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  • Trifloroside

    • Trifloroside

    Trifloroside

    Trifloroside
    		产品编号 CFN96606
    CAS编号 53823-10-2
    分子式 = 分子量 C35H42O20 = 782.70
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Iridoids
    植物来源 The roots of Gentiana scabra.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Trifloroside CFN96606 53823-10-2 1mg QQ客服：2159513211
    Trifloroside CFN96606 53823-10-2 5mg QQ客服：2159513211
    Trifloroside CFN96606 53823-10-2 10mg QQ客服：2159513211
    Trifloroside CFN96606 53823-10-2 20mg QQ客服：2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Wageningen University (Netherlands)
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  • Rio de Janeiro State University (Brazil)
  • Shanghai Institute of Organic Chemistry (China)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2023, 25(1):283.
  • Scientific World Journal.2014, 2014:654193
  • iScience.2020, 23(2):100849.
  • Molecules.2019, 24(4):E709
  • Nutrients.2019, 12(1)
  • LWT2020, 124:109163
  • Pharmacological Reports2020, 1-9
  • Cells.2021, 10(10):2633.
  • Mediators Inflamm. 2016, 2016:6189590
  • Asian J Beauty Cosmetol2021, 19(1): 57-64.
  • Antioxidants2022, 11(2),234.
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • Evid Based Complement Alternat Med.2021, 2021:5319584.
  • Agronomy 2021, 11(3),502.
  • VNU J of Science: Med.&Pharm. Sci.2023, 39(1):20-29.
  • Pharm Biol.2016, 54(7):1255-62
  • Int. J. Mol. Sci.2022, 23(19), 11900.
  • J Pharm Biomed Anal.2019, 164:119-127
  • World J Mens Health.2019, 10.5534
  • Translational Neuroscience2024, 15:20220339
  • Green Chemistry2021, ISSUE 2.
  • BioRxiv-The Preprint server for biology2023, 586957.
  • Life Sci.2018, 209:498-506
  • ...
    • 生物活性
    Description: Trifloroside is a bitter iridoid glycoside.
    In vivo:
    J Ethnopharmacol. 2015 Aug 22;172:219-26.
    A bitter herbal medicine Gentiana scabra root extract stimulates glucagon-like peptide-1 secretion and regulates blood glucose in db/db mouse.[Pubmed: 26129938 ]
    Gentiana scabra root extract (GS) is frequently prescribed as an internal remedy in traditional Korean medicine for treatment of diabetes mellitus. GS contains bitter iridoid glycosides including loganic acid, gentiopicrin, trifloroside, and rindoside. We previously reported that the intestinal bitter taste sensation stimulates GLP-1 secretion, and thereupon hypothesized that the blood glucose regulatory effect of GS is due to its GLP-1 secreting effect in enteroendocrine L cells.
    METHODS AND RESULTS:
    We studied GLP-1 secreting effect of GS treatment and its cellular downstream mechanism in human enteroendocrine NCI-H716 cells using the G protein-coupled receptor (GPCR) pathway inhibitors. Intracellular calcium assay also demonstrated the signal transduction pathway stimulated by the GS treatment. Using db/db mice, we performed oral glucose tolerance test (OGTT) to examine the blood glucose lowering effect of GS administration. We also collected the mouse plasma during the OGTT to measure the GLP-1 and insulin levels. We demonstrated dose-dependent GLP-1 secreting effect of GS on the NCI-H716 cells. The GLP-1 secreting effect of GS is mediated by the G protein βγ-subunit and inositol triphosphate. Using db/db mice, we found that the effect of GS on lowering blood glucose is due to its GLP-1 secretion, and consequential insulinotropic effect. The chemical fingerprint of GS was obtained through a direct analysis in realtime mass spectrometry (DART-MS) and high-performance liquid chromatography (HPLC)/MS. Through the GLP-1 secretion study, we found that loganic acid, an iridoid glycoside, contributes to the GLP-1 secreting effect of GS.
    CONCLUSIONS:
    The findings of this study highlight the potential of exploiting the antidiabetic effect of GS on type 2 diabetes mellitus patients.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2776 mL 6.3881 mL 12.7763 mL 25.5526 mL 31.9407 mL
    5 mM 0.2555 mL 1.2776 mL 2.5553 mL 5.1105 mL 6.3881 mL
    10 mM 0.1278 mL 0.6388 mL 1.2776 mL 2.5553 mL 3.1941 mL
    50 mM 0.0256 mL 0.1278 mL 0.2555 mL 0.5111 mL 0.6388 mL
    100 mM 0.0128 mL 0.0639 mL 0.1278 mL 0.2555 mL 0.3194 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Gelidoside; Gelidoside CFN89019 128420-44-0 C35H42O21 = 798.7 10mg QQ客服：1457312923
    Trifloroside ; Trifloroside CFN96606 53823-10-2 C35H42O20 = 782.70 10mg QQ客服：2159513211
    龙胆苦苷; Gentiopicroside CFN98047 20831-76-9 C16H20O9 = 356.3 20mg QQ客服：2056216494
    6'-O-β-D-葡萄糖基龙胆苦苷; 6'-O-beta-D-Glucosylgentiopicroside CFN90678 115713-06-9 C22H30O14 = 518.47 20mg QQ客服：2056216494
    獐牙菜苷; Sweroside CFN99455 14215-86-2 C16H22O9 = 358.3 20mg QQ客服：2056216494
    6'-O-β-D-芹糖獐芽菜苷; 6'-O-beta-D-Apiofuranosylsweroside CFN90752 266678-59-5 C21H30O13 = 490.5 5mg QQ客服：2056216494
    苦龙胆脂甙; Amarogentin CFN90519 21018-84-8 C29H30O13 = 586.54 20mg QQ客服：215959384
    獐牙菜苦苷; Swertiamarin CFN99818 17388-39-5 C16H22O10 = 374.3 20mg QQ客服：2159513211
    断马钱子酸; Secologanic acid CFN95028 60077-46-5 C16H22O10 = 374.3 20mg QQ客服：2056216494
    表断马钱子甙半缩醛内酯; Epivogeloside CFN99283 118627-52-4 C17H24O10 = 388.4 5mg QQ客服：2056216494

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