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  • 大蓟苷


    产品编号 CFN99727
    CAS编号 28978-02-1
    分子式 = 分子量 C29H34O15 = 622.57
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Cirsium japonicum DC.
    产品名称 产品编号 CAS编号 包装 QQ客服
    大蓟苷 CFN99727 28978-02-1 10mg QQ客服:1457312923
    大蓟苷 CFN99727 28978-02-1 20mg QQ客服:1457312923
    大蓟苷 CFN99727 28978-02-1 50mg QQ客服:1457312923
    大蓟苷 CFN99727 28978-02-1 100mg QQ客服:1457312923
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
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  • Universidad de Buenos Aires (Argentina)
  • University of Sao Paulo (Brazil)
  • University of Canterbury (New Zealand)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Chiang Mai University (Thailand)
  • Helmholtz Zentrum München (Germany)
  • Michigan State University (USA)
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  • ...
  • 生物活性
    Description: Pectolinarin has antioxidant, antiobesity, analgesic, and hepatoprotective activity, it may inhibit eicosanoid formation in inflammatory lesions.
    Targets: COX | NF-kB | PGE
    In vitro:
    Food Sci. Biotech., 2015, 24(6):2235-43.
    Assessment of the pectolinarin content and the radical scavenging-linked antiobesity activity of Cirsium setidens Nakai extracts.[Reference: WebLink]
    Cirsium setidens Nakai contains bioactive compounds that exert biological activities.
    Method validation for analysis of the pectolinarin content in Cirsium setidens extracts (CSE) and radical scavenging-linked antiobesity activities using 3T3-L1 cells and C57BL/6 mice were performed. The pectolinarin content of CSE was 2.81±0.01 mg/g with a high degree of linearity in calibration curves (R 2=0.9999). CSE exhibited free radical-scavenging activities and a reducing power. CSE and pectolinarin inhibited lipid accumulation during adipogenesis of 3T3-L1 cells via down-regulation of adipogenic transcription factors. CSE supplementation suppressed body weight in C57BL/6 mice fed a high fat diet and reduced plasma total cholesterol, triglyceride, insulin, and glucose levels.
    Pectolinarin-enriched CSE can be considered as a good source of natural antioxidants and antiobesity ingredients.
    J Cell Biochem . 2019 Sep;120(9):15202-15210.
    Pectolinarin inhibits proliferation, induces apoptosis, and suppresses inflammation in rheumatoid arthritis fibroblast-like synoviocytes by inactivating the phosphatidylinositol 3 kinase/protein kinase B pathway[Pubmed: 31020684]
    Abstract Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs), a pathological hallmark of rheumatoid arthritis (RA), exhibit the characteristics of tumor cells. The extracts of Cirsium japonicum var. ussuriense have been shown to possess antitumor and anti-inflammatory activities. Our study aimed to investigate the effects of pectolinarin, a flavonoid compound isolated from C. japonicum var. ussuriense, on RA. Cell viability was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay. Apoptosis was determined by flow cytometry analysis and Western blot analysis of Bax and Bcl-2 levels. Inflammation was assessed by detecting the expressions and secretion of interleukin (IL)-6 and IL-8 using quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. The production of nitric oxide (NO) and prostaglandin E2 (PGE2) was also measured. The effects of pectolinarin on the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt) pathway were examined by Western blot. We found that pectolinarin significantly inhibited cell viability at 24 and 48 hours in a dose-dependently manner in RA-FLSs. Pectolinarin reduced the apoptotic rate, increased Bax level, and decreased Bcl-2 level in RA-FLSs. Pectolinarin inhibited the messenger RNA expression and secretion of IL-6 and IL-8, as well as the production of PGE2 and NO in RA-FLSs. Furthermore, pectolinarin inactivated the phosphatidylinositol 3 kinase/protein kinase B (PI3K/Akt) pathway in RA-FLSs. Activation of the PI3K/Akt pathway by 740Y-P impaired the effects of pectolinarin on cell viability, apoptosis, and inflammation in RA-FLSs. In conclusion, pectolinarin suppressed cell proliferation and inflammatory response and induced apoptosis in RA-FLSs via inactivation of the PI3K/Akt pathway. Keywords: apoptosis; inflammation; pectolinarin; rheumatoid arthritis fibroblast-like synoviocytes; the phosphatidylinositol 3 kinase/protein kinase B pathway.
    In vivo:
    Biol Pharm Bull. 2008 Nov;31(11):2063-7.
    Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum.[Pubmed: 18981574]

    In order to identify the active anti-inflammatory ingredient(s) in Cirsium chanroenicum (Compositae), its methanol extract and several solvent fractions were prepared; the methanol extract and the ethylacetate fraction inhibited cyclooxygenase-2 (COX-2)-mediated prostaglandin E2 (PGE2) and 5-lipoxygenase (5-LOX)-mediated leukotriene (LT) production in lipopolysaccharide-treated RAW 264.7 cells and A23187-treated rat basophilic leukemia (RBL-1) cells, respectively. Further bioactivity-guided fractionation of the ethylacetate fraction using column chromatography led to the isolation of pectolinarigenin (5,7-dihydroxy-4',6-dimethoxyflavone), along with pectolinarin [pectolinarigenin 7-rhamnosyl-(1-->6)-glucoside]. Pectolinarigenin strongly inhibited COX-2-mediated PGE2 and 5-LOX-mediated LT production at >1 microM, indicating that it is a dual inhibitor of COX-2/5-LOX. However, pectolinarigenin did not affect COX-2 expression or nuclear transcription factor (NF-kappaB) activation. In addition, in vivo studies demonstrated that oral administration of these two compounds at 20-100 mg/kg resulted in similar inhibitory activities against several animal models of inflammation/allergy: arachidonic acid-induced mouse ear edema, carrageenan-induced mouse paw edema and passive cutaneous anaphylaxis.
    All of these results suggest that pectolinarigenin and pectolinarin possess anti-inflammatory activity and that they may inhibit eicosanoid formation in inflammatory lesions. These activities certainly contribute to the anti-inflammatory mechanism of C. chanroenicum.
    Planta Med. 1998 Mar;64(2):134-7.
    A comparative study of the analgesic and anti-inflammatory activities of pectolinarin isolated from Cirsium subcoriaceum and linarin isolated from Buddleia cordata.[Pubmed: 9525105]

    The dried aqueous extract of aerial parts of Cirsium subcoriaceum (Asteraceae) and its major flavonoid glycoside, pectolinarin, have been evaluated for analgesic and anti-inflammatory effects in mice and rats, respectively. Both the extract and pectolinarin exerted significant and dose-dependent analgesic and anti-inflammatory activities. Also, the anti-inflammatory activities of an aqueous extract of Buddleia cordata and its principal glycoside linarin were evaluated.
    The results of pharmacological testing proved that linarin is a better anti-inflammatory agent than pectolinarin and indomethacin. On the other hand, pectolinarin exerted a better analgesic effect than linarin.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6062 mL 8.0312 mL 16.0625 mL 32.1249 mL 40.1561 mL
    5 mM 0.3212 mL 1.6062 mL 3.2125 mL 6.425 mL 8.0312 mL
    10 mM 0.1606 mL 0.8031 mL 1.6062 mL 3.2125 mL 4.0156 mL
    50 mM 0.0321 mL 0.1606 mL 0.3212 mL 0.6425 mL 0.8031 mL
    100 mM 0.0161 mL 0.0803 mL 0.1606 mL 0.3212 mL 0.4016 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-甲氧基-4,5-亚甲基二氧基肉桂醛; 3-Methoxy-4,5-methylenedioxycinnamaldehyde CFN97228 74683-19-5 C11H10O4 = 206.2 5mg QQ客服:3257982914
    豯莶苷; Darutoside CFN97004 59219-65-7 C26H44O8 = 484.6 20mg QQ客服:215959384
    6alpha-羟基去氢茯苓酸; 6alpha-Hydroxydehydropachymic acid CFN95412 176390-67-3 C33H50O6 = 542.8 5mg QQ客服:3257982914
    8-羟基松脂醇-4'-O-beta-D-吡喃葡萄糖苷; 8-Hydroxypinoresinol-4'-O-beta-D-glucopyranoside CFN95356 102582-69-4 C26H32O12 = 536.5 5mg QQ客服:1457312923





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