Info: Read More
    		•
  • 中药标准品生产商，产品定制服务
    		•
  • 首页
  • 天然产物
  • 产品文献
  • 最新产品
  • 订购流程
  • 公司新闻
  • 公司简介
  • 联系我们
  • 首页
  • /
  • 天然产物（标准品）
  • /
  • Tilifodiolide

    • Tilifodiolide

    Tilifodiolide

    Tilifodiolide
    		产品编号 CFN99378
    CAS编号 126724-95-6
    分子式 = 分子量 C20H16O5 = 336.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The herbs of Salvia tiliaefolia
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Tilifodiolide CFN99378 126724-95-6 1mg QQ客服：215959384
    Tilifodiolide CFN99378 126724-95-6 5mg QQ客服：215959384
    Tilifodiolide CFN99378 126724-95-6 10mg QQ客服：215959384
    Tilifodiolide CFN99378 126724-95-6 20mg QQ客服：215959384
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

    2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。 但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常，这些可用于长达两周。 使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度，使用和处理的建议？ 请发送电子邮件至：service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话：
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到：027-84254680

    • 提供订购信息
  • 为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号（CAS No.或产品名称）
  • 2. 发货地址
  • 3. 联系方法 (联系人，电话）
  • 4. 开票抬头 (如果需要发票的客户）
  • 5. 发票地址（发货地址与发票地址不同）
    • 发货时间
    1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Universidade do Porto (Portugal)
  • Max Rubner-Institut (MRI) (Germany)
  • Chungnam National University (Korea)
  • University of East Anglia (United Kingdom)
  • Medical University of South Carolina (USA)
  • Istanbul University (Turkey)
  • Korea Food Research Institute(KFRI) (Korea)
  • Helmholtz Zentrum München (Germany)
  • Melbourne University (Australia)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • University of South Australia (Australia)
  • Massachusetts General Hospital (USA)
  • Technical University of Denmark (Denmark)
  • Worcester Polytechnic Institute (USA)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Vietnam Journal of Food Control2022, 5(3):pp.390-401.
  • ACS Nano.2018, 12(4):3385-3396
  • Food Chem Toxicol.2020, 135:110863
  • Biosci Biotechnol Biochem.2021, 85(10):2153-2160.
  • Iranian J. Pharm. Res.2021, 20(4):59-70
  • Biomedicines.2022, 10(3):583.
  • Biomed Sci Letters.2020, 26:319-326
  • Current Traditional Medicine, 2021, 7:326-335(10).
  • Pharmaceuticals (Basel).2021, 14(3):260.
  • Molecules.2022, 27(22):7997.
  • Food Chemistry2023, 137837.
  • Horticulturae2023, 9(2), 213.
  • Cells.2022, 11(6):931.
  • Int J Mol Med.2015, 35(5):1237-45
  • BMC Complement Altern Med.2017, 17(1):384
  • BMC Plant Biol.2020, 20(1):214.
  • J Pharm Biomed Anal.2019, 172:268-277
  • Planta Med.2018, 84(15):1101-1109
  • RSC Advances2017, 86
  • J Chromatogr Sci.2015, 53(5):824-9
  • Anal Chim Acta.2021, 1180:338874.
  • Molecular & Cellular Toxicology2022, 10.1007:s13273-022-00277-3
  • ACS Synth Biol.2020, 9(9):2282-2290.
  • ...
    • 生物活性
    Description: Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreasing the intestinal fluid accumulation and vasorelaxant effects mediated by nitric oxide and cyclic guanosine monophosphate, it also showed anxiolytic and antidepressant effects by the partial involvement of gamma-Aminobutyric acid (GABA) receptors and the possible participation of α2-adrenoreceptors, respectively.
    Targets: TNF-α | IL-6 | GABA Receptor
    In vivo:
    Drug Development Research, 2018, 79(4):165.
    Anti-inflammatory and antinociceptive effects of tilifodiolide, isolated from Salvia tiliifolia Vahl (Lamiaceae).[Reference: WebLink]
    Salvia tiliifolia Vahl (Lamiaceae) is used for the empirical treatment of pain and inflammation. The diterpenoid tilifodiolide (TFD) was isolated from Salvia tiliifolia.
    METHODS AND RESULTS:
    The in vitro anti-inflammatory effects of TFD (0.1-200 µM) were assessed using murine macrophages stimulated with LPS and estimating the levels of pro-inflammatory mediators for 48 h. The in vivo anti-inflammatory activity of TFD was assessed using the carrageenan-induced paw edema test for 6 h. The antinociceptive effects of TFD were evaluated using the formalin test and the acetic acid induced-writhing test. The effects of TFD on locomotor activity were assessed using the open field test and the rotarod test. TFD inhibited the production of TNF-α (IC50  = 5.66 µM) and IL-6 (IC50  = 1.21 µM) in macrophages. TFD (200 mg/kg) showed anti-inflammatory effects with similar activity compared to 10 mg/kg indomethacin. The administration of TFD induced antinociception in the phase 1 (ED50  = 48.2 mg/kg) and the phase 2 (ED50  = 28.9 mg/kg) of the formalin test. In the acetic acid assay, TFD showed antinociceptive effects (ED50  = 32.3 mg/kg) with similar potency compared to naproxen (ED50  = 36.2 mg/kg).
    CONCLUSIONS:
    In the presence of different inhibitors in the acetic acid assay, only the co-administration of TFD and naloxone reverted the antinociceptive activity shown by TFD alone. TFD did not affect locomotor activity in mice. TFD exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9735 mL 14.8677 mL 29.7354 mL 59.4707 mL 74.3384 mL
    5 mM 0.5947 mL 2.9735 mL 5.9471 mL 11.8941 mL 14.8677 mL
    10 mM 0.2974 mL 1.4868 mL 2.9735 mL 5.9471 mL 7.4338 mL
    50 mM 0.0595 mL 0.2974 mL 0.5947 mL 1.1894 mL 1.4868 mL
    100 mM 0.0297 mL 0.1487 mL 0.2974 mL 0.5947 mL 0.7434 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Borapetoside B; Borapetoside B CFN96298 104901-05-5 C27H36O12 = 552.6 5mg QQ客服：1413575084
    Dehydroborapetoside B; Dehydroborapetoside B CFN96306 1221178-16-0 C27H34O12 = 550.6 5mg QQ客服：215959384
    Borapetoside F; Borapetoside F CFN96279 151200-50-9 C27H34O11 = 534.6 5mg QQ客服：215959384
    Borapetoside E; Borapetoside E CFN96274 151200-49-6 C27H36O11 = 536.6 10mg QQ客服：3257982914
    Borapetoside D; Borapetoside D CFN96317 151200-48-5 C33H46O16 = 698.7 5mg QQ客服：1457312923
    黄独素C; Diosbulbin C CFN98015 20086-07-1 C19H22O7 = 362.4 5mg QQ客服：215959384
    黄独素B； 黄独乙素； 黄药子素B; Diosbulbin B CFN98014 20086-06-0 C19H20O6 = 344.4 20mg QQ客服：215959384
    Methyl-Dodovisate A; Methyl-Dodovisate A CFN97837 1246937-33-6 C21H26O3 = 326.43 5mg QQ客服：1413575084
    Isosalvipuberulin; Isosalvipuberulin CFN99251 115321-32-9 C20H14O5 = 334.3 5mg QQ客服：215959384
    Tilifodiolide; Tilifodiolide CFN99378 126724-95-6 C20H16O5 = 336.3 5mg QQ客服：215959384

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

    联系方式


    电机：027-84237783
    传真：027-84254680
    在线QQ: 1413575084
    E-Mail：manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。