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  • 胸腺嘧啶

    Thymine

    胸腺嘧啶
    产品编号 CFN70183
    CAS编号 65-71-4
    分子式 = 分子量 C5H6N2O2 = 126.1
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    胸腺嘧啶 CFN70183 65-71-4 10mg QQ客服:1457312923
    胸腺嘧啶 CFN70183 65-71-4 20mg QQ客服:1457312923
    胸腺嘧啶 CFN70183 65-71-4 50mg QQ客服:1457312923
    胸腺嘧啶 CFN70183 65-71-4 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Dicle (Turkey)
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  • Shanghai University of TCM (China)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Plant Biol.2020, 20(1):214.
  • J Chromatogr A.2017, 1518:46-58
  • Horticulturae2023, 9(2), 213.
  • Molecules.2024, 29(5):1050.
  • Front Pharmacol.2017, 8:673
  • Regul Toxicol Pharmacol.2024, 149:105620.
  • J Integr Plant Biol.2023, 13564.
  • Int J Mol Sci.2022, 23(20):12516.
  • Pak J Pharm Sci.2019, 32(6)
  • In Vitro Cellular & Developmental Biology - Plant 2021, 57:874–882.
  • Tokyo Pharmaceutical University2020, 500001431953.
  • Res Rep Urol.2022, 14:313-326.
  • Sains Malaysiana2022, 51(4):1143-1154
  • Cell Physiol Biochem.2019, 52(6):1255-1266
  • Institute of Food Science & Technology2021, 45(9).
  • Molecules.2015, 20(10):19172-88
  • Front Plant Sci.2017, 8:723
  • J Ethnopharmacol.2020, 254:112733.
  • Talanta Open2023, 7:100227
  • Phytomedicine.2019, 57:95-104
  • Pest Manag Sci.2019, 75(9):2530-2541
  • Int. J. Mol. Sci. 2022, 23(3),1696.
  • Universidade Estadual Paulista2017, 42785
  • ...
  • 生物活性
    Description: Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair.
    In vitro:
    Biochemistry, 1989, 28(20):7979-84.
    A new mechanism for repairing oxidative damage to DNA: (A)BC excinuclease removes AP sites and thymine glycols from DNA.[Reference: WebLink]
    Escherichia coli (A)BC excinuclease is the major enzyme responsible for removing bulky adducts, such as pyrimidine dimers and 6-4 photoproducts, from DNA. Mutants deficient in this enzyme are extremely sensitive to UV and UV-mimetic agents, but not to oxidizing agents, or ionizing radiation which damages DNA in part by generating active oxygen species. DNA glycosylases and AP1 endonucleases play major roles in repairing oxidative DNA damage, and thus it has been assumed that nucleotide excision repair has no role in cellular defense against damage by ionizing radiation and oxidative damage.
    METHODS AND RESULTS:
    In this study we show that the E. coli nucleotide excision repair enzyme (A)BC excinuclease removes from DNA the two major products of oxidative damage, thymine glycol and the baseless sugar (AP site).
    CONCLUSIONS:
    We conclude that nucleotide excision repair is an important cellular defense mechanism against oxidizing agents.
    Proceedings of the National Academy of Sciences of the United States of America, 01 Aug 1989, 86(16):6196-6200
    Dynamics of mitochondrial DNA evolution in animals: amplification and sequencing with conserved primers.[Reference: WebLink]

    METHODS AND RESULTS:
    With a standard set of primers directed toward conserved regions, we have used the polymerase chain reaction to amplify homologous segments of mtDNA from more than 100 animal species, including mammals, birds, amphibians, fishes, and some invertebrates. Amplification and direct sequencing were possible using unpurified mtDNA from nanogram samples of fresh specimens and microgram amounts of tissues preserved for months in alcohol or decades in the dry state. The bird and fish sequences evolve with the same strong bias toward transitions that holds for mammals. However, because the light strand of birds is deficient in thymine, thymine to cytosine transitions are less common than in other taxa. Amino acid replacement in a segment of the cytochrome b gene is faster in mammals and birds than in fishes and the pattern of replacements fits the structural hypothesis for cytochrome b.
    CONCLUSIONS:
    The unexpectedly wide taxonomic utility of these primers offers opportunities for phylogenetic and population research.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 7.9302 mL 39.6511 mL 79.3021 mL 158.6043 mL 198.2554 mL
    5 mM 1.586 mL 7.9302 mL 15.8604 mL 31.7209 mL 39.6511 mL
    10 mM 0.793 mL 3.9651 mL 7.9302 mL 15.8604 mL 19.8255 mL
    50 mM 0.1586 mL 0.793 mL 1.586 mL 3.1721 mL 3.9651 mL
    100 mM 0.0793 mL 0.3965 mL 0.793 mL 1.586 mL 1.9826 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    15-甲氧基松柏酸; 15-Methoxypinusolidic acid CFN97253 769928-72-5 C21H30O5 = 362.5 5mg QQ客服:2159513211
    3-羟基-4-甲氧基肉桂酸; 3-Hydroxy-4-methoxycinnamic acid CFN99135 537-73-5 C10H10O4 = 194.18 20mg QQ客服:3257982914
    5-甲氧基莨菪亭; Umckalin CFN70362 43053-62-9 C11H10O5 = 222.2 5mg QQ客服:2056216494
    维莫德吉; Vismodegib (GDC-0449) CFN60226 879085-55-9 C19H14Cl2N2O3S = 421.3 5mg QQ客服:2159513211

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