塔斯品碱

Taspine

	产品编号	CFN96648
	CAS编号	602-07-3
	分子式 = 分子量	C₂₀H₁₉NO₆ = 369.37
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The herbs of Radix et Rhizoma Leonticis.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
塔斯品碱	CFN96648	602-07-3	1mg	QQ客服：215959384
塔斯品碱	CFN96648	602-07-3	5mg	QQ客服：215959384
塔斯品碱	CFN96648	602-07-3	10mg	QQ客服：215959384
塔斯品碱	CFN96648	602-07-3	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Wageningen University (Netherlands)

Centralised Purchases Unit (CPU), B.I.T.S (India)

Chiang Mai University (Thailand)

Monash University (Australia)

Chulalongkorn University (Thailand)

Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)

National Research Council of Canada (Canada)

Shanghai University of TCM (China)

Martin Luther University of Halle-Wittenberg (Germany)

University of Vigo (Spain)

Universidade da Beira Interior (Germany)

Siksha O Anusandhan University (India)

University of Cincinnati (USA)

Universitas islam negeri Jakarta (Indonesia)

More...

Description:

Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of HUVEC in a dose-dependent manner, it has shown meaningful angiogenesis activity. Taspine exhibits a dose-related cicatrizant effect and an ED50 of 0.375 mg/kg.

Targets:

In vivo:

Planta Med. 1989 Apr;55(2):140-3.

Taspine is the cicatrizant principle in Sangre de Grado extracted from Croton lechleri.[Pubmed: 2748730]

Sangre de Grado extract used by Peruvian natives as a cicatrizant agent, was collected from trees of the species Croton lechleri growing in the Peruvian jungle.
METHODS AND RESULTS:
The Sangre de Grado was found to contain one alkaloid identified as taspine and which was shown to be the active cicatrizant principle by an in vivo test in mice. This alkaloid exhibited a dose-related cicatrizant effect and an ED50 of 0.375 mg/kg. Experiments with taspine hydrochloride in order to study its mechanism of action in cell culture systems showed that the alkaloid was non-toxic to human foreskin fibroblasts at concentrations below 150 ng/ml and that it had no effect on cell proliferation. On the other hand, taspine hydrochloride was found to increase the migration of human foreskin fibroblasts. This effect on the migration of fibroblasts is probably the mechanism by which Sangre de Grado and taspine hydrochloride accelerate the wound healing process.
CONCLUSIONS:
Using the two-stage mouse skin carcinogenesis system, we have been able to show that neither Sangre de Grado nor taspine hydrochloride had carcinogenic or tumour promoter activity after 17 months of treatment.

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紫树甙; Nyssoside	CFN99851	182138-70-1	C₂₂H₁₈O₁₃ = 490.4	5mg	QQ客服：1413575084
黄芩素 6-O-葡萄糖苷; Baicalein 6-O-glucoside	CFN92361	28279-72-3	C₂₁H₂₀O₁₀ = 432.4	5mg	QQ客服：3257982914
3-O-反式对香豆酰委陵菜酸; 3-O-trans-p-Coumaroyltormentic acid	CFN97843	121064-78-6	C₃₉H₅₄O₇ = 634.86	5mg	QQ客服：1457312923
Delta-9-四氢大麻酚; Delta-9-Tetrahydrocannabinol	CFN91898	1972-08-3	C₂₁H₃₀O₂ = 314.46	5mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7073 mL	13.5366 mL	27.0731 mL	54.1462 mL	67.6828 mL
5 mM	0.5415 mL	2.7073 mL	5.4146 mL	10.8292 mL	13.5366 mL
10 mM	0.2707 mL	1.3537 mL	2.7073 mL	5.4146 mL	6.7683 mL
50 mM	0.0541 mL	0.2707 mL	0.5415 mL	1.0829 mL	1.3537 mL
100 mM	0.0271 mL	0.1354 mL	0.2707 mL	0.5415 mL	0.6768 mL