水飞蓟宁
Silydianin
|
|
产品编号 |
CFN90242 |
| CAS编号 |
29782-68-1 |
| 分子式 = 分子量 |
C25H22O10 = 482.44 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Flavonoids |
| 植物来源 |
The herbs of Silybum marianum (L.) Gaertn. |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 水飞蓟宁 |
CFN90242 |
29782-68-1 |
10mg |
QQ客服：3257982914 |
| 水飞蓟宁 |
CFN90242 |
29782-68-1 |
20mg |
QQ客服：3257982914 |
| 水飞蓟宁 |
CFN90242 |
29782-68-1 |
50mg |
QQ客服：3257982914 |
| 水飞蓟宁 |
CFN90242 |
29782-68-1 |
100mg |
QQ客服：3257982914 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
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Korea Food Research Institute(KFRI) (Korea)
Leibniz Institute of Plant Biochemistry (Germany)
Instituto Politécnico de Bragan?a (Portugal)
Centralised Purchases Unit (CPU), B.I.T.S (India)
Sri Ramachandra University (India)
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Deutsches Krebsforschungszentrum (Germany)
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Monash University (Australia)
Tohoku University (Japan)
S.N.D.T. Women's University (India)
Universitas islam negeri Jakarta (Indonesia)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Silydianin, an active constituent of Silybium marianum, has inhibitory effect on on the in vitro production and release of oxidative products. Silydianin has possible antiinflammatory activity, which regulates caspase-3 activation, affects cell membranes and acts as a free radical scavenger. |
| Targets: |
Caspase |
| In vitro: |
| Phytother Res. 2006 Feb;20(2):115-9. | | An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species.[Pubmed: 16444663] | The inhibitory effect of silydianin, an active constituent of Silybium marianum, on the in vitro production and release of oxidative products has been examined. Polymorphonuclear neutrophils (PMNs) play a primary role in the initiation and propagation of inflammatory responses. Their apoptosis is a major mechanism associated with the resolution of inflammatory reactions. Neutrophils were assessed for caspase-3 activity, the rst step in the execution phase of apoptosis.
METHODS AND RESULTS:
When cells were cultured with 100 microM silydianin for 24 h, caspase-3 was activated. Induction of apoptosis by silydianin was accompanied by a decrease in luminol-enhanced chemiluminescence as well as superoxide radical (O2*-) release in freshly isolated cells and lipid peroxidation in mouse spleen microsomes. No significant effect of silydianin on PMN hydrogen peroxide production evaluated by a flow cytometric dichlorofluorescin oxidation assay was found.
CONCLUSIONS:
Such results indicate a possible antiinflammatory activity for silydianin, which regulates caspase-3 activation, affects cell membranes and acts as a free radical scavenger. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.0728 mL |
10.364 mL |
20.728 mL |
41.4559 mL |
51.8199 mL |
| 5 mM |
0.4146 mL |
2.0728 mL |
4.1456 mL |
8.2912 mL |
10.364 mL |
| 10 mM |
0.2073 mL |
1.0364 mL |
2.0728 mL |
4.1456 mL |
5.182 mL |
| 50 mM |
0.0415 mL |
0.2073 mL |
0.4146 mL |
0.8291 mL |
1.0364 mL |
| 100 mM |
0.0207 mL |
0.1036 mL |
0.2073 mL |
0.4146 mL |
0.5182 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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