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  • 丹皮酚

    Paeonol

    丹皮酚
    产品编号 CFN98926
    CAS编号 552-41-0
    分子式 = 分子量 C9H10O3 = 166.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The roots of Paeonia moutan Sim.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
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    丹皮酚 CFN98926 552-41-0 10mg QQ客服:1413575084
    丹皮酚 CFN98926 552-41-0 20mg QQ客服:1413575084
    丹皮酚 CFN98926 552-41-0 50mg QQ客服:1413575084
    丹皮酚 CFN98926 552-41-0 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universiti Sains Malaysia (Malaysia)
  • University of Hertfordshire (United Kingdom)
  • University of Wollongong (Australia)
  • University of Liège (Belgium)
  • University of Otago (New Zealand)
  • John Innes Centre (United Kingdom)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Almansora University (Egypt)
  • Max Rubner-Institut (MRI) (Germany)
  • VIT University (India)
  • University of Bordeaux (France)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Agricultural Research Organization (ARO) (Israel)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • PLoS One.2017, 12(3):e0173585
  • Life Sci.2022, 298:120488.
  • Molecules.2015, 20(10):19172-88
  • Mol Med Rep.2015, 12(5):7789-95
  • Cell Rep.2022, 39(1):110643.
  • Korean J. Food Preserv. 2021, 28(6):846-856.
  • J Phys Chem Lett.2021, 12(7):1793-1802.
  • Appl. Sci.2020, 10(16),5482.
  • PLoS One.2017, 12(8):e0181191
  • Journal of Chromatography A2020, 460942
  • Plant Physiol Biochem.2023, 202:107913.
  • Research Square2023, 2883170.
  • Phytochem Anal.2022, doi: 10.1002
  • Nutrients.2018, 10(12):E1998
  • Microb Biotechnol.2021, 14(5):2009-2024.
  • Pharmacogn J.2022, 14(2):350-357
  • Sci Rep. 2017, 17332(7)
  • Sci Rep.2023, 13(1):13610.
  • Molecules.2015, 20(11):20014-30
  • Int Immunopharmacol.2019, 71:361-371
  • Evid Based Complement Alternat Med.2018, 2018:1073509
  • Antioxidants (Basel).2020, 9(6):526.
  • Analytical Methods2018, 10(27)
  • ...
  • 生物活性
    Description: Paeonol has anticancer, anti-inflammatory, antioxidant and cardiovascular protective activities, it shows a novel inhibitory role on neuroinflammation, and presents a new candidate agent for the development of therapies for inflammation-related neurodegenerative diseases. Paeonol suppresses lipopolysaccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock. Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively; it inhibits PGE₂ synthesis and COX-2 expression, and modulates Sirtuin 1, PKCδ and c-Src signaling pathway.
    Targets: NO | NOS | AMPK | TNF-α | PKC | PGE | COX | ROS | GSK-3 | p53 | IL Receptor | p38MAPK | JNK | ERK | IkB | Caspase | Bcl-2/Bax | p65 | NF-kB | IKK | MAO-A | MAO-B | Src
    In vitro:
    J Ethnopharmacol. 2014 Jun 11;154(2):428-36.
    Paeonol protects against premature senescence in endothelial cells by modulating Sirtuin 1 pathway.[Pubmed: 24768807]
    Paeonol is a phenolic compound isolated mainly from Moutan cortex, root bark of Chinese Peony tree. Moutan cortex holds a significant value in traditional Chinese medicine for alleviating various oxidative stress-related diseases mainly atherosclerosis and myocardial infarction. The present study seeks to identify the protective mechanisms of paeonol in oxidative stress-induced premature senescence in endothelial cells.
    METHODS AND RESULTS:
    HUVECs were pretreated with paeonol or DMSO control at different doses for 24h prior to an exposure of 200μM of reactive oxygen species (ROS) inducer, hydrogen peroxide (H2O2). The protective effects of paeonol against H2O2-induced senescence were evaluated and the activation of Sirtuin 1 pathway by paeonol pretreatment was investigated in HUVECs. Paeonol attenuated H2O2-induced cell growth arrest at G0/G1 phase, reduced the percentage of SA-β-Gal positive cells and increased BrdU incorporation. In addition, enzymatic Sirt1 activation assay indicated that paeonol significantly increased lysyl deactylase activity of Sirt1 enzyme with a fold change of 2.4±0.195 (p<0.05). Furthermore, pretreatment with paeonol significantly decreased the levels of p53, acetyl H3K14 and H4K16 protein expression upregulated by H2O2 stimulation. The changes in the histone protein levels were accompanied with an increase in Sirt1 protein expression level.
    CONCLUSIONS:
    These findings suggest that paeonol protects endothelial cells against oxidative stress-induced premature senescence by modulating the expressions of Sirt1 protein and its substrates.
    Int J Mol Sci. 2014 Jul 2;15(7):11760-72.
    Paeonol suppresses chondrosarcoma metastasis through up-regulation of miR-141 by modulating PKCδ and c-Src signaling pathway.[Pubmed: 24992595]
    Chondrosarcoma, a primary malignant bone cancer, has potential for local invasion and distant metastasis, especially to the lungs. Patients diagnosed with it show poor prognosis. Paeonol (2'-hydroxy-4'-methoxyacetophenone), the main active compound of traditional Chinese remedy Paeonia lactiflora Pallas, exhibits anti-inflammatory and anti-tumor activity; whether paeonol regulates metastatic chondrosarcoma is largely unknown.
    METHODS AND RESULTS:
    Here, we find paeonol do not increase apoptosis. By contrast, at non-cytotoxic concentrations, paeonol suppresses migration and invasion of chondrosarcoma cells. We also demonstrate paeonol enhancing miR-141 expression and miR-141 inhibitor reversing paeonol-inhibited cell motility; paeonol also reduces protein kinase C (PKC)d and c-Src kinase activity.
    CONCLUSIONS:
    Since paeonol inhibits migration and invasion of human chondrosarcoma via up-regulation of miR-141 via PKCd and c-Src pathways, it thus might be a novel anti-metastasis agent for treatment of metastatic chondrosarcoma.
    Int Immunopharmacol. 2007 Mar;7(3):343-50.
    Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-kappaB signaling pathways.[Pubmed: 17276892 ]
    Paeonol (2'-hydroxy-4'-methoxyacetophenone), the main active compound of the traditionally used Chinese herb Paeonia lactiflora Pallas, has anti-inflammatory, antioxidant and cardiovascular protective activities.
    METHODS AND RESULTS:
    We studied how the levels of intercellular adhesion molecule-1 (ICAM-1), one of the key molecules in the development of atherosclerosis, might be affected by paeonol in tumor necrosis factor-alpha (TNF-alpha)-activated human umbilical vein endothelial cells (HUVECs). Paeonol concentration-dependently inhibited the production of ICAM-1; it inhibited nuclear factor-kappaB (NF-kappaB) p65 translocation into the nucleus and the phosphorylation of inhibitory factor kappaBalpha (IkappaBalpha). It also blocked the TNF-alpha-induced phosphorylation of p38 and extracellular signal-regulated kinase (ERK), which are involved in regulating ICAM-1 production by TNF-alpha. Paeonol inhibited U937 monocyte adhesion to HUVECs stimulated by TNF-alpha, suggesting that it may inhibit the binding of monocytes to endothelium by regulating the production of critical adhesion molecules by TNF-alpha. The inhibitory effect of paeonol on ICAM-1 production might be mediated by inhibiting p38, ERK and NF-kappaB signaling pathways, which are involved in TNF-alpha-induced ICAM-1 production.
    CONCLUSIONS:
    Thus, paeonol may be beneficial in the treatment of cardiovascular disorders such as atherosclerosis.
    In vivo:
    Int J Mol Sci. 2015 Apr 21;16(4):8844-60.
    Effects of paeonol on anti-neuroinflammatory responses in microglial cells.[Pubmed: 25906473]
    Increasing studies suggest that inflammatory processes in the central nervous system mediated by microglial activation plays an important role in numerous neurodegenerative diseases. Development of planning for microglial suppression is considered a key strategy in the search for neuroprotection. Paeonol is a major phenolic component of Moutan Cortex, widely used as a nutrient supplement in Chinese medicine. In this study, we investigated the effects of paeonol on microglial cells stimulated by inflammagens.
    METHODS AND RESULTS:
    Paeonol significantly inhibited the release of nitric oxide (NO) and the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Treatment with paeonol also reduced reactive oxygen species (ROS) production and inhibited an ATP-induced increased cell migratory activity. Furthermore, the inhibitory effects of neuroinflammation by paeonol were found to be regulated by phosphorylated adenosine monophosphate-activated protein kinase-α (AMPK-α) and glycogen synthase kinase 3 α/β (GSK 3α/β). Treatment with AMPK or GSK3 inhibitors reverse the inhibitory effect of neuroinflammation by paeonol in microglial cells. Furthermore, paeonol treatment also showed significant improvement in the rotarod performance and microglial activation in the mouse model as well.
    CONCLUSIONS:
    The present study is the first to report a novel inhibitory role of paeonol on neuroinflammation, and presents a new candidate agent for the development of therapies for inflammation-related neurodegenerative diseases.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.0168 mL 30.0842 mL 60.1685 mL 120.3369 mL 150.4212 mL
    5 mM 1.2034 mL 6.0168 mL 12.0337 mL 24.0674 mL 30.0842 mL
    10 mM 0.6017 mL 3.0084 mL 6.0168 mL 12.0337 mL 15.0421 mL
    50 mM 0.1203 mL 0.6017 mL 1.2034 mL 2.4067 mL 3.0084 mL
    100 mM 0.0602 mL 0.3008 mL 0.6017 mL 1.2034 mL 1.5042 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    榼藤子苷; Phaseoloidin CFN91665 118555-82-1 C14H18O9 = 330.29 5mg QQ客服:2056216494
    2,4-二羟基苯乙酸乙酯; Ethyl 2,4-dihydroxyphenylacetate CFN97158 67828-62-0 C10H12O4 = 196.2 5mg QQ客服:3257982914
    尿黑酸,高龙胆酸; Homogentisic acid CFN93816 451-13-8 C8H8O4 = 168.2 20mg QQ客服:215959384
    6-羟基苯并呋喃-2(3H)-酮; 6-Hydroxybenzofuran-2(3H)-one CFN98320 2688-49-5 C8H6O3 = 150.1 5mg QQ客服:1457312923
    苯甲酸; Benzoic acid CFN97121 65-85-0 C7H6O2 = 122.1 20mg QQ客服:215959384
    3-甲基邻苯二酚; 3-Methylcatechol CFN96014 488-17-5 C7H8O2 = 124.1 20mg QQ客服:3257982914
    3,5-二羟基甲苯; Orcinol CFN98796 504-15-4 C7H8O2 = 124.1 20mg QQ客服:1413575084
    苔黑酚葡萄糖苷; Sakakin CFN98059 21082-33-7 C13H18O7 = 286.3 20mg QQ客服:2056216494
    苔黑酚龙胆二糖苷; Orcinol gentiobioside CFN90679 164991-86-0 C19H28O12 = 448.42 20mg QQ客服:2159513211
    Orcinol 1-O-beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside; Orcinol 1-O-beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside CFN95109 868557-54-4 C18H26O11 = 418.4 5mg QQ客服:2056216494

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