长春胺

Vincamine

	产品编号	CFN90464
	CAS编号	1617-90-9
	分子式 = 分子量	C₂₁H₂₆N₂O₃ = 354.44
	产品纯度	>=98%
	物理属性	Cryst.
	化合物类型	Alkaloids
	植物来源	The herbs of Catharanthus roseus (L.) G. Don.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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长春胺	CFN90464	1617-90-9	10mg	QQ客服：1413575084
长春胺	CFN90464	1617-90-9	20mg	QQ客服：1413575084
长春胺	CFN90464	1617-90-9	50mg	QQ客服：1413575084
长春胺	CFN90464	1617-90-9	100mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

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Uniwersytet Jagielloński w Krakowie (Poland)

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Description:

Vincamine is a plant alkaloid used clinically as a peripheral vasodilator that increases cerebral blood flow and oxygen and glucose utilization by neural tissue to combat the effect of aging. Vincamine has contractile and relaxant actions on the guinea pig trachealis, may be due to the generation of prostaglandins and to changes in the membrane Ca2+ fluxes and/or the intracellular Ca2+ distribution. Vincamine alleviates Amyloid-β 25-35 peptides-induced cytotoxicity in PC12 cells.

Targets:

Calcium Channel | Potassium Channel | Beta Amyloid | PI3K | Akt | SOD

In vitro:

Eur J Pharmacol. 1989 Mar 29;162(3):387-95.

Trachealis responses induced by vincamine and vinpocetine; inhibition by indomethacin and Ca2+ dependence.[Pubmed: 2744076]

METHODS AND RESULTS:
Vincamine in low concentrations induced a sustained contraction of the isolated guinea pig trachealis with long latency and slow onset and, in high concentrations, it induced relaxation which was potentiated in the precontracted trachealis. Vinpocetine had actions similar to those of vincamine on trachealis, however its relaxant effect was more pronounced. The vincamine-induced trachealis contraction was not changed by substance P desensitization, was reduced by tetrodotoxin, nifedipine and low Ca2+ high Mg2+ solution and increased in nominally Ca2+-free solution. The vincamine-induced relaxation of precontracted trachealis was increased by guanethidine and was not affected by propranolol, high Mg2+-low Ca2+ solution and tetrodotoxin. Vincamine- and vinpocetine-induced trachealis contraction as well as vinpocetine-induced relaxation at basal tension were abolished by indomethacin. Vincamine in a low concentration shifted to the left the concentration-effect curve for CaCl2 in the K+-depolarized trachealis, and shifted it to the right at a high concentration.
CONCLUSIONS:
Our results indicate that the contractile and relaxant actions of vincamine and vinpocetine on the guinea pig trachealis may be due to the generation of prostaglandins and to changes in the membrane Ca2+ fluxes and/or the intracellular Ca2+ distribution.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
哈尔马拉西定碱; Harmalacidine	CFN91937	26579-69-1	C₁₂H₁₂N₂O₂ = 216.24	5mg	QQ客服：1457312923
哈尔酚; Harmol	CFN91825	487-03-6	C₁₂H₁₀N₂O = 198.2	20mg	QQ客服：2159513211
盐酸去氢骆驼蓬碱; Harmine hydrochloride	CFN90341	343-27-1	C₁₃H₁₂N₂O.HCl = 248.71	20mg	QQ客服：2056216494
哈尔碱；哈尔明碱；肉叶云香碱；去氢骆驼蓬碱; Harmine	CFN98676	442-51-3	C₁₃H₁₂N₂O = 212.3	20mg	QQ客服：1457312923
羟基吴茱萸碱; Hydroxyevodiamine	CFN90347	1238-43-3	C₁₉H₁₇N₃O₂ = 319.36	5mg	QQ客服：3257982914
长春胺; Vincamine	CFN90464	1617-90-9	C₂₁H₂₆N₂O₃ = 354.44	20mg	QQ客服：1413575084
长春西汀; Vinpocetine	CFN90467	42971-09-5	C₂₂H₂₆N₂O₂ = 350.45	20mg	QQ客服：1457312923
7-甲氧基-beta-咔啉-1-丙酸; 7-Methoxy-beta-carboline-1-propionic acid	CFN92013	137756-13-9	C₁₅H₁₄N₂O₃ = 270.3	5mg	QQ客服：1413575084
7-羟基-beta-咔啉-1-丙酸; 7-Hydroxy-beta-carboline-1-propionic acid	CFN92206	215934-15-9	C₁₄H₁₂N₂O₃ = 256.3	5mg	QQ客服：1457312923
Ethyl beta-carboline-1-propionate; Ethyl beta-carboline-1-propionate	CFN92746	90686-24-1	C₁₆H₁₆N₂O₂ = 268.3	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8214 mL	14.1068 mL	28.2135 mL	56.427 mL	70.5338 mL
5 mM	0.5643 mL	2.8214 mL	5.6427 mL	11.2854 mL	14.1068 mL
10 mM	0.2821 mL	1.4107 mL	2.8214 mL	5.6427 mL	7.0534 mL
50 mM	0.0564 mL	0.2821 mL	0.5643 mL	1.1285 mL	1.4107 mL
100 mM	0.0282 mL	0.1411 mL	0.2821 mL	0.5643 mL	0.7053 mL