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  • 勒胖停; 土大黄苷

    Rhaponiticin

    勒胖停; 土大黄苷
    产品编号 CFN98569
    CAS编号 155-58-8
    分子式 = 分子量 C21H24O9 = 420.39
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The roots of Rumex obtusifolius L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    勒胖停; 土大黄苷 CFN98569 155-58-8 10mg QQ客服:215959384
    勒胖停; 土大黄苷 CFN98569 155-58-8 20mg QQ客服:215959384
    勒胖停; 土大黄苷 CFN98569 155-58-8 50mg QQ客服:215959384
    勒胖停; 土大黄苷 CFN98569 155-58-8 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Appl. Sci.2023, 13(17), 9653.
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  • Heliyon.2022, 8(12):e12031.
  • Molecules.2021, 26(18):5665.
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  • Plant Physiol Biochem.2019, 144:355-364
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  • Korean Herb. Med. Inf.2020, 8(2):233-242.
  • J Korean Soc Food Sci Nutr2020, doi: 10.3746.
  • Univerzita Karlova2021, 20.500.11956.
  • Antioxidants (Basel).2021, 10(10):1638.
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  • ...
  • 生物活性
    Description: Rhaponticin(Rhaponiticin) has a noticeable antidiabetic effect and could be potentially used as a new agent to treat type 2 diabetes mellitus and its complications, it can alleviate liver steatosis and improve blood glucose and lipid profiles in KK/Ay diabetic mice.
    Targets: LDL
    In vivo:
    Planta Med. 2009 Apr;75(5):472-7.
    Rhaponticin from rhubarb rhizomes alleviates liver steatosis and improves blood glucose and lipid profiles in KK/Ay diabetic mice.[Pubmed: 19235684]
    We isolated several stilbene compounds including rhaponticin (Rhaponiticin,3',5-dihydroxy-4'-methoxystilbene 3- O-beta- D-glucopyranoside) from extracts of rhubarb rhizomes. These compounds showed significant hypoglycemic effects in streptozotocin (STZ)-induced type 1 diabetic rats and mice.
    METHODS AND RESULTS:
    In this study, we investigated the effect of rhaponticin on glucose utilization, lipid metabolism, and liver and heart function in a KK/Ay type 2 diabetic mouse model. The results showed that oral administration of rhaponticin (125 mg/kg) significantly reduced blood glucose levels and improved oral glucose tolerance of KK/Ay diabetic mice. Elevated plasma triglyceride (TG), low density lipoprotein (LDL), cholesterol (CHO), non-esterified free fatty acids (NEFA), and insulin levels were also markedly attenuated. Serum enzymatic activities of lactate dehydrogenase (LDH), creatine kinase (CK), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the rhaponticin-treated group significantly decreased in comparison to the untreated model group. Livers of rhaponticin-treated mice had relatively normal cellular size and decreased fibrosis and steatosis. In addition, rhaponticin administration caused a remarkable increase in the hepatic glycogen content and a significant reduction in the hepatic triglyceride content.
    CONCLUSIONS:
    These results indicate that rhaponticin has a noticeable antidiabetic effect and could be potentially used as a new agent to treat type 2 diabetes mellitus and its complications.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3787 mL 11.8937 mL 23.7874 mL 47.5749 mL 59.4686 mL
    5 mM 0.4757 mL 2.3787 mL 4.7575 mL 9.515 mL 11.8937 mL
    10 mM 0.2379 mL 1.1894 mL 2.3787 mL 4.7575 mL 5.9469 mL
    50 mM 0.0476 mL 0.2379 mL 0.4757 mL 0.9515 mL 1.1894 mL
    100 mM 0.0238 mL 0.1189 mL 0.2379 mL 0.4757 mL 0.5947 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    勒胖停; 土大黄苷; Rhaponiticin CFN98569 155-58-8 C21H24O9 = 420.39 20mg QQ客服:2159513211
    异土大黄苷; Isorhapontin CFN91655 32727-29-0 C21H24O9 = 420.4 5mg QQ客服:3257982914
    丹叶大黄素-3'-O-葡萄糖苷; Rhapontigenin 3'-O-glucoside CFN90749 94356-22-6 C21H24O9 = 420.4 10mg QQ客服:3257982914
    曲札茋苷、白皮杉醇-3'-O-葡萄糖苷; Piceatannol 3'-O-glucoside CFN90750 94356-26-0 C20H22O9 = 406.4 20mg QQ客服:1413575084
    白皮杉醇葡萄糖苷; Astringin CFN92486 29884-49-9 C20H22O9 = 406.4 5mg QQ客服:3257982914
    毛兰素; Erianin CFN90204 95041-90-0 C18H22O5 = 318.36 20mg QQ客服:2159513211
    氧化白藜芦醇; Oxyresveratrol CFN98368 29700-22-9 C14H12O4 = 244.2 20mg QQ客服:1457312923
    氧化白藜芦醇-2-O-D-吡喃葡萄糖苷; Oxyresveratrol 2-O-beta-D-glucopyranoside CFN90789 392274-22-5 C20H22O9 = 406.4 5mg QQ客服:215959384
    氧化白藜芦醇-3'-O-β-D-吡喃葡萄糖苷; Oxyresveratrol 3'-O-beta-D-glucopyranoside CFN90793 144525-40-6 C20H22O9 = 406.4 5mg QQ客服:1457312923
    桑皮苷A; Mulberroside A CFN99586 102841-42-9 C26H32O14 = 568.52 20mg QQ客服:215959384

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