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  • 王不留行环肽A

    Segetalin A

    王不留行环肽A
    产品编号 CFN93198
    CAS编号 161875-97-4
    分子式 = 分子量 C31H43N7O6 = 609.72
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Vaccaria segetalis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    王不留行环肽A CFN93198 161875-97-4 1mg QQ客服:3257982914
    王不留行环肽A CFN93198 161875-97-4 5mg QQ客服:3257982914
    王不留行环肽A CFN93198 161875-97-4 10mg QQ客服:3257982914
    王不留行环肽A CFN93198 161875-97-4 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Donald Danforth Plant Science Center (USA)
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  • Worcester Polytechnic Institute (USA)
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  • Universidad Miguel Hernández (Spain)
  • Sapienza University of Rome (Italy)
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  • University of Madras (India)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Cell Mol Med.2018, 22(9):4236-4242
  • Nutrients.2019, 11(11):E2694
  • QASCF2022, 14(4).
  • Oxid Med Cell Longev2019, 9056845:13
  • Food and Agriculture Org. Of the UN2019, 151-160
  • Int J Mol Sci.2023, 24(20):15320.
  • Phytother Res.2022, 35844057.
  • Phytother Res.2018, 32(5):923-932
  • Biochem Biophys Res Commun.2020, 530(1):4-9.
  • Int J Mol Sci.2022, 23(21):13406.
  • Plants (Basel).2023, 12(1):163.
  • Sci Rep. 2024, 14(1):70.
  • J Nat Med.2020, 74(1):65-75
  • Acta Physiologiae Plantarum2015, 37:1736
  • Appl Microbiol Biotechnol.2018, 102(12):5105-5120
  • Sci Rep.2019, 9:19059
  • Naunyn Schmiedebergs Arch Pharmacol.2024, 03148-x.
  • J Med Food.2022, 25(3):272-280.
  • Antimicrob Agents Chemother.2020, AAC.01921-20.
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • Industrial Crops and Products2018, 353-362
  • Antioxidants (Basel).2021, 10(10):1620.
  • Revista Brasileira de Farmacognosia2021, 31:794-804.
  • ...
  • 生物活性
    Description: Segetalin A has estrogen-like activity.
    Targets: Estrogen receptor | Progestogen receptor
    In vitro:
    Fitoterapia. 2012 Jan;83(1):170-81.
    Antiproliferative activity of Saponaria vaccaria constituents and related compounds.[Pubmed: 22056663 ]

    METHODS AND RESULTS:
    Total methanolic extracts of Saponaria vaccaria seed derived from several varieties, as well as various purified components obtained through successive chromatographic separations of total extracts were evaluated for their growth inhibitory activity in WiDr (colon), MDA-MB-231 (breast), NCI-417 (lung) and PC-3 (prostate) human cancer cells as well as the non-tumorigenic fibroblast BJ (CRL-2522) cell line using MTT colorimetric assay. Purified bisdesmosidic saponins segetoside H and I were further examined using microscopy and apoptosis assays. Bisdesmosidic saponins exhibited dose-dependent growth inhibitory and selective apoptosis-inducing activity. Growth inhibitory effects were particularly strong in a breast (MDA-MB-231) and a prostate (PC-3) cancer cell line. Total extracts exhibited a different preference being most active against a colon cancer cell line (WiDr). In a comparison of varieties, all of the total seed extracts exhibited similar dose-dependent activities, but with some variation in potency. Monodesmosidic saponins vaccarosides A and B, phenolic vaccarin, and cyclopeptide Segetalin A, co-occurring seed substituents, did not exhibit activity. The non-tumorigenic fibroblast cell line BJ (CRL 2522) was growth inhibited but did not undergo apoptosis when treated with bisdesmosidic saponins at low micromolar concentrations.
    CONCLUSIONS:
    Saponin-rich extracts from Kochia scoparia seed and Chenopodium quinoa were also evaluated alongside Saponaria saponins but did not exhibit activity. Closely related Quillaja saponins exhibited activity but were less potent.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6401 mL 8.2005 mL 16.401 mL 32.8019 mL 41.0024 mL
    5 mM 0.328 mL 1.6401 mL 3.2802 mL 6.5604 mL 8.2005 mL
    10 mM 0.164 mL 0.82 mL 1.6401 mL 3.2802 mL 4.1002 mL
    50 mM 0.0328 mL 0.164 mL 0.328 mL 0.656 mL 0.82 mL
    100 mM 0.0164 mL 0.082 mL 0.164 mL 0.328 mL 0.41 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Lethedioside A; Lethedioside A CFN98201 221289-31-2 C29H34O15 = 622.6 5mg QQ客服:215959384
    (Z)-毛叶醇内酯; (Z)-Lachnophyllum lactone CFN97868 81122-95-4 C10H10O2 = 162.2 5mg QQ客服:2159513211
    奎宁; 无水奎宁; 金鸡纳碱; 金鸡纳霜; Quinine CFN90195 130-95-0 C20H24N2O2 = 324.42 20mg QQ客服:2159513211
    3,3'-O-二甲基鞣花酸; 3,8-Di-O-methylellagic acid CFN98217 2239-88-5 C16H10O8 = 330.3 5mg QQ客服:215959384

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