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  • 巴豆酰戈米辛 H

    • 巴豆酰戈米辛 H

    Tigloylgomisin H

    巴豆酰戈米辛 H
    		产品编号 CFN96618
    CAS编号 66069-55-4
    分子式 = 分子量 C28H36O8 = 500.59
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The fruits of Schisandra chinensis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    巴豆酰戈米辛 H CFN96618 66069-55-4 1mg QQ客服：3257982914
    巴豆酰戈米辛 H CFN96618 66069-55-4 5mg QQ客服：3257982914
    巴豆酰戈米辛 H CFN96618 66069-55-4 10mg QQ客服：3257982914
    巴豆酰戈米辛 H CFN96618 66069-55-4 20mg QQ客服：3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • LWT2024, 200:116184.
  • Tumour Biol.2015, 36(9):7027-34
  • J Microbiol Biotechnol.2020, 30(2):178-186.
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Evid Based Complement Alternat Med.2022, 9767292,2.
  • LWT2020, 110397
  • J Ethnopharmacol.2019, 228:132-141
  • Curr Top Med Chem.2020, 20(21):1898-1909.
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  • Environ Toxicol.2021, 36(9):1848-1856.
  • Mol Med Rep.2014, 9(5):1653-9
  • Mol Plant Pathol.2022, 10.1111:mpp.13280.
  • Molecules.2017, 22(3)
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • Molecules2022, 27(9):2827.
  • Advances in Traditional Medicine 2021, 21:779-789.
  • Integr Med Res.2017, 6(4):395-403
  • Phytomedicine.2023, 117:154929.
  • J Sep Sci.2019, 42(21):3352-3362
  • Evid Based Complement Alternat Med.2020, 2020:1970349.
  • Pharmacognosy Magazine2018, 14(56):418-424
  • Pharmacognosy Journal2019, 11(2): 369-373
  • ...
    • 生物活性
    Description: Tigloylgomisin H represents a potential liver cancer prevention agent, it can significantly induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells, it functions as a novel monofunctional inducer that specifically upregulates phase II enzymes through the Nrf2-ARE pathway.
    Targets: Nrf2 | ARE
    In vitro:
    Planta Med. 2009 Oct;75(12):1314-8.
    Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2.[Pubmed: 19452436]
    The upregulation of phase II detoxification genes is believed to play an important role in cancer prevention. The molecular mechanism underlying the changes in gene expression that accompany cancer prevention involves activation of the transcription factor, NF-E2-related factor 2 (Nrf2). In traditional medicine, the fruit of Schisandra chinensis Baill is used as a tonic, an anti-tussive and an anti-aging drug.
    METHODS AND RESULTS:
    In the current study, nine lignans were isolated from S. chinensis and tested for their ability to induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H (TGH) and angeloylgomisin H (AGH) significantly induced QR activity and exhibited a relatively high chemoprevention index (CI) (10.80 and 4.59, respectively) as compared to control. TGH also induced QR activity in BPrc1 mouse hepatocarcinoma cells as well, which are defective in aryl hydrocarbon nuclear translocator (Arnt). In HepG2 human hepatocarcinoma cells, TGH significantly activated gene expression mediated by the antioxidant response element (ARE), a key regulatory region in the promoters of detoxification enzymes, through the nuclear accumulation of Nrf2.
    CONCLUSIONS:
    The results of the current study suggest that TGH functions as a novel monofunctional inducer that specifically upregulates phase II enzymes through the Nrf2-ARE pathway. TGH thus represents a potential liver cancer prevention agent.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9976 mL 9.9882 mL 19.9764 mL 39.9529 mL 49.9411 mL
    5 mM 0.3995 mL 1.9976 mL 3.9953 mL 7.9906 mL 9.9882 mL
    10 mM 0.1998 mL 0.9988 mL 1.9976 mL 3.9953 mL 4.9941 mL
    50 mM 0.04 mL 0.1998 mL 0.3995 mL 0.7991 mL 0.9988 mL
    100 mM 0.02 mL 0.0999 mL 0.1998 mL 0.3995 mL 0.4994 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    五味子酯乙; Schisantherin B CFN99924 58546-55-7 C28H34O9 = 514.57 20mg QQ客服：2159513211
    五味子酯甲; Schisantherin A CFN99925 58546-56-8 C30H32O9 = 536.56 20mg QQ客服：2159513211
    戈米辛D; Gomisin D CFN90122 60546-10-3 C28H34O10 = 530.56 20mg QQ客服：1413575084
    戈米辛 E; Gomisin E CFN96725 72960-21-5 C28H34O9 = 514.57 5mg QQ客服：1413575084
    戈米辛F; Gomisin F CFN92719 62956-47-2 C28H34O9 = 514.6 5mg QQ客服：2159513211
    戈米辛G; Gomisin G CFN90123 62956-48-3 C30H32O9 = 536.6 10mg QQ客服：1457312923
    戈米辛H; Gomisin H CFN94008 66056-20-0 C23H30O7 = 418.5 10mg QQ客服：1457312923
    巴豆酰戈米辛 H; Tigloylgomisin H CFN96618 66069-55-4 C28H36O8 = 500.59 5mg QQ客服：2159513211
    苯甲酰戈米辛 H; Benzoylgomisin H CFN96939 66056-23-3 C30H34O8 = 522.59 5mg QQ客服：1413575084
    Schisphenin E ; Schisphenin E CFN95223 1311376-52-9 C24H32O7 = 432.5 5mg QQ客服：2056216494

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