勒胖停；土大黄苷

Rhaponiticin

	产品编号	CFN98569
	CAS编号	155-58-8
	分子式 = 分子量	C₂₁H₂₄O₉ = 420.39
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The roots of Rumex obtusifolius L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
勒胖停；土大黄苷	CFN98569	155-58-8	10mg	QQ客服：2056216494
勒胖停；土大黄苷	CFN98569	155-58-8	20mg	QQ客服：2056216494
勒胖停；土大黄苷	CFN98569	155-58-8	50mg	QQ客服：2056216494
勒胖停；土大黄苷	CFN98569	155-58-8	100mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Nicolaus Copernicus Uniwersity (Poland)

Chulalongkorn University (Thailand)

The Institute of Cancer Research (United Kingdom)

Kyung Hee University (Korea)

Instituto Politécnico de Bragan?a (Portugal)

Anna University (India)

University of Minnesota (USA)

University of Zurich (Switzerland)

Medical University of South Carolina (USA)

University of Wuerzburg (Germany)

Semmelweis Unicersity (Hungary)

University of Wollongong (Australia)

Washington State University (USA)

Texas A&M University (USA)

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Description:

Rhaponticin(Rhaponiticin) has a noticeable antidiabetic effect and could be potentially used as a new agent to treat type 2 diabetes mellitus and its complications, it can alleviate liver steatosis and improve blood glucose and lipid profiles in KK/Ay diabetic mice.

Targets:

LDL

In vivo:

Planta Med. 2009 Apr;75(5):472-7.

Rhaponticin from rhubarb rhizomes alleviates liver steatosis and improves blood glucose and lipid profiles in KK/Ay diabetic mice.[Pubmed: 19235684]

We isolated several stilbene compounds including rhaponticin (Rhaponiticin,3',5-dihydroxy-4'-methoxystilbene 3- O-beta- D-glucopyranoside) from extracts of rhubarb rhizomes. These compounds showed significant hypoglycemic effects in streptozotocin (STZ)-induced type 1 diabetic rats and mice.
METHODS AND RESULTS:
In this study, we investigated the effect of rhaponticin on glucose utilization, lipid metabolism, and liver and heart function in a KK/Ay type 2 diabetic mouse model. The results showed that oral administration of rhaponticin (125 mg/kg) significantly reduced blood glucose levels and improved oral glucose tolerance of KK/Ay diabetic mice. Elevated plasma triglyceride (TG), low density lipoprotein (LDL), cholesterol (CHO), non-esterified free fatty acids (NEFA), and insulin levels were also markedly attenuated. Serum enzymatic activities of lactate dehydrogenase (LDH), creatine kinase (CK), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the rhaponticin-treated group significantly decreased in comparison to the untreated model group. Livers of rhaponticin-treated mice had relatively normal cellular size and decreased fibrosis and steatosis. In addition, rhaponticin administration caused a remarkable increase in the hepatic glycogen content and a significant reduction in the hepatic triglyceride content.
CONCLUSIONS:
These results indicate that rhaponticin has a noticeable antidiabetic effect and could be potentially used as a new agent to treat type 2 diabetes mellitus and its complications.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
桑皮苷A; Mulberroside A	CFN99586	102841-42-9	C₂₆H₃₂O₁₄ = 568.52	20mg	QQ客服：2056216494
cis-桑皮苷A; cis-Mulberroside A	CFN95006	166734-06-1	C₂₆H₃₂O₁₄ = 568.52	10mg	QQ客服：1457312923
Gnetucleistol D; Gnetucleistol D	CFN92443	629643-26-1	C₁₅H₁₄O₄ = 258.3	5mg	QQ客服：3257982914
买麻藤醇; Gnetol	CFN92425	86361-55-9	C₁₄H₁₂O₄ = 244.2	20mg	QQ客服：215959384
Gnetucleistol B; Gnetucleistol B	CFN92678	864763-60-0	C₁₅H₁₄O₅ = 274.3	5mg	QQ客服：2056216494
丹酚酸F; Salvianolic acid F	CFN90811	158732-59-3	C₁₇H₁₄O₆ = 314.3	5mg	QQ客服：2159513211
异丹叶大黄素; Isorhapotogenin	CFN92426	32507-66-7	C₁₅H₁₄O₄ = 258.3	20mg	QQ客服：215959384
5-[2-(4-羟基-3-甲氧基苯基)乙基]-1,3-苯二酚; Tristin	CFN97824	139101-67-0	C₁₅H₁₆O₄ = 260.29	5mg	QQ客服：1457312923
丹叶大黄素; Rhapontigenin	CFN92607	500-65-2	C₁₅H₁₄O₄ = 258.3	20mg	QQ客服：2056216494
勒胖停；土大黄苷; Rhaponiticin	CFN98569	155-58-8	C₂₁H₂₄O₉ = 420.39	20mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3787 mL	11.8937 mL	23.7874 mL	47.5749 mL	59.4686 mL
5 mM	0.4757 mL	2.3787 mL	4.7575 mL	9.515 mL	11.8937 mL
10 mM	0.2379 mL	1.1894 mL	2.3787 mL	4.7575 mL	5.9469 mL
50 mM	0.0476 mL	0.2379 mL	0.4757 mL	0.9515 mL	1.1894 mL
100 mM	0.0238 mL	0.1189 mL	0.2379 mL	0.4757 mL	0.5947 mL

勒胖停； 土大黄苷

Rhaponiticin

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勒胖停；土大黄苷