奥沙京

Osajin

	产品编号	CFN97917
	CAS编号	482-53-1
	分子式 = 分子量	C₂₅H₂₄O₅ = 404.5
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Flavonoids
	植物来源	The herbs of Derris robusta
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
奥沙京	CFN97917	482-53-1	1mg	QQ客服：1457312923
奥沙京	CFN97917	482-53-1	5mg	QQ客服：1457312923
奥沙京	CFN97917	482-53-1	10mg	QQ客服：1457312923
奥沙京	CFN97917	482-53-1	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universidad Miguel Hernández (Spain)

Universitas islam negeri Jakarta (Indonesia)

Uniwersytet Gdański (Poland)

Medical University of Gdansk (Poland)

VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)

Warszawski Uniwersytet Medyczny (Poland)

Centralised Purchases Unit (CPU), B.I.T.S (India)

University of Zurich (Switzerland)

Macau University of Science and Technology (China)

University of Limpopo (South Africa)

University of Parma (Italy)

Technical University of Denmark (Denmark)

Osmania University (India)

The University of Newcastle (Australia)

More...

Description:

Osajin shows antitumor activity in different tumor cell lines, it induces apoptosis in human NPC cells through multiple apoptotic pathways, including the extrinsic death receptor pathway, and intrinsic pathways relying on mitochondria and endoplasmic reticulum stress. The cardioprotection provided by Osajin treatment results from the suppression of oxidative stress and correlates with the improved ventricular function.

Targets:

P450 (e.g. CYP17) | Bcl-2/Bax | Caspase

In vivo:

Nat Prod Commun. 2014 Dec;9(12):1723-4.

Effect of osajin and pomiferin on antidiabetic effects from normal and streptozotocin-induced diabetic rats.[Pubmed: 25632468]

The present study evaluated the antidiabetic effect of osajin and pomiferin from the osajin orange in normal and streptozotocin-induced diabetic rats.
METHODS AND RESULTS:
Pomiferin in the streptozotocin-induced diabetic effects showed significant hypoglycemic activity for 14 days significantly decreased the serum glucose, triglyceride while it increased the serum insulin in diabetic rats but not in normal rats (p < 0.05; at doses of 100 and 300 mg/kg for 14 days). Pomiferin showed potential in anti-diabetic effects compared to osajin. It also has no effects on C-peptide (ECLIA). Further structure-activity relationships of aromatic position 3 on ring B from osajin and pomiferin will be reported in due course.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):93-100.

Effects of prenylated isoflavones osajin and pomiferin in premedication on heart ischemia-reperfusion.[Pubmed: 16936909]

METHODS AND RESULTS:
The present 15 days study was undertaken to evaluate the cardioprotective potential of the prenylated isoflavones Osajin and pomiferin isolated from the infructences of Maclura pomifera, Moraceae, against ischemia-reperfusion induced injury in rat hearts as a model of antioxidant-based composite therapy. The first treatment group received Osajin (5 mg/kg/day in 0.5% Avicel); the second treatment group received pomiferin (5 mg/kg/day in 0.5% Avicel); the placebo group received only 0.5 Avicel; the last was an untreated control group. Biochemical indicator of oxidative damage-lipid peroxidation product malondialdehyde, antioxidant enzymes - superoxide dismutase, glutathione peroxidase, total antioxidant activity in serum and myocardium were evaluated. The effect of Osajin and pomiferin on cardiac function, left ventricular end-diastolic pressure, left ventricular pressure and peak positive +dP/dt ischemia and reperfusion, also was examined.
CONCLUSIONS:
The results demonstrate that Osajin and pomiferin attenuates the myocardial dysfunction provoked by ischemiareperfusion. This was confirmed by an increase in both antioxidant enzyme values and total antioxidant activity. The cardioprotection provided by Osajin and pomiferin treatment results from the suppression of oxidative stress and this correlates with improved ventricular function.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Millewanin G; Millewanin G	CFN96200	874303-33-0	C₂₅H₂₆O₇ = 438.5	5mg	QQ客服：215959384
Millewanin H; Millewanin H	CFN96205	874303-34-1	C₂₅H₂₆O₇ = 438.5	5mg	QQ客服：215959384
6,8-二异戊烯基香豌豆苷元; 6,8-Diprenylorobol	CFN97705	66777-70-6	C₂₅H₂₆O₆ = 422.48	5mg	QQ客服：1457312923
山豆根酮 B1; Euchrenone B1	CFN92668	119061-09-5	C₃₀H₃₄O₅ = 474.6	5mg	QQ客服：3257982914
3',5'-二异戊烯基金雀异黄素; 3',5'-Diprenylgenistein	CFN92665	104055-80-3	C₂₅H₂₆O₅ = 406.5	5mg	QQ客服：1457312923
鱼藤属异黄酮 B; Derrisisoflavone B	CFN96046	246870-75-7	C₂₅H₂₆O₆ = 422.5	5mg	QQ客服：215959384
5,7,4'-三羟基-6,3'-二异戊烯基异黄酮; Lupalbigenin	CFN97245	76754-24-0	C₂₅H₂₆O₅ = 406.5	5mg	QQ客服：1413575084
异鱼藤色烯异黄酮; Isochandalone	CFN97894	121747-90-8	C₂₅H₂₄O₅ = 404.5	5mg	QQ客服：1457312923
Isoerysenegalensein E; Isoerysenegalensein E	CFN96071	478158-77-9	C₂₅H₂₆O₆ = 422.5	5mg	QQ客服：2056216494
Erysenegalensein E; Erysenegalensein E	CFN96072	154992-17-3	C₂₅H₂₆O₆ = 422.48	5mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4722 mL	12.3609 mL	24.7219 mL	49.4438 mL	61.8047 mL
5 mM	0.4944 mL	2.4722 mL	4.9444 mL	9.8888 mL	12.3609 mL
10 mM	0.2472 mL	1.2361 mL	2.4722 mL	4.9444 mL	6.1805 mL
50 mM	0.0494 mL	0.2472 mL	0.4944 mL	0.9889 mL	1.2361 mL
100 mM	0.0247 mL	0.1236 mL	0.2472 mL	0.4944 mL	0.618 mL

奥沙京

Osajin

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