柴胡皂苷元 D

Saikogenin D

	产品编号	CFN93246
	CAS编号	5573-16-0
	分子式 = 分子量	C₃₀H₄₈O₄ = 472.71
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The roots of Bupleurum chinense
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
柴胡皂苷元 D	CFN93246	5573-16-0	1mg	QQ客服：2159513211
柴胡皂苷元 D	CFN93246	5573-16-0	5mg	QQ客服：2159513211
柴胡皂苷元 D	CFN93246	5573-16-0	10mg	QQ客服：2159513211
柴胡皂苷元 D	CFN93246	5573-16-0	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation of [Ca2+]i that is attributed to Ca2+ release from intracellular stores. Saikogenin D has immunomodulatory effect, it can attenuate IL-6 production in LPS-stimulated alveolar macrophages of B6 more than in that of BALB.

Targets:

PGE | Calcium Channel | IL Receptor

In vitro:

Planta Medica, 2003, 69(8):765.

Dual effect of saikogenin D: in vitro inhibition of prostaglandin E2 production and elevation of intracellular free Ca2+ concentration in C6 rat glioma cells.[Pubmed: 14531029]

To clarify the pharmacological profile of Saikogenin D, we examined the effect of Saikogenin D on prostaglandin E2 (PGE2) production and intracellular free Ca2+ concentration ([Ca2+]i) in C6 rat glioma cells.
METHODS AND RESULTS:
Saikogenin D (1-20 microM) inhibited PGE2 production induced by the Ca2+ ionophore A23187 in a concentration-dependent manner with the IC50 of about 3 microM. Saikogenin D did not affect the conversion of arachidonic acid into PGE2 in microsomal preparations. On the other hand, Saikogenin D elevated [Ca2+]i in a concentration-dependent manner (10-100 microM) with the EC50 value of about 35 microM in the presence or absence of extracellular Ca2+.
CONCLUSIONS:
These results suggest that Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation of [Ca2+]i that is attributed to Ca2+ release from intracellular stores.

In vivo:

International Immunopharmacology, 2002, 2(2–3):357-366.

The herbal medicine Shosaiko-to exerts different modulating effects on lung local immune responses among mouse strains[Pubmed: 11811938]

Shosaiko-to (SST), a Chinese/Japanese traditional herbal medicine, has recently been demonstrated to increase lung interleukin-6 (IL-6) levels and to ameliorate pulmonary disorders in BALB/c mice (BALB).
METHODS AND RESULTS:
In the present study, we examined the effects of SST on lung cytokine levels and lipopolysaccharide (LPS)-induced lung injury in C57BL/6 mice (B6), which are known to show different immune responses from BALB due to the difference in genetic backgrounds. In B6, in contrast with BALB, SST decreased lung IL-6 levels and exacerbated LPS-induced lung injury. Investigation of the active components of SST suggested that multiple ingredients were supposed to be responsible for IL-6-attenuating activity in vivo. Further, we examined the effect of metabolites of major ingredients of SST on IL-6 production from lung immune cells in vitro. Saikogenin D and oroxylin A attenuated IL-6 production in LPS-stimulated alveolar macrophages of B6 more than in that of BALB. Liquiritigenin, which was previously reported to enhance IL-6 production in anti-CD3 monoclonal antibody-stimulated lung mononuclear cells of BALB, showed no effect on that of B6.
CONCLUSIONS:
These findings suggest that SST may have different, possibly even opposite, effects on lung immunity in hosts with different genetic backgrounds.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1155 mL	10.5773 mL	21.1546 mL	42.3092 mL	52.8865 mL
5 mM	0.4231 mL	2.1155 mL	4.2309 mL	8.4618 mL	10.5773 mL
10 mM	0.2115 mL	1.0577 mL	2.1155 mL	4.2309 mL	5.2887 mL
50 mM	0.0423 mL	0.2115 mL	0.4231 mL	0.8462 mL	1.0577 mL
100 mM	0.0212 mL	0.1058 mL	0.2115 mL	0.4231 mL	0.5289 mL

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
对羟基苯甲酸丁酯; Butyl 4-Hydroxybenzoate	CFN93302	94-26-8	C₁₁H₁₄O₃ = 194.23	5mg	QQ客服：2056216494
盐酸黄柏碱; Phellodendrine chloride	CFN99144	104112-82-5	C₂₀H₂₄NO₄.Cl = 377.85	20mg	QQ客服：2159513211
京尼平; Genipin	CFN99142	6902-77-8	C₁₁H₁₄O₅ = 226.23	20mg	QQ客服：2159513211
Isoretronecanol; Isoretronecanol	CFN00281	526-63-6	C₈H₁₅NO = 141.21	5mg	QQ客服：1413575084

柴胡皂苷元 D

Saikogenin D

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