王不留行环肽A

Segetalin A

	产品编号	CFN93198
	CAS编号	161875-97-4
	分子式 = 分子量	C₃₁H₄₃N₇O₆ = 609.72
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The herbs of Vaccaria segetalis
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
王不留行环肽A	CFN93198	161875-97-4	1mg	QQ客服：2056216494
王不留行环肽A	CFN93198	161875-97-4	5mg	QQ客服：2056216494
王不留行环肽A	CFN93198	161875-97-4	10mg	QQ客服：2056216494
王不留行环肽A	CFN93198	161875-97-4	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

S.N.D.T. Women's University (India)

Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)

John Innes Centre (United Kingdom)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

Instituto Politécnico de Bragan?a (Portugal)

University of Eastern Finland (Finland)

Chulalongkorn University (Thailand)

Universidad de Ciencias y Artes de Chiapas (Mexico)

University of the Basque Country (Spain)

Lund University (Sweden)

University of Dicle (Turkey)

Harvard University (USA)

University of Vigo (Spain)

University of Toronto (Canada)

More...

Description:

Segetalin A has estrogen-like activity.

Targets:

Estrogen receptor | Progestogen receptor

In vitro:

Fitoterapia. 2012 Jan;83(1):170-81.

Antiproliferative activity of Saponaria vaccaria constituents and related compounds.[Pubmed: 22056663 ]

METHODS AND RESULTS:
Total methanolic extracts of Saponaria vaccaria seed derived from several varieties, as well as various purified components obtained through successive chromatographic separations of total extracts were evaluated for their growth inhibitory activity in WiDr (colon), MDA-MB-231 (breast), NCI-417 (lung) and PC-3 (prostate) human cancer cells as well as the non-tumorigenic fibroblast BJ (CRL-2522) cell line using MTT colorimetric assay. Purified bisdesmosidic saponins segetoside H and I were further examined using microscopy and apoptosis assays. Bisdesmosidic saponins exhibited dose-dependent growth inhibitory and selective apoptosis-inducing activity. Growth inhibitory effects were particularly strong in a breast (MDA-MB-231) and a prostate (PC-3) cancer cell line. Total extracts exhibited a different preference being most active against a colon cancer cell line (WiDr). In a comparison of varieties, all of the total seed extracts exhibited similar dose-dependent activities, but with some variation in potency. Monodesmosidic saponins vaccarosides A and B, phenolic vaccarin, and cyclopeptide Segetalin A, co-occurring seed substituents, did not exhibit activity. The non-tumorigenic fibroblast cell line BJ (CRL 2522) was growth inhibited but did not undergo apoptosis when treated with bisdesmosidic saponins at low micromolar concentrations.
CONCLUSIONS:
Saponin-rich extracts from Kochia scoparia seed and Chenopodium quinoa were also evaluated alongside Saponaria saponins but did not exhibit activity. Closely related Quillaja saponins exhibited activity but were less potent.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Trigothysoid N; Trigothysoid N	CFN96570	1501943-08-3	C₄₄H₅₈O₁₃ = 794.95	5mg	QQ客服：1413575084
苦参醇K; Kushenol K	CFN92534	101236-49-1	C₂₆H₃₂O₈ = 472.5	5mg	QQ客服：2159513211
氧化槐定碱; Oxysophoridine	CFN90290	54809-74-4	C₁₅H₂₄N₂O₂ = 264.36	5mg	QQ客服：2159513211
3-Eudesmene-1beta,11-diol; 3-Eudesmene-1beta,11-diol	CFN96794	658062-22-7	C₁₅H₂₆O₂ = 238.37	5mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6401 mL	8.2005 mL	16.401 mL	32.8019 mL	41.0024 mL
5 mM	0.328 mL	1.6401 mL	3.2802 mL	6.5604 mL	8.2005 mL
10 mM	0.164 mL	0.82 mL	1.6401 mL	3.2802 mL	4.1002 mL
50 mM	0.0328 mL	0.164 mL	0.328 mL	0.656 mL	0.82 mL
100 mM	0.0164 mL	0.082 mL	0.164 mL	0.328 mL	0.41 mL