巴豆酰戈米辛 H

Tigloylgomisin H

	产品编号	CFN96618
	CAS编号	66069-55-4
	分子式 = 分子量	C₂₈H₃₆O₈ = 500.59
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Lignans
	植物来源	The fruits of Schisandra chinensis.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
巴豆酰戈米辛 H	CFN96618	66069-55-4	1mg	QQ客服：1457312923
巴豆酰戈米辛 H	CFN96618	66069-55-4	5mg	QQ客服：1457312923
巴豆酰戈米辛 H	CFN96618	66069-55-4	10mg	QQ客服：1457312923
巴豆酰戈米辛 H	CFN96618	66069-55-4	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Helsinki (Finland)

Aveiro University (Portugal)

National Research Council of Canada (Canada)

University of South Australia (Australia)

Institute of Chinese Materia Medica (China)

Universidade da Beira Interior (Germany)

Almansora University (Egypt)

Korea Intitute of Science and Technology (KIST) (Korea)

Universitas islam negeri Jakarta (Indonesia)

Medizinische Universit?t Wien (Austria)

Uniwersytet Medyczny w ?odzi (Poland)

Cancer Research Initatives Foundation(CARIF) (Malaysia)

University of Toulouse (France)

Agricultural Research Organization (ARO) (Israel)

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Description:

Tigloylgomisin H represents a potential liver cancer prevention agent, it can significantly induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells, it functions as a novel monofunctional inducer that specifically upregulates phase II enzymes through the Nrf2-ARE pathway.

Targets:

Nrf2 | ARE

In vitro:

Planta Med. 2009 Oct;75(12):1314-8.

Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2.[Pubmed: 19452436]

The upregulation of phase II detoxification genes is believed to play an important role in cancer prevention. The molecular mechanism underlying the changes in gene expression that accompany cancer prevention involves activation of the transcription factor, NF-E2-related factor 2 (Nrf2). In traditional medicine, the fruit of Schisandra chinensis Baill is used as a tonic, an anti-tussive and an anti-aging drug.
METHODS AND RESULTS:
In the current study, nine lignans were isolated from S. chinensis and tested for their ability to induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H (TGH) and angeloylgomisin H (AGH) significantly induced QR activity and exhibited a relatively high chemoprevention index (CI) (10.80 and 4.59, respectively) as compared to control. TGH also induced QR activity in BPrc1 mouse hepatocarcinoma cells as well, which are defective in aryl hydrocarbon nuclear translocator (Arnt). In HepG2 human hepatocarcinoma cells, TGH significantly activated gene expression mediated by the antioxidant response element (ARE), a key regulatory region in the promoters of detoxification enzymes, through the nuclear accumulation of Nrf2.
CONCLUSIONS:
The results of the current study suggest that TGH functions as a novel monofunctional inducer that specifically upregulates phase II enzymes through the Nrf2-ARE pathway. TGH thus represents a potential liver cancer prevention agent.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
戈米辛O; Gomisin O	CFN90751	72960-22-6	C₂₃H₂₈O₇ = 416.46	10mg	QQ客服：2056216494
当归酰基戈米辛 O; Angeloylgomisin O	CFN89067	83864-69-1	C₂₈H₃₄O₈ = 498.57	10mg	QQ客服：3257982914
鹤庆五味子癸素; Schisanwilsonin I	CFN98732	1181216-84-1	C₂₈H₃₄O₉ = 514.6	5mg	QQ客服：2056216494
内南五味子酯 C; Interiotherin C	CFN92730	460090-65-7	C₃₀H₃₆O₁₀ = 556.6	5mg	QQ客服：1457312923
滇藏五味子素G; Negsehisandrin G	CFN90533	1023744-69-5	C₂₈H₃₆O₇ = 484.6	10mg	QQ客服：215959384
五味子酯乙; Schisantherin B	CFN99924	58546-55-7	C₂₈H₃₄O₉ = 514.57	20mg	QQ客服：215959384
五味子酯甲; Schisantherin A	CFN99925	58546-56-8	C₃₀H₃₂O₉ = 536.56	20mg	QQ客服：3257982914
戈米辛D; Gomisin D	CFN90122	60546-10-3	C₂₈H₃₄O₁₀ = 530.56	20mg	QQ客服：2159513211
戈米辛 E; Gomisin E	CFN96725	72960-21-5	C₂₈H₃₄O₉ = 514.57	5mg	QQ客服：1457312923
戈米辛F; Gomisin F	CFN92719	62956-47-2	C₂₈H₃₄O₉ = 514.6	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9976 mL	9.9882 mL	19.9764 mL	39.9529 mL	49.9411 mL
5 mM	0.3995 mL	1.9976 mL	3.9953 mL	7.9906 mL	9.9882 mL
10 mM	0.1998 mL	0.9988 mL	1.9976 mL	3.9953 mL	4.9941 mL
50 mM	0.04 mL	0.1998 mL	0.3995 mL	0.7991 mL	0.9988 mL
100 mM	0.02 mL	0.0999 mL	0.1998 mL	0.3995 mL	0.4994 mL