茯苓酸B

Poricoic acid B

	产品编号	CFN95050
	CAS编号	137551-39-4
	分子式 = 分子量	C₃₀H₄₄O₅ = 484.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The roots of Wolfiporia cocos (Schw.) Ryv.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
茯苓酸B	CFN95050	137551-39-4	10mg	QQ客服：215959384
茯苓酸B	CFN95050	137551-39-4	20mg	QQ客服：215959384
茯苓酸B	CFN95050	137551-39-4	50mg	QQ客服：215959384
茯苓酸B	CFN95050	137551-39-4	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Wisconsin-Madison (USA)

Universidade Católica Portuguesa (Portugal)

University of Melbourne (Australia)

Deutsches Krebsforschungszentrum (Germany)

Utah State University (USA)

Universidad de Buenos Aires (Argentina)

Instituto de Investigaciones Agropecuarias (Chile)

Indian Institute of Science (India)

Guangzhou Institutes of Biomedicine and Health (China)

VIT University (India)

Aveiro University (Portugal)

University Medical Center Mainz (Germany)

University of Vienna (Austria)

Celltrion Chemical Research Institute (Korea)

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Description:

Poricoic acid B shows inhibitory activity against TPA-induced ear inflammatory oedema, it also shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).

In vitro:

J Nat Prod. 2002 Apr;65(4):462-5.

Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.[Pubmed: 11975480]

The structures of two novel 3,4-seco-lanostane-type triterpenes isolated from the sclerotium of Poria cocos were established to be 16alpha-hydroxy-3,4-seco-lanosta-4(28),8,24-triene-3,21-dioic acid (1; poricoic acid G) and 16alpha-hydroxy-3,4-seco-24-methyllanosta-4(28),8,24(24(1))-triene-3,21-dioic acid (2; poricoic acid H) on the basis of spectroscopic methods.
METHODS AND RESULTS:
These two, and eight other known compounds isolated from the sclerotium, Poricoic acid B (3), poricoic acid A (4), tumulosic acid (5), dehydrotumulosic acid (6), 3-epidehydrotumulosic acid (7), polyporenic acid C (8), 25-hydroxy-3-epidehydrotumulosic acid (9), and dehydroabietic acid methyl ester (10), showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Evaluation of the cytotoxicity of compounds 1 and 4 against human cancer cell lines revealed that 1 was significantly cytotoxic to leukemia HL-60 cells [GI(50) (concentration that yields 50% growth) value 39.3 nM], although it showed only moderate cytotoxicity to the other cells. Compound 4 exhibited moderate cytotoxicity to all of the cancer cell lines tested.

In vivo:

Phytotherapy Research,1996,10(7):581-4.

Inhibitory Effect of Poria cocos on 12-O-Tetradecanoylphorbol-13Acetate‐Induced Ear Oedema and Tumour Promotion in Mouse Skin[Reference: WebLink]

The methanol extract from the sclerotium of Poria cocos was found to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumour promotion in two-stage carcinogenesis in mouse skin.
METHODS AND RESULTS:
From the active fraction of the extract, eight lanostane-type triterpene acids and four 3,4-secolanostane-type triterpene acids were isolated. The isolated compounds showed inhibitory activity against TPA-induced ear inflammatory oedema. The 50% inhibitory dose of pachymic acid, 3-O-acetyl-16α-hydroxytrametenolic acid, dehydropachymic acid, dehydroeburiconic acid, 3β-hydroxylanosta-7,9(11),24-trien-21-oic acid, poricoic acid A and Poricoic acid B for TPA-induced inflammation was 17–44 μg/ear, at a grade corresponding to that of hydrocortisone.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
茯苓酸B; Poricoic acid B	CFN95050	137551-39-4	C₃₀H₄₄O₅ = 484.7	20mg	QQ客服：1457312923
茯苓酸G; Poricoic acid G	CFN95056	415724-84-4	C₃₀H₄₆O₅ = 486.7	5mg	QQ客服：215959384
大戟二烯醇; Euphol	CFN89516	514-47-6	C₃₀H₅₀O = 426.71	10mg	QQ客服：2159513211
大戟醇; Euphorbol	CFN91600	566-14-3	C₃₁H₅₂O = 440.7	5mg	QQ客服：1413575084
羊毛甾醇; Lanosterol	CFN92368	79-63-0	C₃₀H₅₀O = 426.7	20mg	QQ客服：215959384
丁酰鲸鱼醇; Butyrospermol	CFN92376	472-28-6	C₃₀H₅₀O = 426.7	5mg	QQ客服：2056216494
苦楝酮; Kulinone	CFN92977	21688-61-9	C₃₀H₄₈O₂ = 440.70	5mg	QQ客服：3257982914
Aphagranin A ; Aphagranin A	CFN96579	1318173-53-3	C₃₃H₅₄O₆ = 546.79	5mg	QQ客服：2056216494
金钱松呋喃酸; Pseudolarifuroic acid	CFN91924	130825-79-5	C₃₀H₄₂O₄ = 466.65	5mg	QQ客服：2056216494
3-氧代甘遂-7,24-二烯-21-酸; 3-Oxotirucalla-7,24-dien-21-oic acid	CFN97609	82464-35-5	C₃₀H₄₆O₃ = 454.69	5mg	QQ客服：1457312923

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0631 mL	10.3157 mL	20.6313 mL	41.2626 mL	51.5783 mL
5 mM	0.4126 mL	2.0631 mL	4.1263 mL	8.2525 mL	10.3157 mL
10 mM	0.2063 mL	1.0316 mL	2.0631 mL	4.1263 mL	5.1578 mL
50 mM	0.0413 mL	0.2063 mL	0.4126 mL	0.8253 mL	1.0316 mL
100 mM	0.0206 mL	0.1032 mL	0.2063 mL	0.4126 mL	0.5158 mL

茯苓酸B

Poricoic acid B

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