.78 mg/ml), Staphylococcus aureus and Mycobacterium smegmatis (MIC = 0.2 mg/ml). Among the alkaloids identified, Viroallosecurinine and securinine showed a high activity. Viroallosecurinine exhibited a MIC of 0.48 micrograms/ml for Ps. aeruginosa and Staph. aureus.
CONCLUSIONS:
This alkaloid is bactericidal since the yields of MIC/MBC were less than 1. The MIC of securinine was 0.500 mg/ml for E. coli, Staph. aureus and Myc. smegmatis. These effects of Phyllanthus discoideus leaf extracts support some of the local uses of the plant in traditional therapy.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Paxiphylline E; Paxiphylline E	CFN99094	1092555-03-7	C₂₃H₂₉NO₅ = 399.5	5mg	QQ客服：3257982914
Daphnicyclidin D ; Daphnicyclidin D	CFN96777	385384-24-7	C₂₃H₂₇NO₄ = 381.47	5mg	QQ客服：3257982914
Daphnicyclidin F; Daphnicyclidin F	CFN96778	385384-26-9	C₂₃H₂₇NO₅ = 397.47	5mg	QQ客服：2056216494
虎皮楠生物碱B; Daphniyunnine B	CFN97448	881388-88-1	C₂₁H₂₉NO₃ = 343.5	5mg	QQ客服：1457312923
Daphnicyclidin H ; Daphnicyclidin H	CFN96776	385384-29-2	C₂₃H₂₉NO₅ = 399.48	5mg	QQ客服：2056216494
Daphnicyclidin I ; Daphnicyclidin I	CFN96733	1467083-10-8	C₂₂H₂₆N₂O₃ = 366.46	5mg	QQ客服：2056216494
Hybridaphniphylline A; Hybridaphniphylline A	CFN96737	1467083-07-3	C₃₇H₄₇NO₁₁ = 681.77	5mg	QQ客服：1457312923
Hybridaphniphylline B; Hybridaphniphylline B	CFN96740	1467083-09-5	C₃₇H₄₇NO₁₁ = 681.77	5mg	QQ客服：2159513211
长春素B; 白饭树碱B; Virosine B	CFN96449	1052228-70-2	C₁₃H₁₇NO₃ = 235.28	5mg	QQ客服：215959384
一叶萩醇A; Securinol A	CFN96679	5008-48-0	C₁₃H₁₇NO₃ = 235.28	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.6026 mL	23.0128 mL	46.0257 mL	92.0514 mL	115.0642 mL
5 mM	0.9205 mL	4.6026 mL	9.2051 mL	18.4103 mL	23.0128 mL
10 mM	0.4603 mL	2.3013 mL	4.6026 mL	9.2051 mL	11.5064 mL
50 mM	0.0921 mL	0.4603 mL	0.9205 mL	1.841 mL	2.3013 mL
100 mM	0.046 mL	0.2301 mL	0.4603 mL	0.9205 mL	1.1506 mL