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  • 人参环氧炔醇

    Panaxydol

    人参环氧炔醇
    产品编号 CFN92797
    CAS编号 72800-72-7
    分子式 = 分子量 C17H24O2 = 260.4
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Miscellaneous
    植物来源 The roots of Panax ginseng C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    人参环氧炔醇 CFN92797 72800-72-7 10mg QQ客服:2056216494
    人参环氧炔醇 CFN92797 72800-72-7 20mg QQ客服:2056216494
    人参环氧炔醇 CFN92797 72800-72-7 50mg QQ客服:2056216494
    人参环氧炔醇 CFN92797 72800-72-7 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Instituto Politécnico de Bragan?a (Portugal)
  • Universitas Airlangga (Indonesia)
  • Chungnam National University (Korea)
  • University of Padjajaran (Indonesia)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • University of Hawaii Cancer Center (USA)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Regional Crop Research Institute (Korea)
  • Sant Gadge Baba Amravati University (India)
  • Siksha O Anusandhan University (India)
  • Center for protein Engineering (CIP) (Belgium)
  • Helmholtz Zentrum München (Germany)
  • Kazusa DNA Research Institute (Japan)
  • Monash University Sunway Campus (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Dicle Tip Dergisi2020, 47(2),423-430.
  • Free Radic Biol Med.2016, 97:307-319
  • Phytochem Anal.2013, 24(5):493-503
  • Pharmacol Rep.2017, 69(6):1224-1231
  • Front Pharmacol.2021, 12:744624.
  • Ecol Evol.2022, 12(11):e9459.
  • Antioxidants.2022, 11(3):592.
  • J Food Biochem.2021, 45(7):e13774.
  • Viruses.2021, 13(11):2118.
  • J Sep Sci.2020, 43(22):4148-4161.
  • Braz J Med Biol Res.2021, 54(12):e11183.
  • J Chem Inf Model.2021, 61(11):5708-5718.
  • Environ Toxicol Pharmacol.2019, 66:109-115
  • Oxid Med Cell Longev.2021, 2021:4883398.
  • Molecules.2020, 25(9):2111.
  • Int J Mol Sci.2020, 21(8):2790.
  • Agronomy 2021, 11(3),502.
  • Applied Biological Chemistry2022, 65(12)
  • Molecules.2022, 27(2):451.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Chem Pharm Bull (Tokyo).2017, 65(9):826-832
  • J Mater Chem B.2019, 7(39):5896-5919
  • Internoational J of Toxicology2020, 10.1177.
  • ...
  • 生物活性
    Description: Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MAPK activation, cAMP, MAP kinase and ROS generation through NADPH oxidase and mitochondria. It induces the differentiation in C6 cells, may through a PI 3-K-dependent pathway.
    Targets: JNK | p38MAPK | cAMP | PKC | Caspase | PARP | Calcium Channel | ROS | NADPH-oxidase | p21 | ERK | PI3K
    In vitro:
    Molecules. 2011 Jun 29;16(7):5561-73.
    Induction of apoptosis in human promyelocytic leukemia HL60 cells by panaxynol and panaxydol.[Pubmed: 21716177]
    Panaxynol and panaxydol are naturally occurring polyacetylenes, isolated from the lipophilic fractions of Panax notoginseng, that exert anti-proliferative effects against malignant cells. However, to the best of our knowledge, no study concerning the inhibitory effects of the two polyacetylenes on cell growth of human promyelocytic leukemia cells has been reported. In this paper, we examined the antiproliferation and proapoptotic effects of panaxynol and panaxydol on HL60 cells and investigated their mechanism of action.
    METHODS AND RESULTS:
    Cell growth inhibition of panaxynol and panaxydol were determined by trypan blue dye exclusion assays. Apoptosis of cells was revealed by morphological observation, analysis for nuclear DNA distribution and by annexin V-FITC/ PI staining using flow cytometry. It was found that panaxynol and panaxydol markedly inhibited proliferation of HL60 cells in a time- and dose-dependent manner via an apoptotic pathway. In concern with these findings, Western blot analysis showed proteolytic activation of PKCδ, caspase-3 activation and cleavage of poly (ADP [adenosine diphosphate]-ribose) polymerase in HL60 cells treated by panaxynol and panaxydol.
    CONCLUSIONS:
    In conclusion, panaxynol and panaxydol have profound effects on growth and apoptosis of HL60 cells, suggesting those substances are worthy of further exploration as potential anti-cancer agents.
    Yakugaku Zasshi. 2011;131(6):993-1000.
    Induction of differentiation by panaxydol in human hepatocarcinoma SMMC-7721 cells via cAMP and MAP kinase dependent mechanism.[Pubmed: 21628989]
    Panaxydol (PND) is one of the main non-peptidyl small molecules isolated from the lipophilic fractions of Panax notoginseng.
    METHODS AND RESULTS:
    The present study was carried out to demonstrate the potential effects of Panaxydol on the induction of differentiation of human liver carcinoma cell lines SMMC-7721. Cell viability was evaluated by MTT method and Trypan blue exclusion assay respectively. The changes of morphology were detected by transmission electron microscope. Inhibitors were applied to detect the signaling pathway of differentiation. The level of intracellular cyclic AMP was determined by radioimmunoassay. The expression of p-ERK, Id1, and p21 were determined by Western blot. We found that Panaxydol inhibit the proliferation of SMMC-7721 cells and caused the morphology and ultrastructure changes of SMMC-7721. Moreover, Panaxydol dose-dependently increased the secretion of albumin and alkaline phosphatase activity, and decreased the secretion of AFP correspondingly. These changes of differentiation markers in SMMC-7721 can be reversed by the protein kinase A inhibitor RpcAMPS and by MAP kinase kinase 1/2 inhibitor U0126 or sorafenib. Intracellular cAMP was elevated by Panaxydol in SMMC-7721 cells.
    CONCLUSIONS:
    Panaxydol dose-dependently decreased the expression of regulatory factors Id1 and increased the protein levels of p21 and p-ERK1/2 correspondingly. It suggested Panaxydol might be of value for further exploration as a potential anti-cancer agent via cAMP and MAP kinase-dependent mechanism.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.8402 mL 19.2012 mL 38.4025 mL 76.8049 mL 96.0061 mL
    5 mM 0.768 mL 3.8402 mL 7.6805 mL 15.361 mL 19.2012 mL
    10 mM 0.384 mL 1.9201 mL 3.8402 mL 7.6805 mL 9.6006 mL
    50 mM 0.0768 mL 0.384 mL 0.768 mL 1.5361 mL 1.9201 mL
    100 mM 0.0384 mL 0.192 mL 0.384 mL 0.768 mL 0.9601 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    人参炔K; Ginsenoyne K CFN96044 141947-42-4 C17H24O3 = 276.4 5mg QQ客服:2159513211
    党参炔醇; Lobetyol CFN92356 136171-87-4 C14H18O3 = 234.3 5mg QQ客服:1457312923
    党参炔苷; Lobetyolin CFN99104 136085-37-5 C20H28O8 = 396.43 20mg QQ客服:1413575084
    Lobetyolinin; Lobetyolinin CFN92357 142451-48-7 C26H38O13 = 558.6 10mg QQ客服:2056216494
    (3E,5E,11E)-tridecatriene-7,9-diyne-1,2-diacetate; (3E,5E,11E)-tridecatriene-7,9-diyne-1,2-diacetate CFN95191 N/A C17H18O4 = 286.3 5mg QQ客服:215959384
    11-羟基茉莉酸; 11-Hydroxyjasmonic acid CFN99457 140447-14-9 C12H18O4 = 226.3 5mg QQ客服:3257982914
    12-羟基茉莉酸; 12-Hydroxyjasmonic acid CFN99460 140631-27-2 C12H18O4 = 226.3 5mg QQ客服:215959384
    (S,E)-癸-2,9-二烯-4,6-二炔-1,8-二醇; (S,E)-Deca-2,9-diene-4,6-diyne-1,8-diol CFN97501 931114-98-6 C10H10O2 = 162.2 5mg QQ客服:1457312923
    (R,E)-癸-2-烯-4,6-二炔-1,8-二醇; (R,E)-Deca-2-ene-4,6-diyne-1,8-diol CFN97502 931116-24-4 C10H12O2 = 164.2 5mg QQ客服:3257982914
    人参环氧炔醇; Panaxydol CFN92797 72800-72-7 C17H24O2 = 260.4 20mg QQ客服:3257982914

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