| Description: |
Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects being stronger than that of a representative control, oleanolic acid. Serratenediol can promote the proliferation rate,alkaline phosphate(ALP) activity and some osteogenic gene expression of osteoblasts. Serratenediol also has significant and dose-dependent growth inhibitory effects on HL-60 cells via regulating the ratio of Bax/Bcl-xL.
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| Targets: |
Caspase | PARP | Bcl-xL | Bcl‑2/Bax |
| In vitro: |
| Journal of South-Central University for Nationalities (Natural Science Edition), 2012, 31(3):33-7. | | Effects of Serratenediol on the Osteogenic Activity of Cultured Osteoblasts in vitro.[Reference: WebLink] |
METHODS AND RESULTS:
To study the effect of Serratenediol(an extract from Lycopodium obscurum L.) on the osteogenic activity of cultured osteoblasts,MTT assay、 alkaline phosphate(ALP) assay kit and real-time PCR were used to determine the proliferation rate,ALP activity and osteogenic genes(c-jun、c-fos、Osterix、ALP、Col-Ⅰ、OC) expression of osteoblasts.The results elucidated that treatment of Serratenediol for 3 days could promote the proliferation rate,the expression of c-jun and c-fos genes and first inhibit then enhance Osterix gene of osteoblasts.
CONCLUSIONS:
Serratencdiol treatment for 9 days could enhance the expression of ALP and Col-Ⅰ genes.There was no obvious effect of Serratenediol on the expression of OC.So Serratenediol could promote the proliferation rate,ALP activity and some osteogenic gene expression of osteoblasts.It is one of the effective component from Lycopodium obscurum L.for bone healing. |
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| In vivo: |
| Cancer Lett. 2003 Jul 10;196(2):121-6. | | Cancer chemopreventive activity of serratane-type triterpenoids on two-stage mouse skin carcinogenesis.[Pubmed: 12860269] |
METHODS AND RESULTS:
Eleven serratane-type triterpenoids isolated from the stem bark of Picea jezoensis (Sieb. et Zucc.) Carr. var. jezoensis (Pinaceae) and the stem bark of Picea jezoensis (Sieb. et Zucc.) Carr. var. hondoensis (Mayer) Rehder (Pinaceae) and three synthetic analogs were studied for their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). 21-EpiSerratenediol, Serratenediol, diepiSerratenediol, 3 beta-hydroxyserrat-14-en-21-one, 3 alpha-methoxy-21 beta-hydroxyserrat-14-en-16-one, 3 beta-methoxyserrat-14-en-21 beta-yl acetate, 3 alpha-methoxyserrat-14-en-21 beta-yl acetate and 3 beta-methoxyserrat-14-en-21 alpha-yl acetate demonstrated strong inhibitory effects on the EBV-EA activation without showing any cytotoxicity, their effects being stronger than that of a representative control, oleanolic acid. Furthermore, 21-epiSerratenediol exhibited a remarkable inhibitory effect on skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test using 7,12-dimethylbenz[a]anthracene as an initiator and TPA as a promoter.
CONCLUSIONS:
The result of the present investigation indicated that 21-epiSerratenediol might be valuable as a potent cancer chemopreventive agent. |
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