2-吲哚酮

Oxindole

	产品编号	CFN96151
	CAS编号	59-48-3
	分子式 = 分子量	C₈H₇NO = 133.2
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The herbs of Isatis indigotica
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
2-吲哚酮	CFN96151	59-48-3	10mg	QQ客服：3257982914
2-吲哚酮	CFN96151	59-48-3	20mg	QQ客服：3257982914
2-吲哚酮	CFN96151	59-48-3	50mg	QQ客服：3257982914
2-吲哚酮	CFN96151	59-48-3	100mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Aarhus University (Denmark)

The Institute of Cancer Research (United Kingdom)

Korea Food Research Institute(KFRI) (Korea)

Shanghai University of TCM (China)

Utah State University (USA)

Wageningen University (Netherlands)

University of Bordeaux (France)

University of Maryland School of Medicine (USA)

Sri Ramachandra University (India)

University of Perugia (Italy)

Kamphaengphet Rajabhat University (Thailand)

Georgia Institute of Technology (USA)

Chulalongkorn University (Thailand)

Shanghai Institute of Organic Chemistry (China)

More...

Description:

Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.

In vitro:

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3285-9.

Synthesis of novel derivatives of oxindole, their urease inhibition and molecular docking studies.[Pubmed: 26077497]

We synthesized a series of novel 5-24 derivatives of oxindole.
METHODS AND RESULTS:
The synthesis started from 5-chlorooxindole, which was condensed with methyl 4-carboxybezoate and result in the formation of benzolyester derivatives of oxindole which was then treated with hydrazine hydrate. The oxindole benzoylhydrazide was treated with aryl acetophenones and aldehydes to get target compounds 5-24. The synthesized compounds were evaluated for urease inhibition; the compound 5 (IC50 = 13.00 ± 0.35 μM) and 11 (IC50 = 19.20 ± 0.50 μM) showed potent activity as compared to the standard drug thiourea (IC50 = 21.00 ± 0.01 μM). Other compounds showed moderate to weak activity.
CONCLUSIONS:
All synthetic compounds were characterized by different spectroscopic techniques including (1)H NMR, (13)C NMR, IR and EI MS.The molecular interactions of the active compounds within the binding site of urease enzyme were studied through molecular docking simulations.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
2',3'-epoxy-N-methylatanine; 2',3'-epoxy-N-methylatanine	CFN95751	1384841-46-6	C₁₆H₁₉NO₃ = 273.3	10mg	QQ客服：3257982914
Glycosolone; Glycosolone	CFN96256	67879-81-6	C₁₆H₁₉NO₃ = 273.3	5mg	QQ客服：1413575084
花椒朋碱; Zanthobungeanine	CFN96395	64190-94-9	C₁₆H₁₇NO₃ = 271.3	20mg	QQ客服：3257982914
8-甲氧基弗林德碱; 8-Methoxyflindersine	CFN91530	35989-00-5	C₁₅H₁₅NO₃ = 257.3	5mg	QQ客服：1413575084
前茵芋碱; Preskimmianine	CFN96377	38695-41-9	C₁₇H₂₁NO₄ = 303.4	5mg	QQ客服：1457312923
3,4-二氢-6,7-(亚甲基双氧)-2(1H)-喹啉酮; 3,4-Dihydro-6,7-(methylenedioxy)-2(1H)-quinolinone	CFN92396	94527-34-1	C₁₀H₉NO₃ = 191.2	5mg	QQ客服：215959384
2-吲哚酮; Oxindole	CFN96151	59-48-3	C₈H₇NO = 133.2	20mg	QQ客服：1413575084
2-(4-Hydroxy-2-oxoindolin-3-yl)acetonitrile; 2-(4-Hydroxy-2-oxoindolin-3-yl)acetonitrile	CFN96144	1380540-77-1	C₁₀H₈N₂O₂ = 188.2	5mg	QQ客服：2159513211
(3R,4R)-3,4-二氢-3-羟基-4-甲基苯并[G]喹啉-2,5,10(1H)-三酮; Griffithazanone A	CFN97943	240122-30-9	C₁₄H₁₁NO₄ = 257.2	5mg	QQ客服：215959384
Oxohydrastinine; Oxohydrastinine	CFN92334	552-29-4	C₁₁H₁₁NO₃ = 205.2	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	7.5075 mL	37.5375 mL	75.0751 mL	150.1502 mL	187.6877 mL
5 mM	1.5015 mL	7.5075 mL	15.015 mL	30.03 mL	37.5375 mL
10 mM	0.7508 mL	3.7538 mL	7.5075 mL	15.015 mL	18.7688 mL
50 mM	0.1502 mL	0.7508 mL	1.5015 mL	3.003 mL	3.7538 mL
100 mM	0.0751 mL	0.3754 mL	0.7508 mL	1.5015 mL	1.8769 mL