3,3',4,4'-四羟基-2-甲氧基查尔酮

Tetrahydroxymethoxychalcone

	产品编号	CFN91674
	CAS编号	197227-39-7
	分子式 = 分子量	C₁₆H₁₄O₆ = 302.28
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Chalcones
	植物来源	The fruits of Alpinia katsumadai
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
3,3',4,4'-四羟基-2-甲氧基查尔酮	CFN91674	197227-39-7	1mg	QQ客服：3257982914
3,3',4,4'-四羟基-2-甲氧基查尔酮	CFN91674	197227-39-7	5mg	QQ客服：3257982914
3,3',4,4'-四羟基-2-甲氧基查尔酮	CFN91674	197227-39-7	10mg	QQ客服：3257982914
3,3',4,4'-四羟基-2-甲氧基查尔酮	CFN91674	197227-39-7	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

National Chung Hsing University (Taiwan)

Monash University Malaysia (Malaysia)

Technical University of Denmark (Denmark)

University of Toronto (Canada)

University of Auckland (New Zealand)

University of Medicine and Pharmacy (Romania)

Shanghai University of TCM (China)

University of Cincinnati (USA)

Helmholtz Zentrum München (Germany)

Universidad Veracuzana (Mexico)

Medical University of South Carolina (USA)

University of Fribourg (Switzerland)

Vin?a Institute of Nuclear Sciences (Serbia)

Aveiro University (Portugal)

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Description:

Tetrahydroxymethoxychalcone is a phenolic and flavonoid compound. Tetrahydroxymethoxychalcone is found to enhance myoblast proliferation and differentiation. Tetrahydroxymethoxychalcone plays important roles in myogenesis and muscle regeneration.

In vitro:

Int J Mol Sci . 2021 Jan 16;22(2):876.

Isolation and Characterization of Compounds from Glycyrrhiza uralensis as Therapeutic Agents for the Muscle Disorders[Pubmed: 33467209]

Skeletal muscle is the most abundant tissue and constitutes about 40% of total body mass. Herein, we report that crude water extract (CWE) of G. uralensis enhanced myoblast proliferation and differentiation. Pretreatment of mice with the CWE of G. uralensis prior to cardiotoxin-induced muscle injury was found to enhance muscle regeneration by inducing myogenic gene expression and downregulating myostatin expression. Furthermore, this extract reduced nitrotyrosine protein levels and atrophy-related gene expression. Of the five different fractions of the CWE of G. uralensis obtained, the ethyl acetate (EtOAc) fraction more significantly enhanced myoblast proliferation and differentiation than the other fractions. Ten bioactive compounds were isolated from the EtOAc fraction and characterized by GC-MS and NMR. Of these compounds (4-hydroxybenzoic acid, liquiritigenin, (R)-(-)-vestitol, isoliquiritigenin, medicarpin, tetrahydroxymethoxychalcone, licochalcone B, liquiritin, liquiritinapioside, and ononin), liquiritigenin, tetrahydroxymethoxychalcone, and licochalcone B were found to enhance myoblast proliferation and differentiation, and myofiber diameters in injured muscles were wider with the liquiritigenin than the non-treated one. Computational analysis showed these compounds are non-toxic and possess good drug-likeness properties. These findings suggest that G. uralensis-extracted components might be useful therapeutic agents for the management of muscle-associated diseases.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
龙血素D; Loureirin D	CFN92676	119425-91-1	C₁₆H₁₆O₅ = 288.3	10mg	QQ客服：3257982914
4,4'-二羟基-2,6-二甲氧基二氢查耳酮; 4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone	CFN91700	151752-08-8	C₁₇H₁₈O₅ = 302.3	5mg	QQ客服：1413575084
龙血素B; Loureirin B	CFN98173	119425-90-0	C₁₈H₂₀O₅ = 316.35	20mg	QQ客服：2159513211
2',4'-二氢查耳酮; 2',4'-Dihydroxydihydrochalcone	CFN70401	53596-71-7	C₁₅H₁₄O₃ = 242.3	20mg	QQ客服：3257982914
4'-羟基查耳酮; 2-Benzal-4-hydroxyacetophenone	CFN70089	2657-25-2	C₁₅H₁₂O₂ = 224.2	20mg	QQ客服：1457312923
2',4'-二羟查耳酮; 2',4'-Dihydroxychalcone	CFN95493	1776-30-3	C₁₅H₁₂O₃ = 240.3	20mg	QQ客服：1457312923
3,4-二甲氧基查耳酮; 3,4-Dimethoxychalcone	CFN70481	5416-71-7	C₁₇H₁₆O₃ = 268.3	5mg	QQ客服：2159513211
紫铆因; Butein	CFN98776	487-52-5	C₁₅H₁₂O₅ = 272.3	20mg	QQ客服：2159513211
Homobutein; Homobutein	CFN70340	34000-39-0	C₁₆H₁₄O₅ = 286.3	5mg	QQ客服：2056216494
3,2',4'-三羟基-4-甲氧基查耳酮; 4-O-Methylbutein	CFN96387	13323-67-6	C₁₆H₁₄O₅ = 286.3	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3082 mL	16.541 mL	33.0819 mL	66.1638 mL	82.7048 mL
5 mM	0.6616 mL	3.3082 mL	6.6164 mL	13.2328 mL	16.541 mL
10 mM	0.3308 mL	1.6541 mL	3.3082 mL	6.6164 mL	8.2705 mL
50 mM	0.0662 mL	0.3308 mL	0.6616 mL	1.3233 mL	1.6541 mL
100 mM	0.0331 mL	0.1654 mL	0.3308 mL	0.6616 mL	0.827 mL