| Description: |
Tribuloside has 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, it can improve behavior and BrdU immunoreactive cells of depression model rats and possess antidepressant effect.
Tribuloside exhibits antimycobacterial activity against the non-pathogenic Mycobacterium species Mycobacterium madagascariense and Mycobacterium indicus pranii, with a minimum inhibitory concentration (MIC) 5.0 mg/mL. |
| Targets: |
Antifection |
| In vitro: |
| Nat Prod Res. 2014;28(6):351-8. | | A new cinnamoylglycoflavonoid, antimycobacterial and antioxidant constituents from Heritiera littoralis leaf extracts.[Pubmed: 24443810] | A new cinnamolyglycoflavonoid 3-cinnamoylTribuloside (1), its precursor Tribuloside and two known flavonoid glycosides afzelin and astilbin were isolated from Heritiera littoralis Dryand (Sterculiaceae) ethanolic leaf extract.
METHODS AND RESULTS:
The dichloromethane leaf extract afforded two known pentacyclic triterpenoids, 3β-taraxerol and friedelin. Extracts and compounds isolated therefrom, with the exception of 3β-taraxerol, exhibited antimycobacterial activity against the non-pathogenic Mycobacterium species Mycobacterium madagascariense and Mycobacterium indicus pranii, with a minimum inhibitory concentration (MIC) 5.0 mg/mL for the crude extracts and MICs in the range of 1.6-0.8 mg/mL for the pure compounds. The extracts together with 3-cinnamoylTribuloside (1), Tribuloside and astilbin exhibited 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity.
CONCLUSIONS:
The compounds that showed dual activities could be further evaluated under clinical settings for co-administration with standard anti-tuberculosis drugs. |
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| In vivo: |
| Acta Chinese Medicine & Pharmacology,2008,36(3) :13-16. | | Effect of tribuloside on geurogenesis in dentate gyrus of chronic stress depression rats.[Reference: WebLink] | To observe the effect of Tribuloside on behavior and geurogenesis in dentate gyrus of chronic stress depression rats.
METHODS AND RESULTS:
All rats except the control group were singly housed and exposed an unpredicted sequence of mild stressor.The behavior of rats was detected by open-field test.And geurogenesis in dentate gyrus was observed by the Bromodeoxyuridine labelling method. Compared with control group,the weight of rats in model group showed significantly decreased(41.00±11.43g).Squares crossed(17.00±9.04),rears(6.90±4.75),and grooming(4.56±1.71s)in open-field test reduced,while time of staying in central square(4.38±0.92s)and defecation(9.34±3.01)were increased.And fluoxetine or Tribuloside significantly improve behavioral disorder and BrdU immunoreactive cells(no.1 Tribuloside group 10.23±3.81;no.2Tribuloside group 10.92±2.16;fluoxetine group 11.46±2.94).
CONCLUSIONS:
Tribuloside can improve behavior and BrdU immunoreactive cells of depression model rats and possess antidepressant effect. |
|
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)
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