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  • 盐酸降槟榔碱

    Norarecoline Hydrochloride

    盐酸降槟榔碱
    产品编号 CFN93318
    CAS编号 6197-39-3
    分子式 = 分子量 C7H12ClNO2 = 177.62
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The fruits of Areca catechu
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    盐酸降槟榔碱 CFN93318 6197-39-3 1mg QQ客服:1413575084
    盐酸降槟榔碱 CFN93318 6197-39-3 5mg QQ客服:1413575084
    盐酸降槟榔碱 CFN93318 6197-39-3 10mg QQ客服:1413575084
    盐酸降槟榔碱 CFN93318 6197-39-3 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Julius Kühn-Institut (Germany)
  • Michigan State University (USA)
  • Charles Sturt University (Denmark)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • University of Fribourg (Switzerland)
  • University of Wuerzburg (Germany)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Chem.2019, 279:80-87
  • Vietnam Journal of Science2022, 64(2), 69-75.
  • Sci Rep. 2018, 10590
  • J Insect Sci.2020, 20(5):18.
  • Molecules2022, 27(11):3606.
  • Oxid Med Cell Longev.2020, 2020:8887251.
  • Korean Herb. Med. Inf. 2016, 4(1):35-42
  • Int J Mol Sci.2021, 22(11):5503.
  • Antioxidants (Basel).2021, 10(9):1487.
  • Chemistry of Plant Materials.2019, 215-222
  • Antioxidants.2022, 11(3):491.
  • Molecules.2020, 25(9):2081.
  • Iranian Journal of Pharmaceutical Sciences2021, 17(2):25-36
  • Korean J. Medicinal Crop Sci.2022, 30(2):117-123.
  • Pharm Biomed Res2023, 9(3):173-182.
  • Molecules.2023, 28(7):3039.
  • Korean Journal of Plant Resources2021, 34(1):52-58.
  • Acta Chromatographica2021, 00960.
  • Research SPJ.2024, 0377.
  • J. Pharm. Biomed. Anal.2024, 245:116193.
  • Molecules.2019, 24(12):E2286
  • J Mol Med (Berl).2018, 96(7):661-672
  • J Food Sci.2022, 87(11):4905-4916.
  • ...
  • 生物活性
    Description: Norarecoline is a muscarinic agonist.
    In vitro:
    Arzneimittelforschung. 1989 May;39(5):539-44.
    Synthesis and muscarinic activity of a series of tertiary and quaternary N-substituted guvacine esters structurally related to arecoline and arecaidine propargyl ester.[Pubmed: 2757669]
    A series of tertiary and quaternary N-substituted guvacine (1,2,5,6-tetrahydro-3-carboxy-pyridine) methyl and propargyl esters have been synthesized and tested for muscarinic/antimuscarinic activity on rat ileum and electrically paced left atria.
    METHODS AND RESULTS:
    Arecoline and arecaidine propargyl ester (APE) as well as their corresponding N-demethyl derivatives, guvacoline (norarecoline, Norarecoline Hydrochloride) and guvacine propargyl ester, acted as full agonists at both atrial and ileal muscarinic receptors (range of pD2-values 6.09-8.07). However, in both preparations arecoline and APE were clearly more potent (up to 15-fold) than their N-demethyl analogues. Replacement of the N-methyl group in arecoline and APE by larger substituents (ethyl, n-propyl, n-butyl, benzyl, phenylethyl) as well as N-methylation resulted in a decrease or even a complete loss of agonistic activity. In both organs, the propargyl esters usually showed higher potency than the corresponding methyl ester analogues.
    CONCLUSIONS:
    N-Ethylguvacine propargyl ester and APE methiodide displayed pronounced agonistic activity in the atria (pD2 approximately 6.5; intrinsic activity = 0.79 and 0.67, respectively) but behaved as competitive antagonists in the ileum (pA2 = 6.06 and 5.62, respectively). Beside the lower sensitivity to muscarinic agonists of the rat ileum as compared to rat atria, the cardioselective stimulant action of both agents may also be due to their ability to recognize structural differences between atrial M2 alpha and ileal M2 beta muscarinic receptor subtypes.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.63 mL 28.15 mL 56.3 mL 112.5999 mL 140.7499 mL
    5 mM 1.126 mL 5.63 mL 11.26 mL 22.52 mL 28.15 mL
    10 mM 0.563 mL 2.815 mL 5.63 mL 11.26 mL 14.075 mL
    50 mM 0.1126 mL 0.563 mL 1.126 mL 2.252 mL 2.815 mL
    100 mM 0.0563 mL 0.2815 mL 0.563 mL 1.126 mL 1.4075 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    马钱苷元; Loganetin CFN98369 29748-10-5 C11H16O5 = 228.2 5mg QQ客服:1413575084
    坡模醇酸, 坡模酸; Pomolic acid CFN99433 13849-91-7 C30H48O4 = 472.7 10mg QQ客服:3257982914
    蓬莱葛胺; Gardneramine CFN98447 34274-91-4 C23H28N2O5 = 412.5 5mg QQ客服:2159513211
    新夏佛托苷; Neoschaftoside CFN92071 61328-41-4 C26H28O14 = 564.5 10mg QQ客服:2056216494

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