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  • 三叶海棠素

    Toringin

    三叶海棠素
    产品编号 CFN93126
    CAS编号 1329-10-8
    分子式 = 分子量 C21H20O9 = 416.38
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Malus spectabilis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    三叶海棠素 CFN93126 1329-10-8 1mg QQ客服:1457312923
    三叶海棠素 CFN93126 1329-10-8 5mg QQ客服:1457312923
    三叶海棠素 CFN93126 1329-10-8 10mg QQ客服:1457312923
    三叶海棠素 CFN93126 1329-10-8 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Almansora University (Egypt)
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  • Kitasato University (Japan)
  • Uniwersytet Gdański (Poland)
  • Weizmann Institute of Science (Israel)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean Herb. Med. Inf.2021, 9(2):231-239.
  • Nutrients.2018, 10(7)
  • Int J Mol Sci.2023, 24(8):7045.
  • Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.
  • Korean J Dent Mater.2018, 45(2):139-146
  • Toxins (Basel).2023, 15(3):231.
  • Journal of Natural Remedies2024, 24(3):555–575.
  • J Phys Chem Lett.2021, 12(7):1793-1802.
  • Journal of Functional Foods2022, 96: 105216.
  • Universitat Stuttgart2022, opus-12200.
  • LWT2021, 138:110630.
  • Mol Pharmacol.2021, 99(2):163-174.
  • Phytomedicine.2022, 110:154597.
  • Front Immunol.2023, 14:1240800.
  • J Pharm Biomed Anal.2017, 140:274-280
  • Drug Chem Toxicol.2020, 1-12.
  • Phytother Res.2019, 33(4):1104-1113
  • Antioxidants (Basel).2023, 12(12):2078.
  • Molecules.2020, 25(7):1625.
  • RSC Advances2017, 86
  • Phytomedicine.2022, 102:154183.
  • Int. Conference on Med. Sci. and Bio.2017, 17973
  • Molecules.2021, 26(13):4081.
  • ...
  • 生物活性
    Description: Toringin prevents the cis-effect of expanded CTG repeats in a stable PC12 cell transformant.
    Targets: Caspase
    In vitro:
    Biochem Pharmacol. 2005 Feb 1;69(3):503-16.
    Some flavonoids and DHEA-S prevent the cis-effect of expanded CTG repeats in a stable PC12 cell transformant.[Pubmed: 15652241]
    Expanded CUG triplet repeats carrying mRNA seem to be responsible for myotonic dystrophy type 1 (DM1). To study the pathogenesis of DM1, we constructed a DM1 cell culture model using a PC12 neuronal cell line and screened flavonoids that ameliorate this mRNA gain of function.
    METHODS AND RESULTS:
    The expanded 250 CTG repeat was subcloned into the 3'-untranslated region of the luciferase gene yielding a stable transformant of PC12 (CTG-250). The cytotoxicity of CTG-250 was evaluated by intracellular LDH activity, and the cis-effect by luciferase activity. To find agents that alter CTG-250 toxic effects, 235 bioflavonoids were screened. An increased cis-effect and cytotoxicity were found when CTG-250 was treated with nerve growth factor to induce differentiation. Western blotting with anti-caspase-3 antibody suggested that cell death was caused by apoptosis. Screening analysis confirmed that a flavone (Toringin), an isoflavones (genistein and formononetin), a flavanone (isosakuranetin), and DHEA-S prevent both the cytotoxicity and cis-effect of CTG-250 and that a flavanone (naringenin), isoflavone (ononin), and xanthylatin strongly inhibit the cis-effect of CTG repeats.
    CONCLUSIONS:
    In conclusion, we found that this neuronal cell line, which expresses the CUG repeat-bearing mRNA, showed cis-effects through the reporter gene and neuronal death after cell differentiation in vitro. However, some flavonoids and DHEA-S inhibit both the cis-effect and cytotoxicity, indicating that their chemical structures work to ameliorate both these toxic effects. This system makes it easy to evaluate the toxic effects of expanded CTG repeats and therefore should be useful for screening other DM1 treatments for their efficacies.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4017 mL 12.0083 mL 24.0165 mL 48.033 mL 60.0413 mL
    5 mM 0.4803 mL 2.4017 mL 4.8033 mL 9.6066 mL 12.0083 mL
    10 mM 0.2402 mL 1.2008 mL 2.4017 mL 4.8033 mL 6.0041 mL
    50 mM 0.048 mL 0.2402 mL 0.4803 mL 0.9607 mL 1.2008 mL
    100 mM 0.024 mL 0.1201 mL 0.2402 mL 0.4803 mL 0.6004 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灯盏花苷 I; Erigeside I CFN96865 224824-74-2 C20H20O11 = 436.36 5mg QQ客服:1413575084
    环(酪氨酸-脯氨酸)二肽; Cyclo(Tyr-Pro) CFN90276 5654-84-2 C14H16N2O3 = 260.29 10mg QQ客服:2056216494
    5,7,3',4'-四甲氧基黄酮; 5,7,3',4'-Tetramethoxyflavone CFN91116 855-97-0 C19H18O6 = 342.3 20mg QQ客服:2159513211
    表大戟二烯醇; Tirucallol CFN89512 514-46-5 C30H50O = 426.71 5mg QQ客服:2056216494

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