大黄素甲醚-8-O-β-D-葡萄糖苷

Physcion 8-O-beta-D-monoglucoside

	产品编号	CFN80399
	CAS编号	23451-01-6
	分子式 = 分子量	C₂₂H₂₂O₁₀ = 446.4
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Anthraquinones
	植物来源	The roots and rhizomes of Rheum palmatum L
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
大黄素甲醚-8-O-β-D-葡萄糖苷	CFN80399	23451-01-6	1mg	QQ客服：3257982914
大黄素甲醚-8-O-β-D-葡萄糖苷	CFN80399	23451-01-6	5mg	QQ客服：3257982914
大黄素甲醚-8-O-β-D-葡萄糖苷	CFN80399	23451-01-6	10mg	QQ客服：3257982914
大黄素甲醚-8-O-β-D-葡萄糖苷	CFN80399	23451-01-6	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University Medical Center Mainz (Germany)

University of East Anglia (United Kingdom)

Charles Sturt University (Denmark)

University of Leipzig (Germany)

Rio de Janeiro State University (Brazil)

Lund University (Sweden)

Korea Institute of Oriental Medicine (Korea)

Regional Crop Research Institute (Korea)

National Cancer Institute (USA)

Universidade da Beira Interior (Germany)

Georgia Institute of Technology (USA)

Technical University of Denmark (Denmark)

Worcester Polytechnic Institute (USA)

Universiti Sains Malaysia (Malaysia)

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Description:

Physcion 8-O-beta-D-monoglucoside has anti-inflammatory activity, it can inhibit TNF-α-induced cytotoxicity and apoptosis in L929 cells via TNF-R1.

Targets:

TNF-α

In vitro:

Anal Bioanal Chem. 2016 Jul;408(19):5359-67.

Identification of a ligand for tumor necrosis factor receptor from Chinese herbs by combination of surface plasmon resonance biosensor and UPLC-MS.[Pubmed: 27225174]

Identification of bioactive compounds directly from complex herbal extracts is a key issue in the study of Chinese herbs.
METHODS AND RESULTS:
The present study describes the establishment and application of a sensitive, efficient, and convenient method based on surface plasmon resonance (SPR) biosensors for screening active ingredients targeting tumor necrosis factor receptor type 1 (TNF-R1) from Chinese herbs. Concentration-adjusted herbal extracts were subjected to SPR binding assay, and a remarkable response signal was observed in Rheum officinale extract. Then, the TNF-R1-bound ingredients were recovered, enriched, and analyzed by UPLC-QTOF/MS. As a result, Physcion 8-O-beta-D-monoglucoside (PMG) was identified as a bioactive compound, and the affinity constant of PMG to TNF-R1 was determined by SPR affinity analysis (K D = 376 nM). Pharmacological assays revealed that PMG inhibited TNF-α-induced cytotoxicity and apoptosis in L929 cells via TNF-R1. Although PMG was a trace component in the chemical constituents of the R. officinale extract, it had considerable anti-inflammatory activities.
CONCLUSIONS:
It was found for the first time that PMG was a ligand for TNF receptor from herbal medicines. The proposed SPR-based screening method may prove to be an effective solution to analyzing bioactive components of Chinese herbs and other complex drug systems. Graphical abstract Scheme of the method based on SPR biosensor for screening and recovering active ingredients from complex herbal extracts and UPLC-MS for identifying them. Scheme of the method based on SPR biosensor for screening and recovering active ingredients from complex herbal extracts and UPLC-MS for identifying them.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
芦西定 3-O-葡萄糖苷; Lucidin 3-O-glucoside	CFN91032	22255-29-4	C₂₁H₂₀O₁₀ = 432.38	5mg	QQ客服：2159513211
3-(beta-D-Glucopyranosyloxy)-1,6-dihydroxy-2-methyl-9,10-anthracenedione; 3-(beta-D-Glucopyranosyloxy)-1,6-dihydroxy-2-methyl-9,10-anthracenedione	CFN91796	125906-49-2	C₂₁H₂₀O₁₀ = 432.38	5mg	QQ客服：2056216494
1,3,6-三羟基-2-甲基蒽醌-3-O-新橙皮糖苷; 1,3,6-Trihydroxy-2-methylanthraquinone 3-O-alpha-L-rhamnosyl-(1->2)-beta-D-glucoside	CFN95096	87686-88-2	C₂₇H₃₀O₁₄ = 578.5	10mg	QQ客服：3257982914
檄树素苷; Morindin	CFN70420	60450-21-7	C₂₆H₂₈O₁₄ = 564.5	5mg	QQ客服：2056216494
大黄酸-8-葡萄糖苷钙盐; Rhein-8-glucoside calcium salt	CFN99592	113443-70-2	C₂₁H₁₆O₁₁.Ca = 484.43	5mg	QQ客服：215959384
胭脂红; Carmine	CFN90066	2611-82-7	C₂₀H₁₁N₂O₁₀S₃ = 534.9	20mg	QQ客服：1457312923
芦荟素B; Aloin B	CFN90434	28371-16-6	C₂₁H₂₂O₉ = 418.39	20mg	QQ客服：3257982914
10-羟基芦荟苷B; 10-Hydroxyaloin B	CFN95454	134863-92-6	C₂₁H₂₂O₁₀ = 434.4	5mg	QQ客服：1457312923
Barbaloin-related compound A; Barbaloin-related compound A	CFN95453	473225-21-7	C₄₂H₄₂O₁₈ = 834.8	5mg	QQ客服：2159513211
Barbaloin-related compound B; Barbaloin-related compound B	CFN95455	473225-22-8	C₄₂H₄₂O₁₈ = 834.8	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2401 mL	11.2007 mL	22.4014 mL	44.8029 mL	56.0036 mL
5 mM	0.448 mL	2.2401 mL	4.4803 mL	8.9606 mL	11.2007 mL
10 mM	0.224 mL	1.1201 mL	2.2401 mL	4.4803 mL	5.6004 mL
50 mM	0.0448 mL	0.224 mL	0.448 mL	0.8961 mL	1.1201 mL
100 mM	0.0224 mL	0.112 mL	0.224 mL	0.448 mL	0.56 mL