S-烯丙基-L-半胱氨酸

S-Allyl-L-cysteine

	产品编号	CFN70240
	CAS编号	21593-77-1
	分子式 = 分子量	C₆H₁₁NO₂S = 161.2
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	From garlic
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
S-烯丙基-L-半胱氨酸	CFN70240	21593-77-1	10mg	QQ客服：215959384
S-烯丙基-L-半胱氨酸	CFN70240	21593-77-1	20mg	QQ客服：215959384
S-烯丙基-L-半胱氨酸	CFN70240	21593-77-1	50mg	QQ客服：215959384
S-烯丙基-L-半胱氨酸	CFN70240	21593-77-1	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Griffith University (Australia)

National Cancer Center Research Institute (Japan)

University of Toronto (Canada)

Max Rubner-Institut (MRI) (Germany)

Hamdard University (India)

Shanghai Institute of Organic Chemistry (China)

Shanghai University of TCM (China)

Kyoto University (Japan)

University of Brasilia (Brazil)

University of Leipzig (Germany)

Universidad de Antioquia (Colombia)

The Vancouver Prostate Centre (VPC) (Canada)

Medizinische Universit?t Wien (Austria)

University of Canterbury (New Zealand)

More...

Description:

S-Allyl-L-cysteine exerts its neuroprotective effect by scavenging ONOO− and inhibiting the ERK signaling pathway activated during initial hypoxic/ischemic insults. S-Allyl-L-cysteine could protect against the neuronal cell death that is triggered by ER dysfunction in the hippocampus, and that it has no effect on neuronal cell death that is dependent upon the caspase-3 mediated pathway.

Targets:

ERK | Caspase | ROS | NO

In vitro:

Neuroence, 2003, 122(4):885-895.

S-allyl-l-cysteine selectively protects cultured rat hippocampal neurons from amyloid β-protein- and tunicamycin-induced neuronal death.[Reference: WebLink]

S-Allyl-L-cysteine (SAC), one of the organosulfur compounds found in aged garlic extract, has been shown to possess various biological effects including neurotrophic activity. In our previous experiments, we found that SAC could protect against amyloid β-protein (Aβ)- and tunicamycin-induced cell death in differentiated PC12 cells.
METHODS AND RESULTS:
In the study described here, we characterized the neuronal death induced by Aβ, 4-hydroxynonenal (HNE), tunicamycin, and trophic factor deprivation, and investigated whether and how SAC could prevent this in cultured rat hippocampal neurons. Treatment with SAC protected these cells against Aβ- and tunicamycin-induced neuronal death, which is mediated predominantly through caspase-12-dependent pathway in a concentration-dependent manner. In contrast, it afforded no protection against HNE- and trophic factor-deprivation-induced cell death, which has been shown to be mediated by caspase-3-dependent pathway. SAC also attenuated the Aβ-induced increase of intracellular reactive oxygen species in hippocampal neurons. SAC had no effect on Aβ-induced cell death in cultured cerebellar granule neurons, which was prevented by a caspase-3 inhibitor.
CONCLUSIONS:
These results suggest that SAC could protect against the neuronal cell death that is triggered by ER dysfunction in the hippocampus, and that it has no effect on neuronal cell death that is dependent upon the caspase-3 mediated pathway.

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.2035 mL	31.0174 mL	62.0347 mL	124.0695 mL	155.0868 mL
5 mM	1.2407 mL	6.2035 mL	12.4069 mL	24.8139 mL	31.0174 mL
10 mM	0.6203 mL	3.1017 mL	6.2035 mL	12.4069 mL	15.5087 mL
50 mM	0.1241 mL	0.6203 mL	1.2407 mL	2.4814 mL	3.1017 mL
100 mM	0.062 mL	0.3102 mL	0.6203 mL	1.2407 mL	1.5509 mL