Tilifodiolide

	产品编号	CFN99378
	CAS编号	126724-95-6
	分子式 = 分子量	C₂₀H₁₆O₅ = 336.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The herbs of Salvia tiliaefolia
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Tilifodiolide	CFN99378	126724-95-6	1mg	QQ客服：1413575084
Tilifodiolide	CFN99378	126724-95-6	5mg	QQ客服：1413575084
Tilifodiolide	CFN99378	126724-95-6	10mg	QQ客服：1413575084
Tilifodiolide	CFN99378	126724-95-6	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Shanghai Institute of Biochemistry and Cell Biology (China)

Siksha O Anusandhan University (India)

Universidad de La Salle (Mexico)

Max Rubner-Institut (MRI) (Germany)

Florida International University (USA)

Celltrion Chemical Research Institute (Korea)

Monash University Sunway Campus (Malaysia)

Universidade de Franca (Brazil)

Instituto Politécnico de Bragan?a (Portugal)

Utrecht University (Netherlands)

University of Oslo (Norway)

Hamdard University (India)

Istanbul University (Turkey)

University of Illinois at Chicago (USA)

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Description:

Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreasing the intestinal fluid accumulation and vasorelaxant effects mediated by nitric oxide and cyclic guanosine monophosphate, it also showed anxiolytic and antidepressant effects by the partial involvement of gamma-Aminobutyric acid (GABA) receptors and the possible participation of α2-adrenoreceptors, respectively.

Targets:

TNF-α | IL-6 | GABA Receptor

In vivo:

Drug Development Research, 2018, 79(4):165.

Anti-inflammatory and antinociceptive effects of tilifodiolide, isolated from Salvia tiliifolia Vahl (Lamiaceae).[Reference: WebLink]

Salvia tiliifolia Vahl (Lamiaceae) is used for the empirical treatment of pain and inflammation. The diterpenoid tilifodiolide (TFD) was isolated from Salvia tiliifolia.
METHODS AND RESULTS:
The in vitro anti-inflammatory effects of TFD (0.1-200 µM) were assessed using murine macrophages stimulated with LPS and estimating the levels of pro-inflammatory mediators for 48 h. The in vivo anti-inflammatory activity of TFD was assessed using the carrageenan-induced paw edema test for 6 h. The antinociceptive effects of TFD were evaluated using the formalin test and the acetic acid induced-writhing test. The effects of TFD on locomotor activity were assessed using the open field test and the rotarod test. TFD inhibited the production of TNF-α (IC50 = 5.66 µM) and IL-6 (IC50 = 1.21 µM) in macrophages. TFD (200 mg/kg) showed anti-inflammatory effects with similar activity compared to 10 mg/kg indomethacin. The administration of TFD induced antinociception in the phase 1 (ED50 = 48.2 mg/kg) and the phase 2 (ED50 = 28.9 mg/kg) of the formalin test. In the acetic acid assay, TFD showed antinociceptive effects (ED50 = 32.3 mg/kg) with similar potency compared to naproxen (ED50 = 36.2 mg/kg).
CONCLUSIONS:
In the presence of different inhibitors in the acetic acid assay, only the co-administration of TFD and naloxone reverted the antinociceptive activity shown by TFD alone. TFD did not affect locomotor activity in mice. TFD exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
黄独素I; Diosbulbin I	CFN99288	1187951-05-8	C₂₉H₃₀O₈ = 506.6	5mg	QQ客服：2056216494
黄独素 L; Diosbulbin L	CFN89003	1236285-87-2	C₁₉H₂₂O₇ = 362.37	5mg	QQ客服：2056216494
黄独素J; Diosbulbin J	CFN99289	1187951-06-9	C₁₉H₂₂O₈ = 378.4	5mg	QQ客服：215959384
Borapetoside A; Borapetoside A	CFN95658	100202-29-7	C₂₆H₃₄O₁₂ = 538.6	10mg	QQ客服：1413575084
Borapetoside B; Borapetoside B	CFN96298	104901-05-5	C₂₇H₃₆O₁₂ = 552.6	5mg	QQ客服：3257982914
Dehydroborapetoside B; Dehydroborapetoside B	CFN96306	1221178-16-0	C₂₇H₃₄O₁₂ = 550.6	5mg	QQ客服：1413575084
Borapetoside F; Borapetoside F	CFN96279	151200-50-9	C₂₇H₃₄O₁₁ = 534.6	5mg	QQ客服：2159513211
Borapetoside E; Borapetoside E	CFN96274	151200-49-6	C₂₇H₃₆O₁₁ = 536.6	10mg	QQ客服：2159513211
Borapetoside D; Borapetoside D	CFN96317	151200-48-5	C₃₃H₄₆O₁₆ = 698.7	5mg	QQ客服：215959384
黄独素C; Diosbulbin C	CFN98015	20086-07-1	C₁₉H₂₂O₇ = 362.4	5mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9735 mL	14.8677 mL	29.7354 mL	59.4707 mL	74.3384 mL
5 mM	0.5947 mL	2.9735 mL	5.9471 mL	11.8941 mL	14.8677 mL
10 mM	0.2974 mL	1.4868 mL	2.9735 mL	5.9471 mL	7.4338 mL
50 mM	0.0595 mL	0.2974 mL	0.5947 mL	1.1894 mL	1.4868 mL
100 mM	0.0297 mL	0.1487 mL	0.2974 mL	0.5947 mL	0.7434 mL