黑芥子苷

Sinigrin

	产品编号	CFN90453
	CAS编号	3952-98-5
	分子式 = 分子量	C₁₀H₁₆KNO₉S₂ = 397.5
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The seeds of Lepidium apetalum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
黑芥子苷	CFN90453	3952-98-5	10mg	QQ客服：215959384
黑芥子苷	CFN90453	3952-98-5	20mg	QQ客服：215959384
黑芥子苷	CFN90453	3952-98-5	50mg	QQ客服：215959384
黑芥子苷	CFN90453	3952-98-5	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Sinigrin has antimicrobial activity. Sinigrin also exerts important anti-proliferative activities in carcinogen-induced hepatocarcinogenesis in rats.

Targets:

p53 | Bcl-2/Bax | Caspase | Antifection

In vitro:

Lett Appl Microbiol. 2015 May 15.

Use of a nanoparticulate carboxymethyl cellulose film containing sinigrin as an antimicrobial precursor to kill Escherichia coli O157:H7 on fresh beef.[Pubmed: 25976711]

METHODS AND RESULTS:
Nanocomposite carboxymethyl cellulose films containing sinigrin (SNG) were prepared by stirring 2% (w/v) carboxymethyl cellulose (CMC) and 2% (w/v) glycerol (as a plasticizer) in distilled water with or without SNG (an antimicrobial precursor) as a 99% pure reagent (pSNG) or as a crude extract (cSNG). These films plus normal CMC film with or without SNG were tested on Escherichia coli O157:H7- inoculated beef for antimicrobial activity. Beef pieces measuring 6 × 5 × 2 cm(3) (L × W × H) were dipped in an E. coli O157:H7 broth suspension containing >8 log10 CFU ml(-1) and were drained for 3 min over a sterile cloth. They were wrapped in CMC or NCMC films, placed in a high oxygen barrier film (Deli *1), vacuum-packaged and stored at 8°C for 5, 8, 12 and 18 days.
CONCLUSIONS:
The CMC and NCMC films without SNG were not antimicrobial against E. coli O157:H7; however, NCMC and CMC films with SNG were highly antimicrobial. After 5 days at 8°C, E. coli O157:H7 was reduced more than 4 log10 by the NCMC•pSNG film and this reduction remained almost the same until 18 days at 8°C when E. coli O157:H7 was reduced >5 log10 CFU g(-1) meat.

In vivo:

PLoS One. 2014 Oct 20;9(10):e110145.

Anti-proliferative activities of sinigrin on carcinogen-induced hepatotoxicity in rats.[Pubmed: 25329483]

Liver cancer is one of the leading causes of cancer death worldwide. A very high incidence of new liver cancer cases is diagnosed every year, and metastasis has been found to correlate to poor prognoses in humans. Better treatments for liver cancer are thus clearly needed. Sinigrin is one of the major ingredients present in Brassica nigra, which has been used in combination with other herbs for treatment of various diseases.
METHODS AND RESULTS:
The anti-proliferative activities of sinigrin were studied in a model of carcinogen-induced hepatotoxicity in rats. Rats were orally administered with sinigrin on a daily basis for three months before sacrifice. Sinigrin was found to significantly inhibit the proliferation of liver tumor cells; the number of surface tumors in the rat liver was dramatically reduced. Sinigrin induced apoptosis of liver cancer cells through up-regulation of p53 and down-regulation of Bcl-2 family members and caspases. Our findings indicated that the liver functions were gradually restored after treatment with sinigrin and that the agent did not cause liver toxicity. Cell cycle analysis indicated that sinigrin caused cell cycle arrest in G0/G1 phase.
CONCLUSIONS:
The results suggest that sinigrin exerts important anti-proliferative activities in carcinogen-induced hepatocarcinogenesis in rats, and highlight the potential of sinigrin as an anti-cancer agent for liver cancer.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
3-甲基亚硫酰丙基硫苷; Glucoiberin	CFN00486	15592-34-4	C₁₁H₂₀KNO₁₀S₃ = 461.6	5mg	QQ客服：215959384
桂竹香苷; Glucocheirolin	CFN00487	15592-36-6	C₁₁H₂₀KNO₁₁S₃ = 477.6	5mg	QQ客服：215959384
硫代葡萄糖苷; Glucoerucin	CFN00488	15592-37-7	C₁₂H₂₂KNO₉S₃ = 459.6	5mg	QQ客服：2159513211
4-甲硫基-3-丁烯基硫代葡萄糖苷; Glucoraphasatin	CFN00482	28463-23-2	C₁₂H₂₀KNO₉S₃ = 457.6	5mg	QQ客服：3257982914
萝卜甙钾盐; Glucoraphenin	CFN00481	108844-81-1	C₁₂H₂₀KNO₁₀S₃ = 473.6	5mg	QQ客服：215959384
萝卜硫苷; Glucoraphanin	CFN93151	21414-41-5	C₁₂H₂₃NO₁₀S₃ = 437.5	5mg	QQ客服：1457312923
5-甲硫戊基硫苷; Glucoberteroin	CFN00495	245550-65-6	C₁₃H₂₄KNO₉S₃ = 473.6	5mg	QQ客服：3257982914
葡萄糖庭荠素; Glucoalyssin	CFN00499	499-37-6	C₁₃H₂₄KNO₁₀S₃ = 489.6	5mg	QQ客服：215959384
Glucohesperin; Glucohesperin	CFN00480	33049-17-1	C₁₄H₂₆KNO₁₀S₃ = 503.7	5mg	QQ客服：2056216494
Glucohirsutin; Glucohirsutin	CFN00498	21973-60-4	C₁₆H₃₀KNO₁₀S₃ = 531.7	5mg	QQ客服：2159513211

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.5157 mL	12.5786 mL	25.1572 mL	50.3145 mL	62.8931 mL
5 mM	0.5031 mL	2.5157 mL	5.0314 mL	10.0629 mL	12.5786 mL
10 mM	0.2516 mL	1.2579 mL	2.5157 mL	5.0314 mL	6.2893 mL
50 mM	0.0503 mL	0.2516 mL	0.5031 mL	1.0063 mL	1.2579 mL
100 mM	0.0252 mL	0.1258 mL	0.2516 mL	0.5031 mL	0.6289 mL

黑芥子苷

Sinigrin

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