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  • 草质素苷

    Rhodionin

    草质素苷
    产品编号 CFN99758
    CAS编号 85571-15-9
    分子式 = 分子量 C21H20O11 = 448.38
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Rhodiola rosea
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    草质素苷 CFN99758 85571-15-9 1mg QQ客服:1413575084
    草质素苷 CFN99758 85571-15-9 5mg QQ客服:1413575084
    草质素苷 CFN99758 85571-15-9 10mg QQ客服:1413575084
    草质素苷 CFN99758 85571-15-9 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Regional Crop Research Institute (Korea)
  • Helmholtz Zentrum München (Germany)
  • Universiti Malaysia Pahang (Malaysia)
  • Calcutta University (India)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Colorado State University (USA)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • St. Jude Children Research Hospital (USA)
  • Universit?t Basel (Switzerland)
  • Kitasato University (Japan)
  • Mahatma Gandhi University (India)
  • Medizinische Universit?t Wien (Austria)
  • Florida A&M University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Chem Biol Interact.2019, 298:1-7
  • Acta Edulis Fungi2020, 27(02):63-76.
  • Molecules 2022, 27(3),1047.
  • Analytical sci. & Tech2016, 186-193
  • Int Immunopharmacol.2023, 123:110572.
  • LWT2020, 110397
  • Phytother Res.2022, 35844057.
  • Int J Mol Sci.2015, 16(1):1232-51
  • Pharmaceutical Chemistry Journal2019, 52(12):986-991
  • Chemistry of Plant Raw Materials2022, 20220210569.
  • Biomed Pharmacother.2019, 111:262-269
  • J Pharm Biomed Anal.2017, 140:274-280
  • Journal of Molecular Liquids2022, 364:120062.
  • Front Endocrinol (Lausanne).2020, 11:568436.
  • Tumour Biol.2015, 36(9):7027-34
  • Chinese Journal of Hospital Pharmacy2020, 40(7)
  • Korean j.of Pharm.2017, 70-76
  • Foods.2022, 11(12):1708.
  • Process Biochemistry2019, 87:213-220
  • Heliyon.2023, 9(12):e22932.
  • Plant Direct.2021, 5(4):e00318.
  • University of Guelph2021, 12.
  • Sci Rep.2021, 11(1):14180.
  • ...
  • 生物活性
    Description: Rhodionin and rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administered drugs; they can significantly suppress the elevation of the postprandial blood triglyceride level, suggests that they may be to the treatment of lifestyle-related diseases such as hyperlipidemia and exogeneous obesity and to health foods. Rhodionin has antioxidant activity, it exhibits potent 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging activities, with IC50 values of 19.49 ± 0.21 uM.
    Targets: CYP450 2D6
    In vitro:
    Molecules. 2012 Sep 27;17(10):11484-94.
    The antioxidant and anti-inflammatory effects of phenolic compounds isolated from the root of Rhodiola sachalinensis A. BOR.[Pubmed: 23018923]
    Isolation of compounds from the root of Rhodiola sachalinensis (RRS) yielded tyrosol (1), salidroside (2), multiflorin B (3), kaempferol-3,4'-di-O-β-D-glucopyranoside (4), afzelin (5), kaempferol (6), Rhodionin (7), and rhodiosin (8).
    METHODS AND RESULTS:
    Quantification of these compounds was performed by high-performance liquid chromatography (HPLC). To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity.In this study, 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activity and nitrotetrazolium blue chloride (NBT) superoxide scavenging activity were measured to assess the antioxidant activity of the components from RRS. DPPH has the ability to easily accept hydrogen atoms because it contains an unstable element, the hydrazyl nitrogen, therefore, antioxidant activity can be measured because DPPH loses its violet color when it receives hydrogens from antioxidants [18]. Additionally, NBT has the ability to easily receive superoxide because it contains unstable anions. Therefore, antioxidant activity may be measured when NBT loses its yellow color upon reaction with abundant superoxide [19]. Among the compounds from RRS, 7(Rhodionin) and 8 exhibited the most potent DPPH free radical scavenging activities, with IC50 values of 19.49 ± 0.21 and 27.77 ± 0.61 μM, respectively, compared to the positive control, L-ascorbic acid (IC50 = 32.89 ± 0.70 μM). The other compounds did not exhibit activities in this assay up to 100 μM (Table 2).
    In vivo:
    Planta Med. 2008 Nov;74(14):1716-9.
    Constituents of Rhodiola rosea showing inhibitory effect on lipase activity in mouse plasma and alimentary canal.[Pubmed: 18982538 ]
    As a methanol extract of the rhizome of Rhodiola rosea inhibits the activity of lipase in isolated mouse plasma in vitro and in the mouse gastrointestinal tube in vivo, the active components in this plant were investigated.
    METHODS AND RESULTS:
    After fractionation and separation processes, rhodionin and rhodiosin were isolated as active ingredients. Their IC50 values were 0.093 mM and 0.133 mM in vitro, respectively. Both compounds significantly suppressed the elevation of the postprandial blood triglyceride level, e.g., by 45.6 % (150 mg/kg, 60 min after oral administration) and 57.6 % (200 mg/kg, 180 min after oral administration), respectively.
    CONCLUSIONS:
    Consequently, we anticipate the application of this plant and its constituents to the treatment of lifestyle-related diseases such as hyperlipidemia and exogeneous obesity and to health foods.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2303 mL 11.1513 mL 22.3025 mL 44.605 mL 55.7563 mL
    5 mM 0.4461 mL 2.2303 mL 4.4605 mL 8.921 mL 11.1513 mL
    10 mM 0.223 mL 1.1151 mL 2.2303 mL 4.4605 mL 5.5756 mL
    50 mM 0.0446 mL 0.223 mL 0.4461 mL 0.8921 mL 1.1151 mL
    100 mM 0.0223 mL 0.1115 mL 0.223 mL 0.4461 mL 0.5576 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6-羟基山柰酚-3-O-芸香糖苷; 6-Hydroxykaempferol 3-beta-rutinoside CFN91147 205527-00-0 C27H30O16 = 610.5 5mg QQ客服:3257982914
    6-羟基山奈酚 3-芸香糖-6-葡萄糖苷; 6-Hydroxykaempferol 3-Rutinoside -6-glucoside CFN92575 145134-63-0 C33H40O21 = 772.7 5mg QQ客服:3257982914
    山奈酚-4'-O-β-D-葡萄糖苷; Kaempferol-4'-O-beta-D-glucopyranoside CFN80457 52222-74-9 C21H20O11 = 448.38 5mg QQ客服:3257982914
    鼠李柠檬素-3-O-β-D-呋喃芹菜糖-( 1->2) -β-D-葡糖糖苷; Rhamnocitrin 3-apiosyl-(1->2)-glucoside CFN95145 148031-68-9 C27H30O15 = 594.5 10mg QQ客服:2056216494
    鼠李柠檬素-3-O-[5'''-O-阿魏酰-β-D-呋喃芹菜糖-(1'''→2''')]-β-D-吡喃葡萄糖苷; 3-O-[5'''-O-feruloyl-beta-D-apiofuranosyl(1'''->2'')-beta-D-glucopyranosyl] rhamnocitrin CFN95154 148210-00-8 C37H38O18 = 770.7 5mg QQ客服:1457312923
    氧氟草苷A; Oxytroflavoside A CFN95463 1391144-80-1 C34H40O19 = 752.7 5mg QQ客服:3257982914
    氧氟草苷B; Oxytroflavoside B CFN95490 1391144-81-2 C34H40O19 = 752.7 10mg QQ客服:2159513211
    沙苑子苷; Complanatoside CFN91011 116183-66-5 C28H32O16 = 624.6 20mg QQ客服:1457312923
    氧氟草苷E; Oxytroflavoside E CFN95464 1391144-84-5 C34H40O20 = 768.7 5mg QQ客服:2056216494
    沙苑子苷B; Complanatoside B CFN80156 142473-99-2 C33H40O20 = 756.66 10mg QQ客服:1457312923

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