闹达柯裂亭

Nodakenetin

	产品编号	CFN98788
	CAS编号	495-32-9
	分子式 = 分子量	C₁₄H₁₄O₄ = 246.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Coumarins
	植物来源	The herbs of Peucedanum decursivum Maxim.
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产品名称	产品编号	CAS编号	包装	QQ客服
闹达柯裂亭	CFN98788	495-32-9	10mg	QQ客服：2159513211
闹达柯裂亭	CFN98788	495-32-9	20mg	QQ客服：2159513211
闹达柯裂亭	CFN98788	495-32-9	50mg	QQ客服：2159513211
闹达柯裂亭	CFN98788	495-32-9	100mg	QQ客服：2159513211

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Description:

Nodakenetin has antioxidant activity, it displays the least irritant and least persistent reactions on mouse ears, and exhibits the least cytotoxic capacity against brine shrimp larvae. Nodakenetin angelate is used as an antiarthritic and nerve tonic.

Targets:

In vitro:

Arch Pharm Res. 2012 Jan;35(1):179-92.

In vitro antioxidant and anti-inflammatory activities of Angelica decursiva.[Pubmed: 22297757 ]

Mounting evidences continue to support the involvement of oxidative/nitrosative stress and inflammation in the pathogenesis of many diseases. Plant constituents having antioxidant activities together with anti-inflammatory activities may provide better opportunities to develop anti-inflammatory agents.
METHODS AND RESULTS:
In view of this, we evaluated the antioxidant and antiinflammatory activities of methanolic extract of whole plants of Angelica decursiva, and its solvent soluble fractions via in vitro activities against lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 cells, as well as in vitro scavenging activities against 1,1-diphenyl-2-picrylhydrazyl, 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid, NO, and peroxynitrite. Among the tested fractions, the ethyl acetate fraction was found as the most active antioxidant fraction together with significant anti-inflammatory effect. From the active ethyl acetate fraction, four coumarin derivatives consisting of nodakenin, Nodakenetin, umbelliferone, and umbelliferone-6-carboxylic acid, along with a phenolic compound, vanillic acid, were isolated. Among them, umbelliferone 6-carboxylic acid and vanillic acid were isolated for the first time from this plant. In all antioxidant assays, vanillic acid showed the highest antioxidant potential followed by umbelliferone 6-carboxylic acid among the isolated compounds. In the anti-inflammatory assay, umbelliferone 6-carboxylic acid exhibited the highest inhibitory activity against lipopolysaccharide-induced NO production in RAW 264.7 cells with an IC(50) value of 72.98 μg/mL.
CONCLUSIONS:
Therefore, the present study reveals the potential antioxidant and antiinflammatory activities of whole plants of A. decursiva and its constituents, mainly umbelliferone 6-carboxylic acid, which could be used in the development of therapeutic and preventive agents for oxidative stress-related inflammatory diseases.

In vivo:

J Asian Nat Prod Res. 2008 Jan-Feb;10(1-2):49-58.

Irritant and cytotoxic coumarins from Angelica glauca Edgew roots.[Pubmed: 18058380 ]

Irritant and cytotoxic potentiality of six coumarins, isolated for the first time from the roots of Angelica glauca identified as 5,6,7-trimethoxycoumarin, 6-methoxy-7,8-methylenedioxycoumarin, bergapten, decursinol angelate, decursin, and Nodakenetin, were investigated.
METHODS AND RESULTS:
The irritant potential was explored by open mouse ear assay, evaluating their ID(50) after acute and by IU (Irritant units) after chronic effects, while the cytotoxic capability was explored by their LC(50), using brine shrimp (Artemia salina) larvae (nauplii). All the coumarins exhibited well-defined irritancy on mouse's ears, compared with the positive controlled euphorbium reaction and cytotoxic response against brine shrimp larvae, compared with the positive control colchicine. Decursinol angelate and decursin were the most potent and persistent irritant compounds with least ID(50), whose reactions lasted for 48 h. 6-Methoxy-7,8-methylenedioxycoumarin and bergaten revealed an intermediate irritant reactions, while 5,6,7-trimethoxycoumarin and Nodakenetin displayed the least irritant and least persistent reactions on mouse ears. Both decursin and decursinol angelate also appeared to be the stronger cytotoxic agents than other coumarins.
CONCLUSIONS:
5,6,7-trimethoxycoumarin displayed an intermediate cytotoxic behaviour, while other three coumarins, i.e., 6-methoxy-7,8-methylenedioxycoumarin, bergapten, and Nodakenetin, exhibited the least cytotoxic capacity against brine shrimp larvae.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
芸香霉素，芸香亭; Rutaretin	CFN97825	13895-92-6	C₁₄H₁₄O₅ = 262.26	5mg	QQ客服：3257982914
前胡香豆精 G; Qianhucoumarin G	CFN92800	68692-61-5	C₁₄H₁₄O₅ = 262.3	5mg	QQ客服：2056216494
闹达柯裂亭; Nodakenetin	CFN98788	495-32-9	C₁₄H₁₄O₄ = 246.3	20mg	QQ客服：2056216494
异紫花前胡内酯异戊烯酸酯; Isopropylidenylacetyl-marmesin	CFN90887	35178-20-2	C₁₉H₂₀O₅ = 328.4	20mg	QQ客服：2056216494
异紫花前胡素当归酯; Marmesin angelate	CFN80120	13209-79-5	C₁₉H₂₀O₅ = 328.36	5mg	QQ客服：2159513211
Ammijin; Ammijin	CFN92711	495-30-7	C₂₀H₂₄O₉ = 408.4	5mg	QQ客服：215959384
紫花前胡苷; Nodakenin	CFN90232	495-31-8	C₂₀H₂₄O₉ = 408.40	20mg	QQ客服：2056216494
6'-O-(反式阿魏酰基)-紫花前胡苷; 6'-Feruloylnodakenin	CFN95202	131623-14-8	C₃₀H₃₂O₁₂ = 584.6	10mg	QQ客服：2159513211
紫花前胡苷I; Decuroside I	CFN95004	96638-79-8	C₂₆H₃₄O₁₄ = 570.6	5mg	QQ客服：215959384
1'-O-Beta-D-吡喃葡萄糖基-3-羟基闹达柯裂亭; Smyrindioloside	CFN97442	87592-77-6	C₂₀H₂₄O₁₀ = 424.4	10mg	QQ客服：1457312923

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.0601 mL	20.3004 mL	40.6009 mL	81.2018 mL	101.5022 mL
5 mM	0.812 mL	4.0601 mL	8.1202 mL	16.2404 mL	20.3004 mL
10 mM	0.406 mL	2.03 mL	4.0601 mL	8.1202 mL	10.1502 mL
50 mM	0.0812 mL	0.406 mL	0.812 mL	1.624 mL	2.03 mL
100 mM	0.0406 mL	0.203 mL	0.406 mL	0.812 mL	1.015 mL

闹达柯裂亭

Nodakenetin

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